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Toxicology. 2004 Apr 15;197(2):92-9. Links
[In Process Citation]
Isomura H, Fujie K, Shibata K, Inoue N, Iizuka T, Takebe G,
Takahashi K, Nishihira J, Izumi H, Sakamoto W.
Department of Biochemistry, School of Dentistry, Hokkaido
University, North 13 West 7 Kita-ku, Hokkaido, Sapporo
060, Japan.
Osteoporosis is associated with many etiological causes such
as nutrition, cytokines, hormones, and aging. Recently,
reactive oxygen species (ROS) are considered to be
responsible for the aging process and osteoporosis. We
investigated the relationship between ROS and bone
metabolism in young female and postmenopausal rats, by using
dietary iron overload and several indices including bone
metabolic markers, oxidative stress and antioxidant markers,
and cytokines. Postmenopausal rats exhibited significant
decreases in serum alkaline phosphatase activity and the
level of osteocalcin as bone formation markers compared with
young female rats; however, urinary excretion of
deoxypyridinoline, a bone resorption marker, did not change.
On the other hand, a 5% iron lactate diet for 4 weeks in
postmenopausal rats led to significantly increased excretion
of urinary deoxypyridinoline and 8-hydroxy-2'-deoxyguanosine
(8-OHdG) but not serum alkaline phosphatase activity.
Interestingly, the diet induced significant increases of
serum osteopontin and TGF-beta1, augumenting osteoclast-
mediated bone resorption through the RANK/RANKL pathway [J.
Clin. Invest. 112 (2003) 181]. TGF-beta1 showed a negative
correlation with serum glutathione peroxidase (GPx) activity
( [Formula: see text], [Formula: see text] ), but a positive
correlation with the serum iron level ( [Formula: see text],
[Formula: see text] ). Taken together, these results suggest
for the first time that oxidative stress could be involved
in the pathogenesis of metabolic bone diseases such as
osteoporosis as demonstrated by analysis of the relationship
between bone metabolism and oxidative stress.
PMID: 15003320 [PubMed - in process]
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[In Process Citation]
Isomura H, Fujie K, Shibata K, Inoue N, Iizuka T, Takebe G,
Takahashi K, Nishihira J, Izumi H, Sakamoto W.
Department of Biochemistry, School of Dentistry, Hokkaido
University, North 13 West 7 Kita-ku, Hokkaido, Sapporo
060, Japan.
Osteoporosis is associated with many etiological causes such
as nutrition, cytokines, hormones, and aging. Recently,
reactive oxygen species (ROS) are considered to be
responsible for the aging process and osteoporosis. We
investigated the relationship between ROS and bone
metabolism in young female and postmenopausal rats, by using
dietary iron overload and several indices including bone
metabolic markers, oxidative stress and antioxidant markers,
and cytokines. Postmenopausal rats exhibited significant
decreases in serum alkaline phosphatase activity and the
level of osteocalcin as bone formation markers compared with
young female rats; however, urinary excretion of
deoxypyridinoline, a bone resorption marker, did not change.
On the other hand, a 5% iron lactate diet for 4 weeks in
postmenopausal rats led to significantly increased excretion
of urinary deoxypyridinoline and 8-hydroxy-2'-deoxyguanosine
(8-OHdG) but not serum alkaline phosphatase activity.
Interestingly, the diet induced significant increases of
serum osteopontin and TGF-beta1, augumenting osteoclast-
mediated bone resorption through the RANK/RANKL pathway [J.
Clin. Invest. 112 (2003) 181]. TGF-beta1 showed a negative
correlation with serum glutathione peroxidase (GPx) activity
( [Formula: see text], [Formula: see text] ), but a positive
correlation with the serum iron level ( [Formula: see text],
[Formula: see text] ). Taken together, these results suggest
for the first time that oxidative stress could be involved
in the pathogenesis of metabolic bone diseases such as
osteoporosis as demonstrated by analysis of the relationship
between bone metabolism and oxidative stress.
PMID: 15003320 [PubMed - in process]
------------------------------------------------------------
--------------
------
Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking