I am now starting a hypertrophy phase of lifting. I have read many articles on t-nation.com and come across the approach of lifting more frequently, but with slightly less total stress in each workout.
I find that if I were to do say, 5x10 of 1 leg squats, my muscles would be trashed and completely useless for about 5 days.
But if I cut it down to around 2x10,(which is still enough to induce some soreness), I can recover from that much quicker. I would use this protocol 3 times a week.
Basically, is what i am getting at, is: I think there is a point where addition stress(more sets) will not result in a greater stimulus for growth. the goal would be to do the least amount of total work that results in a hypertrophy inducing stimulus. This way, you could eventually work up to working the muscle every day, and never having that crippling soreness, all the while achieving the most hypertrophy.
Chad Waterbury of t-nation.com wrote the article on this.
http://www.t-nation.com/readTopic.do?id=673054&pageNo=0
I am going to experiment with this method because I can not do the traditional method of lifting to fatigue, it leaves me incredibly sore for days.
The reason I want to specifically build more muscle is because I know in the long term, I need to if I want to reach my peak in sprinting. I'm just too skinny right now.