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"Sonos" <[email protected]> wrote in message news:<[email protected]>...
> On 8-Mar-2004, Jim Chinnis
> <[email protected]> wrote:
>
> > "Sonos" <[email protected]> wrote in part:
> >
> > >Here is the press release... (not that I agree with it,
> > >however)
> > >
> > >Aggressive Statin Therapy Boosts Heart-Attack Survival
> >
> > What (main) aspects do you disagree with?
> > --
> > Jim Chinnis Warrenton, Virginia, USA
>
> I read some of the later posts about the authorship of the
> study, and although informative, did not yet identify the
> funding source (or if it was listed, I missed it). It is
> important to know who has what at stake in this study. Not
> that funding source invalidates a study, but funding
> sources are strongly associated with motive (although not
> equivalent by any means). Getting to the true motive of
> any study requires conversation and deliberation, and in
> my experience will never fully be found in print.
>
> I worry about agressive statin therapy for many reasons,
> and not all of them can be found in the physician's desk
> reference. Long term agressive statin therapy, especially
> with the more potent versions that are in part distinct
> from the fungal derivatives introduce a whole new set of
> drug effects that are poorly understood. It is easier to
> say 'statin' than it is 'HMG-CoA reductase inhibitor'.
> Unfortunately the definitions are synonymous in medicine
> now, just like 'aspirin' and 'salicylic acid', but are
> incorrect.
>
> As another example, consider the question "When does a
> Dell Computer stop becoming a Dell?". If I purchase a Dell
> to run program HMG-CoA, and remove or add components, so
> that eventually, over time the only thing left from the
> original Dell is the outer case. Is it still a Dell? If
> not, when did it stop being a 'Dell'? Yet the computer
> runs the program HMG-CoA like it did when I first
> purchased it.
>
> So we see a similar trend in 'statins'. When does a statin
> stop being a stain?
>
> If you factor these gradual trends of changing the
> molecular structure for the gain of lowering
> cholesterol, it's a dead end road - going nowhere. Why?
> Because not one single study ever completed has proved
> that elevated cholesterol causes atherosclerosis. Yet
> here we are in 2004 with a firmly imbedded notion now so
> that it is almost instinctual, that cholesterol is no
> longer associated with atherosclerosis, but actually is
> the cause.
>
> A grave mistake.
Science...puuurrrrrrrrrrrrrrrrr b'adant
> On 8-Mar-2004, Jim Chinnis
> <[email protected]> wrote:
>
> > "Sonos" <[email protected]> wrote in part:
> >
> > >Here is the press release... (not that I agree with it,
> > >however)
> > >
> > >Aggressive Statin Therapy Boosts Heart-Attack Survival
> >
> > What (main) aspects do you disagree with?
> > --
> > Jim Chinnis Warrenton, Virginia, USA
>
> I read some of the later posts about the authorship of the
> study, and although informative, did not yet identify the
> funding source (or if it was listed, I missed it). It is
> important to know who has what at stake in this study. Not
> that funding source invalidates a study, but funding
> sources are strongly associated with motive (although not
> equivalent by any means). Getting to the true motive of
> any study requires conversation and deliberation, and in
> my experience will never fully be found in print.
>
> I worry about agressive statin therapy for many reasons,
> and not all of them can be found in the physician's desk
> reference. Long term agressive statin therapy, especially
> with the more potent versions that are in part distinct
> from the fungal derivatives introduce a whole new set of
> drug effects that are poorly understood. It is easier to
> say 'statin' than it is 'HMG-CoA reductase inhibitor'.
> Unfortunately the definitions are synonymous in medicine
> now, just like 'aspirin' and 'salicylic acid', but are
> incorrect.
>
> As another example, consider the question "When does a
> Dell Computer stop becoming a Dell?". If I purchase a Dell
> to run program HMG-CoA, and remove or add components, so
> that eventually, over time the only thing left from the
> original Dell is the outer case. Is it still a Dell? If
> not, when did it stop being a 'Dell'? Yet the computer
> runs the program HMG-CoA like it did when I first
> purchased it.
>
> So we see a similar trend in 'statins'. When does a statin
> stop being a stain?
>
> If you factor these gradual trends of changing the
> molecular structure for the gain of lowering
> cholesterol, it's a dead end road - going nowhere. Why?
> Because not one single study ever completed has proved
> that elevated cholesterol causes atherosclerosis. Yet
> here we are in 2004 with a firmly imbedded notion now so
> that it is almost instinctual, that cholesterol is no
> longer associated with atherosclerosis, but actually is
> the cause.
>
> A grave mistake.
Science...puuurrrrrrrrrrrrrrrrr b'adant