Morphine / antioxidant

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1: Pharmacol Res. 2004 Jan;49(1):59-66. Related Articles, Links

In vitro antioxidant properties of morphine.

Gulci;n I, Beydemi;r S, Alici HA, Elmastas M, Buyukokuroglu ME.

Department of Chemistry, Science and Arts Faculty, Ataturk University, 25240, Erzurum, Turkey

Morphine is implicated in diverse functions, from development to immune modulation in the central
and peripheral nervous systems. It has also been used extensively in the clinical management of
pain due to its potent analgesic effect. This study was designed to evaluate the in vitro
antioxidant capacity of morphine using different antioxidant tests, including total antioxidant
activity, reducing power, free radical scavenging, superoxide anion radical scavenging, hydrogen
peroxide scavenging and metal chelating activities. Morphine exhibited strong total antioxidant
activity. The concentrations of 25, 50 and 75microgml(-1) of morphine showed 79.1, 84.3 and 92.3%
inhibition on peroxidation of linoleic acid emulsion, respectively. On the other hand, at
75microgml(-1) concentration of standard antioxidant, such as butylated hydroxyanisole (BHA),
butylated hydroxytoluene (BHT) and alpha-tocopherol, exhibited 88.7, 94.5 and 70.4% inhibition on
peroxidation of linoleic acid emulsion, respectively. In addition, morphine had effective reducing
power, free radical scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging
and metal chelating activities at the same concentrations (25, 50 and 75microgml(-1)). These
various antioxidant activities were compared to standard antioxidants such as BHA, BHT and
alpha-tocopherol.

PMID: 14597153 [PubMed - as supplied by publisher]

Maybe, while they are at it, they can check for anti-oxydant properties in strychnine, heroin,
nicotine, cocaine, digitalis, ergot, etc. Then we'll have a comprehensive of anti-oxydants that we
will never be able to use.

What a waste of valuable research money.

TC

"tcomeau" <[email hidden]> wrote in message
"]news:[email hidden]...

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[email hidden] (doe) wrote in message

news:<[email hidden]>...

Quoted message said:

Quoted message said:

1: Pharmacol Res. 2004 Jan;49(1):59-66. Related Articles, Links

In vitro antioxidant properties of morphine.

Gulci;n I, Beydemi;r S, Alici HA, Elmastas M, Buyukokuroglu ME.

Department of Chemistry, Science and Arts Faculty, Ataturk University,

25240,

Quoted message said:

Quoted message said:

Erzurum, Turkey

Morphine is implicated in diverse functions, from development to immune modulation in the
central and peripheral nervous systems. It has also

been used

Quoted message said:

Quoted message said:

extensively in the clinical management of pain due to its potent

analgesic

Quoted message said:

Quoted message said:

effect. This study was designed to evaluate the in vitro antioxidant

capacity

Quoted message said:

Quoted message said:

of morphine using different antioxidant tests, including total

antioxidant

Quoted message said:

Quoted message said:

activity, reducing power, free radical scavenging, superoxide anion

radical

Quoted message said:

Quoted message said:

scavenging, hydrogen peroxide scavenging and metal chelating activities. Morphine exhibited
strong total antioxidant activity. The concentrations

of 25,

Quoted message said:

Quoted message said:

50 and 75microgml(-1) of morphine showed 79.1, 84.3 and 92.3% inhibition

on

Quoted message said:

Quoted message said:

peroxidation of linoleic acid emulsion, respectively. On the other hand,

at

Quoted message said:

Quoted message said:

75microgml(-1) concentration of standard antioxidant, such as butylated hydroxyanisole (BHA),
butylated hydroxytoluene (BHT) and

alpha-tocopherol,

Quoted message said:

Quoted message said:

exhibited 88.7, 94.5 and 70.4% inhibition on peroxidation of linoleic

acid

Quoted message said:

Quoted message said:

emulsion, respectively. In addition, morphine had effective reducing

power,

Quoted message said:

Quoted message said:

free radical scavenging, superoxide anion radical scavenging, hydrogen

peroxide

Quoted message said:

Quoted message said:

scavenging and metal chelating activities at the same concentrations

(25, 50

Quoted message said:

Quoted message said:

and 75microgml(-1)). These various antioxidant activities were compared

to

Quoted message said:

Quoted message said:

standard antioxidants such as BHA, BHT and alpha-tocopherol.

PMID: 14597153 [PubMed - as supplied by publisher]

Maybe, while they are at it, they can check for anti-oxydant properties in strychnine, heroin,
nicotine, cocaine, digitalis, ergot, etc. Then we'll have a comprehensive of anti-oxydants that we
will never be able to use.

What a waste of valuable research money.

TC

Err, TC, morphine is a legal drug frequently prescribed in situations of extreme pain. Nicotine
(patches, not cig- arettes) may prevent Alzheimer's and Parkinson's. Ergot is useful as a
vasoconstrictor for migraine headaches. And so on.

GWC

"George W. Cherry" <[email hidden]> wrote in message
news:<%zEqb.97628$9E1.470426@attbi_s52>...

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"tcomeau" <[email hidden]> wrote in message
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[email hidden] (doe) wrote in message

news:<[email hidden]>...

Quoted message said:

Quoted message said:

1: Pharmacol Res. 2004 Jan;49(1):59-66. Related Articles, Links

In vitro antioxidant properties of morphine.

Gulci;n I, Beydemi;r S, Alici HA, Elmastas M, Buyukokuroglu ME.

Department of Chemistry, Science and Arts Faculty, Ataturk University,

25240,

Quoted message said:

Quoted message said:

Erzurum, Turkey

Morphine is implicated in diverse functions, from development to immune modulation in the
central and peripheral nervous systems. It has also

been used

Quoted message said:

Quoted message said:

extensively in the clinical management of pain due to its potent

analgesic

Quoted message said:

Quoted message said:

effect. This study was designed to evaluate the in vitro antioxidant

capacity

Quoted message said:

Quoted message said:

of morphine using different antioxidant tests, including total

antioxidant

Quoted message said:

Quoted message said:

activity, reducing power, free radical scavenging, superoxide anion

radical

Quoted message said:

Quoted message said:

scavenging, hydrogen peroxide scavenging and metal chelating activities. Morphine exhibited
strong total antioxidant activity. The concentrations

of 25,

Quoted message said:

Quoted message said:

50 and 75microgml(-1) of morphine showed 79.1, 84.3 and 92.3% inhibition

on

Quoted message said:

Quoted message said:

peroxidation of linoleic acid emulsion, respectively. On the other hand,

at

Quoted message said:

Quoted message said:

75microgml(-1) concentration of standard antioxidant, such as butylated hydroxyanisole (BHA),
butylated hydroxytoluene (BHT) and

alpha-tocopherol,

Quoted message said:

Quoted message said:

exhibited 88.7, 94.5 and 70.4% inhibition on peroxidation of linoleic

acid

Quoted message said:

Quoted message said:

emulsion, respectively. In addition, morphine had effective reducing

power,

Quoted message said:

Quoted message said:

free radical scavenging, superoxide anion radical scavenging, hydrogen

peroxide

Quoted message said:

Quoted message said:

scavenging and metal chelating activities at the same concentrations

(25, 50

Quoted message said:

Quoted message said:

and 75microgml(-1)). These various antioxidant activities were compared

to

Quoted message said:

Quoted message said:

standard antioxidants such as BHA, BHT and alpha-tocopherol.

PMID: 14597153 [PubMed - as supplied by publisher]

Maybe, while they are at it, they can check for anti-oxydant properties in strychnine, heroin,
nicotine, cocaine, digitalis, ergot, etc. Then we'll have a comprehensive of anti-oxydants that
we will never be able to use.

What a waste of valuable research money.

TC

Err, TC, morphine is a legal drug frequently prescribed in situations of extreme pain. Nicotine
(patches, not cig- arettes) may prevent Alzheimer's and Parkinson's. Ergot is useful as a
vasoconstrictor for migraine headaches. And so on.

GWC

Morphine is a pain-killer of last resort. It is highly addictive. Nicotine and ergot are considered
poisons. These substances all represent over-kill and sheer absurdity to consider them for their
anti-oxidant properties.

TC

"tcomeau" <[email hidden]> wrote in message
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"George W. Cherry" <[email hidden]> wrote in

message news:<%zEqb.97628$9E1.470426@attbi_s52>...

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"tcomeau" <[email hidden]> wrote in message
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[email hidden] (doe) wrote in message

news:<[email hidden]>...

Quoted message said:

> 1: Pharmacol Res. 2004 Jan;49(1):59-66. Related Articles, Links
>
>
> In vitro antioxidant properties of morphine.
>
> Gulci;n I, Beydemi;r S, Alici HA, Elmastas M, Buyukokuroglu ME.
>
> Department of Chemistry, Science and Arts Faculty, Ataturk

University,

Quoted message said:

Quoted message said:

25240,

Quoted message said:

> Erzurum, Turkey
>
> Morphine is implicated in diverse functions, from development to

immune

Quoted message said:

Quoted message said:

Quoted message said:

> modulation in the central and peripheral nervous systems. It has

also

Quoted message said:

Quoted message said:

been used

Quoted message said:

> extensively in the clinical management of pain due to its potent

analgesic

Quoted message said:

> effect. This study was designed to evaluate the in vitro antioxidant

capacity

Quoted message said:

> of morphine using different antioxidant tests, including total

antioxidant

Quoted message said:

> activity, reducing power, free radical scavenging, superoxide anion

radical

Quoted message said:

> scavenging, hydrogen peroxide scavenging and metal chelating

activities.

Quoted message said:

Quoted message said:

Quoted message said:

> Morphine exhibited strong total antioxidant activity. The

concentrations

Quoted message said:

Quoted message said:

of 25,

Quoted message said:

> 50 and 75microgml(-1) of morphine showed 79.1, 84.3 and 92.3%

inhibition

Quoted message said:

Quoted message said:

on

Quoted message said:

> peroxidation of linoleic acid emulsion, respectively. On the other

hand,

Quoted message said:

Quoted message said:

at

Quoted message said:

> 75microgml(-1) concentration of standard antioxidant, such as

butylated

Quoted message said:

Quoted message said:

Quoted message said:

> hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and

alpha-tocopherol,

Quoted message said:

> exhibited 88.7, 94.5 and 70.4% inhibition on peroxidation of

linoleic

Quoted message said:

Quoted message said:

acid

Quoted message said:

> emulsion, respectively. In addition, morphine had effective reducing

power,

Quoted message said:

> free radical scavenging, superoxide anion radical scavenging,

hydrogen

Quoted message said:

Quoted message said:

peroxide

Quoted message said:

> scavenging and metal chelating activities at the same concentrations

(25, 50

Quoted message said:

> and 75microgml(-1)). These various antioxidant activities were

compared

Quoted message said:

Quoted message said:

to

Quoted message said:

> standard antioxidants such as BHA, BHT and alpha-tocopherol.
>
> PMID: 14597153 [PubMed - as supplied by publisher]
>

Maybe, while they are at it, they can check for anti-oxydant properties in strychnine, heroin,
nicotine, cocaine, digitalis, ergot, etc. Then we'll have a comprehensive of anti-oxydants
that we will never be able to use.

What a waste of valuable research money.

TC

Err, TC, morphine is a legal drug frequently prescribed in situations of extreme pain. Nicotine
(patches, not cig- arettes) may prevent Alzheimer's and Parkinson's. Ergot is useful as a
vasoconstrictor for migraine headaches. And so on.

GWC

Morphine is a pain-killer of last resort. It is highly addictive. Nicotine and ergot are
considered poisons. These substances all represent over-kill and sheer absurdity to consider them
for their anti-oxidant properties.

TC

I was in Brooke Army Hospital for about six weeks during which I received morphine frequently. I
hated the morphine for what it did to my concentration. I was bored and wanted to read and the
morphine in- terfered with my concentration. I couldn't wait to get off morphine.

GWC