Morphine / antioxidant

"doe" <[email hidden]> wrote in message
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1: Pharmacol Res. 2004 Jan;49(1):59-66. Related Articles, Links

In vitro antioxidant properties of morphine.

Gulci;n I, Beydemi;r S, Alici HA, Elmastas M, Buyukokuroglu ME.

Department of Chemistry, Science and Arts Faculty, Ataturk University,

25240,

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Erzurum, Turkey

Morphine is implicated in diverse functions, from development to immune modulation in the central
and peripheral nervous systems. It has also been

used

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extensively in the clinical management of pain due to its potent analgesic effect. This study was
designed to evaluate the in vitro antioxidant

capacity

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of morphine using different antioxidant tests, including total antioxidant activity, reducing
power, free radical scavenging, superoxide anion

radical

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scavenging, hydrogen peroxide scavenging and metal chelating activities. Morphine exhibited strong
total antioxidant activity. The concentrations

of 25,

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50 and 75microgml(-1) of morphine showed 79.1, 84.3 and 92.3% inhibition

on

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peroxidation of linoleic acid emulsion, respectively. On the other hand,

at

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75microgml(-1) concentration of standard antioxidant, such as butylated hydroxyanisole (BHA),
butylated hydroxytoluene (BHT) and alpha-tocopherol, exhibited 88.7, 94.5 and 70.4% inhibition on
peroxidation of linoleic acid emulsion, respectively. In addition, morphine had effective reducing

power,

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free radical scavenging, superoxide anion radical scavenging, hydrogen

peroxide

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scavenging and metal chelating activities at the same concentrations (25,

50

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and 75microgml(-1)). These various antioxidant activities were compared to standard antioxidants
such as BHA, BHT and alpha-tocopherol.

PMID: 14597153 [PubMed - as supplied by publisher]

Even though morphine is refined from a plant that has been used in herbal medicine since prehistoric
time, its use as a dietary supplement for its antioxidant properties cannot be recommended. The CNS
depressant effects of morphine can, at high doses, suppress respiration to the point where hypoxia
makes antioxidants moot.

;o) Rich

(doe) said:

In vitro antioxidant properties of morphine.

"In vitro" = in a test tube. Its action in living systems is dominated by the effects on the brain
and the respiratory depressant effect.

If you want anti-oxidants, eat fresh fruits.

Tsu Dho Nimh

--
When businesses invoke the "protection of consumers," it's a lot like politicians invoking morality
and children - grab your wallet and/or your kid and run for your life.

Rich Shewmaker said:

Even though morphine is refined from a plant that has been used in herbal medicine since
prehistoric time, its use as a dietary supplement for its antioxidant properties cannot be
recommended. The CNS depressant effects of morphine can, at high doses, suppress respiration to the
point where hypoxia makes antioxidants moot.

;o) Rich

Not to mention the depression of the GI tract.
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