Prostaglandins Leukot Essent Fatty Acids. 2005 May;72(5):357-62.
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N-6 polynsaturated fatty acids confer hemodynamic stability in an
experimental model of multiple trauma.
Efstathopoulos N, Bathrellos E, Giamarellos-Bourboulis EJ, Lazarettos
J, Papalois A, Grecka P, Nikolaou V.
2nd Department of Orthopaedics, University of Athens, Medical School,
Greece.
Immunonutrition with diets enriched in polyunsaturated fatty acids
(PUFAs) are becoming mandatory for multiple trauma patients. Solutions
containing single n-6 PUFAs were administered intravenously in an
experimental model of trauma. Thirty-five rabbits were studied; 13
controls; 10 administered gamma-linolenic acid (GLA) 30 min after
fracture of the right femor; and 12 arachidonic acid (AA). Systolic,
diastolic and mean arterial pressures and heart rate were recorded;
serum levels of tumor necrosis factor-alpha (TNFalpha), malondialdehyde
(MDA) and nitrate were estimated before and after therapy. Mean
survival of controls, of animals treated with GLA and of animals
treated with AA was 0.80, 1.41 and 3.60 days, respectively.
Administration of PUFAs induced higher levels of blood pressure; that
of AA decreased serum TNFalpha and tissue bacterial load compared to
controls. Intravenous administration of n-6 PUFAs conferred hemodynamic
stability and increased survival in a model of trauma rendering further
research mandatory.
PMID: 15850717 [PubMed - in process]
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