neurodegenerative disease / iron



D

Doe

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J Neurochem. 2004 Mar;88(6):1555-69. Links

Cell signaling pathways in the neuroprotective actions of
the green tea polyphenol (-)-epigallocatechin-3-gallate:
implications for neurodegenerative diseases.

Mandel S, Weinreb O, Amit T, Youdim MB.

Eve Topf and USA National Parkinson Foundation Centers of
Excellence for Neurodegenerative Diseases Research and
Department of Pharmacology, Technion-Faculty of Medicine,
Haifa, Israel.

Accumulating evidence supports the hypothesis that brain
iron misregulation and oxidative stress (OS), resulting in
reactive oxygen species (ROS) generation from H2O2 and
inflammatory processes, trigger a cascade of events leading
to apoptotic/necrotic cell death in neurodegenerative
disorders, such as Parkinson's (PD), Alzheimer's (AD) and
Huntington's diseases, and amyotrophic lateral sclerosis
(ALS). Thus, novel therapeutic approaches aimed at
neutralization of OS-induced neurotoxicity, support the
application of ROS scavengers, transition metals (e.g. iron
and copper) chelators and non-vitamin natural antioxidant
polyphenols, in monotherapy, or as part of antioxidant
cocktail formulation for these diseases. Both experimental
and epidemiological evidence demonstrate that flavonoid
polyphenols, particularly from green tea and blueberries,
improve age-related cognitive decline and are
neuroprotective in models of PD, AD and cerebral
ischemia/reperfusion injuries. However, recent studies
indicate that the radical scavenger property of green tea
polyphenols is unlikely to be the sole explanation for their
neuroprotective capacity and in fact, a wide spectrum of
cellular signaling events may well account for their
biological actions. In this article, the currently
established mechanisms involved in the beneficial health
action and emerging studies concerning the putative novel
molecular neuroprotective activity of green tea and its
major polyphenol (-)-epigallocatechin-3-gallate (EGCG), will
be reviewed and discussed.

PMID: 15009657 [PubMed - in process]

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Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
 
Ah, the central point to be learned is that genetic based
conditions which cause misregulation of iron can be a
problem. How is this different then any genetic based
condition which causes misregulation of many things,ex.
glucose in diabetics. I t is not that they consume iron but
they are preconditioned to have misregulation of it. Iron is
itself an antioxident and helps kill germs. Let's keep our
reality ducks in a row if you please.

>J Neurochem. 2004 Mar;88(6):1555-69. Links
>
>
>Cell signaling pathways in the neuroprotective actions of
>the green tea polyphenol (-)-epigallocatechin-3-gallate:
>implications for neurodegenerative diseases.
>
>Mandel S, Weinreb O, Amit T, Youdim MB.
>
>Eve Topf and USA National Parkinson Foundation Centers of
>Excellence for Neurodegenerative Diseases Research and
>Department of Pharmacology, Technion-Faculty of Medicine,
>Haifa, Israel.
>
>Accumulating evidence supports the hypothesis that brain
>iron misregulation and oxidative stress (OS), resulting in
>reactive oxygen species (ROS) generation from H2O2 and
>inflammatory processes, trigger a cascade of events leading
>to apoptotic/necrotic cell death in neurodegenerative
>disorders, such as Parkinson's (PD), Alzheimer's (AD) and
>Huntington's diseases, and amyotr lateral sclerosis (ALS).
>Thus, novel therapeutic approaches aimed at neutralization
>of OS-induced neurotoxicity, support the application of ROS
>scavengers, transition metals (e.g. iron and copper)
>chelators and non-vitamin natural antioxidant polyphenols,
>in monotherapy, or as part of antioxidant cocktail
>formulation for these diseases. Both experimental and
>epidemiological evidence demonstrate that flavonoid
>polyphenols, particularly from green tea and blueberries,
>improve age-related cognitive decline and are
>neuroprotective in models of PD, AD and cerebral
>ischemia/reperfusion injuries. However, recent studies
>indicate that the radical scavenger property of green tea
>polyphenols is unlikely to be the sole explanation for
>their neuroprotective capacity and in fact, a wide spectrum
>of cellular signaling events may well account for their
>biological actions. In this article, the currently
>established mechanisms involved in the beneficial health
>action and emerging studies concerning the putative novel
>molecular neuroprotective activity of green tea and its
>major polyphenol (-)-epigallocatechin-3-gallate (EGCG),
>will be reviewed and discussed.
>
>PMID: 15009657 [PubMed - in process]
>
>-----------------------------------------------------------
>---------------
>------
>
>Who loves ya. Tom Jesus Was A Vegetarian!
>http://jesuswasavegetarian.7h.com Man Is A Herbivore!
>http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
>PEOPLE WALKING
>http://pages.ivillage.com/ironjustice/deadpeoplewalking
 
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