neurodegenerative disease / iron

Discussion in 'Food and nutrition' started by Doe, Mar 11, 2004.

  1. Doe

    Doe Guest

    J Neurochem. 2004 Mar;88(6):1555-69. Links

    Cell signaling pathways in the neuroprotective actions of
    the green tea polyphenol (-)-epigallocatechin-3-gallate:
    implications for neurodegenerative diseases.

    Mandel S, Weinreb O, Amit T, Youdim MB.

    Eve Topf and USA National Parkinson Foundation Centers of
    Excellence for Neurodegenerative Diseases Research and
    Department of Pharmacology, Technion-Faculty of Medicine,
    Haifa, Israel.

    Accumulating evidence supports the hypothesis that brain
    iron misregulation and oxidative stress (OS), resulting in
    reactive oxygen species (ROS) generation from H2O2 and
    inflammatory processes, trigger a cascade of events leading
    to apoptotic/necrotic cell death in neurodegenerative
    disorders, such as Parkinson's (PD), Alzheimer's (AD) and
    Huntington's diseases, and amyotrophic lateral sclerosis
    (ALS). Thus, novel therapeutic approaches aimed at
    neutralization of OS-induced neurotoxicity, support the
    application of ROS scavengers, transition metals (e.g. iron
    and copper) chelators and non-vitamin natural antioxidant
    polyphenols, in monotherapy, or as part of antioxidant
    cocktail formulation for these diseases. Both experimental
    and epidemiological evidence demonstrate that flavonoid
    polyphenols, particularly from green tea and blueberries,
    improve age-related cognitive decline and are
    neuroprotective in models of PD, AD and cerebral
    ischemia/reperfusion injuries. However, recent studies
    indicate that the radical scavenger property of green tea
    polyphenols is unlikely to be the sole explanation for their
    neuroprotective capacity and in fact, a wide spectrum of
    cellular signaling events may well account for their
    biological actions. In this article, the currently
    established mechanisms involved in the beneficial health
    action and emerging studies concerning the putative novel
    molecular neuroprotective activity of green tea and its
    major polyphenol (-)-epigallocatechin-3-gallate (EGCG), will
    be reviewed and discussed.

    PMID: 15009657 [PubMed - in process]

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    Who loves ya. Tom Jesus Was A Vegetarian!
    http://jesuswasavegetarian.7h.com Man Is A Herbivore!
    http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
    PEOPLE WALKING
    http://pages.ivillage.com/ironjustice/deadpeoplewalking
     
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  2. markd

    markd Guest

    Ah, the central point to be learned is that genetic based
    conditions which cause misregulation of iron can be a
    problem. How is this different then any genetic based
    condition which causes misregulation of many things,ex.
    glucose in diabetics. I t is not that they consume iron but
    they are preconditioned to have misregulation of it. Iron is
    itself an antioxident and helps kill germs. Let's keep our
    reality ducks in a row if you please.

    >J Neurochem. 2004 Mar;88(6):1555-69. Links
    >
    >
    >Cell signaling pathways in the neuroprotective actions of
    >the green tea polyphenol (-)-epigallocatechin-3-gallate:
    >implications for neurodegenerative diseases.
    >
    >Mandel S, Weinreb O, Amit T, Youdim MB.
    >
    >Eve Topf and USA National Parkinson Foundation Centers of
    >Excellence for Neurodegenerative Diseases Research and
    >Department of Pharmacology, Technion-Faculty of Medicine,
    >Haifa, Israel.
    >
    >Accumulating evidence supports the hypothesis that brain
    >iron misregulation and oxidative stress (OS), resulting in
    >reactive oxygen species (ROS) generation from H2O2 and
    >inflammatory processes, trigger a cascade of events leading
    >to apoptotic/necrotic cell death in neurodegenerative
    >disorders, such as Parkinson's (PD), Alzheimer's (AD) and
    >Huntington's diseases, and amyotr lateral sclerosis (ALS).
    >Thus, novel therapeutic approaches aimed at neutralization
    >of OS-induced neurotoxicity, support the application of ROS
    >scavengers, transition metals (e.g. iron and copper)
    >chelators and non-vitamin natural antioxidant polyphenols,
    >in monotherapy, or as part of antioxidant cocktail
    >formulation for these diseases. Both experimental and
    >epidemiological evidence demonstrate that flavonoid
    >polyphenols, particularly from green tea and blueberries,
    >improve age-related cognitive decline and are
    >neuroprotective in models of PD, AD and cerebral
    >ischemia/reperfusion injuries. However, recent studies
    >indicate that the radical scavenger property of green tea
    >polyphenols is unlikely to be the sole explanation for
    >their neuroprotective capacity and in fact, a wide spectrum
    >of cellular signaling events may well account for their
    >biological actions. In this article, the currently
    >established mechanisms involved in the beneficial health
    >action and emerging studies concerning the putative novel
    >molecular neuroprotective activity of green tea and its
    >major polyphenol (-)-epigallocatechin-3-gallate (EGCG),
    >will be reviewed and discussed.
    >
    >PMID: 15009657 [PubMed - in process]
    >
    >-----------------------------------------------------------
    >---------------
    >------
    >
    >Who loves ya. Tom Jesus Was A Vegetarian!
    >http://jesuswasavegetarian.7h.com Man Is A Herbivore!
    >http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
    >PEOPLE WALKING
    >http://pages.ivillage.com/ironjustice/deadpeoplewalking
     
  3. Manky Badger

    Manky Badger Guest

  4. Manky Badger

    Manky Badger Guest

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