New drug may lead to one-stop diabetes pill The Times of India Friday, July 18, 2003 Washington (Reuters) - Researchers said on Thursday they had found a new class of drugs that might attack diabetes on more than one front -- and that could be taken as a pill. They have only tested the drugs in rats and mice so far, meaning years of development are needed, but said the medications could offer an alternative to some of the drugs that many diabetes patients must take. ''At this point in time, this type of drug will not allow us to replace insulin,'' cautioned Joseph Grippo, a vice- president at Roche who led the research. ''We are targeting type-II diabetes populations before they get to insulin,'' Grippo said. Patients with type II diabetes make too little insulin and have too much glucose in their systems. The new compound stimulates the pancreas to release more insulin and keeps the liver from producing too much glucose. Diabetes patients often take two drugs for this -- sulfonylureas and metformin. Type-II diabetes, which affects an estimated 135 million people worldwide, often requires a range of drugs to be kept under control. Roche's drug is a glucokinase enzyme activator. It acts on GK, an enzyme that diabetes researchers have known about for years. ''The glucokinase enzyme is the body's first step in breaking down or metabolizing glucose,'' Grippo said. ''When the enzyme is functioning normally, GK helps the body maintain glucose levels by controlling the release of insulin from the pancreas as well as the disposal of glucose in the liver.'' In 1992 researchers discovered a mutation in the GK gene caused a certain type of diabetes called maturity onset diabetes of the young type 2. Grippo said it did not seem like a good target for a drug. ''In order to make it effective you have to activate the enzyme. Most drugs inhibit enzymes,'' Grippo said. Roche scientists found a compound that seemed like it would activate GK. They hope to start human trials within a year. Read the complete news at: http://www.timesofindia.com News Plus http://www.mantra.com/newsplus Jai Maharaj http://www.mantra.com/jai Om Shanti Panchaang for 20 Ashadh 5104, Friday, July 18, 2003: Shubhanu Nama Samvatsare Dakshinaya Nartana Ritau Kark Mase Krishna Pakshe Shukr Vasara Yuktayam Poorvaprostapad-Uttaraprostapad Nakshatr Shobhan-Atiganda Yog Gar-Vanij Karan Shasthi Yam Tithau Hindu Holocaust Museum http://www.mantra.com/holocaust Hindu life, principles, spirituality and philosophy http://www.hindu.org http://www.hindunet.org The truth about Islam and Muslims http://www.flex.com/~jai/satyamevajayate o Not for commercial use. Solely to be fairly used for the educational purposes of research and open discussion. The contents of this post may not have been authored by, and do not necessarily represent the opinion of the poster. The contents are protected by copyright law and the exemption for fair use of copyrighted works. o If you send private e-mail to me, it will likely not be read, considered or answered if it does not contain your full legal name, current e-mail and postal addresses, and live-voice telephone number. o Posted for information and discussion. Views expressed by others are not necessarily those of the poster.