New Scientist interview with Dr. C. Kenyon



DZ <[email protected]> wrote in message news:<[email protected]>...
> galya <[email protected]> wrote:
> > http://www.newscientist.com/opinion/opinterview.jsp;jsessionid=KEDEFONLCKFB?id=ns24171
>
> Which of the insuline receptors in humans are evolutionary homologous to C. elegans daf-2?
>
> DZ

Daf-2 is one of three (I think) "longevity genes" that determine life span in C. elegans. I am not
sure about the homologies in humans but the encoded homologous proteins in humans are those that
regulate insulin and insulin growth factor I (IGF-I) .

The following is a paragraph from the introduction to the full paper (free) by Wolkow CA, Munoz MJ,
Riddle DL, Ruvkun G. Insulin receptor substrate and p55 orthologous adaptor proteins function in the
Caenorhabditis elegans daf-2/insulin-like signaling pathway. J Biol Chem. 2002 Dec
20;277(51):49591-7. Epub 2002 Oct 18. PMID: 12393910 [PubMed - indexed for MEDLINE] (@:
http://www.jbc.org/cgi/content/full/277/51/49591)

<<An insulin-like signaling pathway controls development and lifespan in Caenorhabditis elegans
(1-3). Genetic studies have shown that the
C. elegans insulin-like pathway utilizes many of the same components as the human insulin and
insulin-like growth factor (IGF-I)1 pathways.
D. elegans insulin-like signaling requires the genes daf-2, encoding an insulin/IGF-I receptor-like
protein, age-1, a homolog of vertebrate p110 catalytic subunits of phosphoinositide 3-kinase
(PI3K), akt-1 and akt-2, encoding AKT/protein kinase B-like proteins activated by the
phospholipid products of PI3K, and pdk-1, encoding a PDK-1-like kinase also required for
AKT/protein kinase B activation (1, 4-6).>>

galya
 
galya <[email protected]> wrote:
> DZ <[email protected]> wrote
> > galya <[email protected]> wrote:
> > > http://www.newscientist.com/opinion/opinterview.jsp;jsessionid=KEDEFONLCKFB?id=ns24171
> >
> > Which of the insuline receptors in humans are evolutionary homologous to C. elegans daf-2?

> Daf-2 is one of three (I think) "longevity genes" that determine life span in C. elegans. I am
> not sure about the homologies in humans but the encoded homologous proteins in humans are those
> that regulate insulin and insulin growth factor I (IGF-I) .

Great. There appear to be some epidemiological studies of these genes on humans: e.g.
http://tinyurl.com/rgx3 (associations of insulin receptor polymorphisms with longevity). And more by
Barbieri, Bonafe, et al.

DZ

> The following is a paragraph from the introduction to the full paper (free) by Wolkow CA, Munoz
> MJ, Riddle DL, Ruvkun G. Insulin receptor substrate and p55 orthologous adaptor proteins function
> in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. J Biol Chem. 2002 Dec
> 20;277(51):49591-7. Epub 2002 Oct 18. PMID: 12393910 [PubMed - indexed for MEDLINE] (@:
> http://www.jbc.org/cgi/content/full/277/51/49591)
>
> <<An insulin-like signaling pathway controls development and lifespan in Caenorhabditis elegans
> (1-3). Genetic studies have shown that the
> C. elegans insulin-like pathway utilizes many of the same components as the human insulin and
> insulin-like growth factor (IGF-I)1 pathways.
> C. elegans insulin-like signaling requires the genes daf-2, encoding an insulin/IGF-I
> receptor-like protein, age-1, a homolog of vertebrate p110 catalytic subunits of
> phosphoinositide 3-kinase (PI3K), akt-1 and akt-2, encoding AKT/protein kinase B-like proteins
> activated by the phospholipid products of PI3K, and pdk-1, encoding a PDK-1-like kinase also
> required for AKT/protein kinase B activation (1, 4-6).>>
>
> galya

--
Wheel discovery department
 
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