NEW WAY TO KEEP STROKE AT BAY

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Dr. Jai Maharaj

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New way to keep stroke at bay

ANI
The Times of India
Wednesday, July 2, 2003

Washington - Latest research may soon pave the way for
more effective prevention of stroke. An experiment on
rats has successfully proved that a new non-invasive way
can help keep stroke at bay.

The method involves injecting a stimulant agent into rat
brains. This expanded blood vessels and improved blood
flow, researchers reported in the rapid access issue of
Circulation: Journal of the American Heart Association.

Rats treated with the growth-promoting substance
granulocyte macrophage-colony stimulating factor (GM-CSF)
had almost twice as much arteriogenesis, the expansion of
a brain artery, after one week compared to rats given
saline solution. The increase was associated with
improved circulation and accumulation of cells that are
thought to play a key role in artery development.

"To the best of our knowledge, this is the first report
of stimulation of arteriogenesis in the brain," say co-
lead authors Ivo R Buschmann and Hans-Jvrg Busch. Both
are investigators in the Research Group for Experimental
and Clinical Arteriogenesis at Albert Ludwigs University
in Freiburg, Germany.

The findings suggest that growth-stimulating substances
may be a novel alternative to other stroke prevention
strategies, which tend to emphasise surgery and other
invasive techniques that improve blood flow to the
brain, the researchers say.

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