NF-kappa B activation / iron



D

Doe

Guest
Comp Hepatol. 2004 Jan 14;3 Suppl 1:S36. Links

Signaling role of iron in NF-kappa B activation in hepatic macrophages.

Xiong S, She H, Tsukamoto H.

Department of Pathology, Keck School of Medicine, University of Southern California, USA.
[email protected]

Iron is both essential and toxic for cells and impaired iron homeostasis has been shown to cause or
potentiate various forms of liver injury. Research in our laboratory suggests that iron also plays a
pivotal role in intracellular signaling for NF-kappa B activation in hepatic macrophages (HM). Our
results showed: 1) HM from alcohol-fed rats had a increase in the nonheme iron content accompanied
by NF-kappa B activation; 2) iron chelation normalized nonheme iron concentration and blocked
enhanced NF-kappa B activation and TNF-alpha expression in these cells; 3) LPS-induced NF-kappa B
activation was also blocked by iron chelator; 4) iron directly induced TNF-alpha expression via IKK
and NF-kappa B activation in normal HM. We propose that iron acts as an independent proinflammatory
molecule via induction of the intracellular signaling for NF-kappa B activation in HM and primes the
liver for chronic inflammation and injury.

PMID: 14960188 [PubMed - as supplied by publisher]

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Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
 
M

markd

Guest
As it says, iron is also needed for proper health. I posted an article in the last week or so, for
the consideration of Tom and to which he did not respond, showing research where iron was an
unexpected benefit to proper neurological activity; As I recall it was with regard to copper as a
toxic agent. Maybe Tom can look it up and comment uopon it also. But wait, he almost never comments
or expands the info posted into any meaningful larger picture, no doubt thinking his "unique" thesis
so broadly understood that it's implication is obvious .. NOT ..

>Comp Hepatol. 2004 Jan 14;3 Suppl 1:S36. Links
>
>
>Signaling role of iron in NF-kappa B activation in hepatic macrophages.
>
>Xiong S, She H, Tsukamoto H.
>
>Department of Pathology, Keck School of Medicine, University of Southern California, USA.
>[email protected]
>
>Iron is both essential and toxic for cells and impaired iron homeostasis has been shown to cause or
>potentiate various forms of liver injury. Research in our laboratory suggests that iron also plays
>a pivotal role in intracellular signaling for NF-kappa B activation in hepatic macrophages (HM).
>Our results showed: 1) HM from alcohol-fed rats had a increase in the nonheme iron content
>accompanied by NF-kappa B activation; 2) iron chelation normalized nonheme iron concentration and
>blocked enhanced NF-kappa B activation and TNF-alpha expression in these cells; 3) LPS-induced NF-
>kappa B activation was also blocked by iron chelator; 4) iron directly induced TNF-alpha expression
>via IKK and NF-kappa B activation in normal HM. We propose that iron acts as an independent
>proinflammatory molecule via induction of the intracellular signaling for NF-kappa B activation in
>HM and primes the liver for chronic inflammation and injury.
>
>PMID: 14960188 [PubMed - as supplied by publisher]
>
>--------------------------------------------------------------------------
>------
>
>Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore!
>http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING
>http://pages.ivillage.com/ironjustice/deadpeoplewalking
 
D

Doe

Guest
>Subject: Re: NF-kappa B activation / iron
>From: [email protected]
>Date: 2/14/2004 1:20 PM Mountain Standard Time
>Message-id: <[email protected]>
>
>
>As it says, iron is also needed for proper health. I posted an article in the last week or so, for
>the consideration of Tom and to which he did not respond, showing research where iron was an
>unexpected benefit to proper neurological activity; As I recall it was with regard to copper as a
>toxic agent. Maybe Tom can look it up and comment uopon it also. But wait, he almost never comments
>or expands the info posted into any meaningful larger picture, no doubt thinking his "unique"
>thesis so broadly understood that it's implication is obvious .. NOT ..

Maybe you simply didn't understand my .. 'take' .. on .. your .. contributions ..?

Shite ..

I'll spell it for ya ..

S .. H .. I .. T .. E ..

>
>
>>Comp Hepatol. 2004 Jan 14;3 Suppl 1:S36. Links
>>
>>
>>Signaling role of iron in NF-kappa B activation in hepatic macrophages.
>>
>>Xiong S, She H, Tsukamoto H.
>>
>>Department of Pathology, Keck School of Medicine, University of Southern California, USA.
>>[email protected]
>>
>>Iron is both essential and toxic for cells and impaired iron homeostasis has been shown to cause
>>or potentiate various forms of liver injury. Research in our laboratory suggests that iron also
>>plays a pivotal role in intracellular signaling for NF-kappa B activation in hepatic macrophages
>>(HM). Our results showed: 1) HM from alcohol-fed rats had a increase in the nonheme iron
>content
>>accompanied by NF-kappa B activation; 2) iron chelation normalized nonheme
>iron
>>concentration and blocked enhanced NF-kappa B activation and TNF-alpha expression in these cells;
>>3) LPS-induced NF-kappa B activation was also blocked by iron chelator; 4) iron directly induced
>>TNF-alpha expression via
>IKK
>>and NF-kappa B activation in normal HM. We propose that iron acts as an independent
>>proinflammatory molecule via induction of the intracellular signaling for NF-kappa B activation in
>>HM and primes the liver for chronic inflammation and injury.
>>
>>PMID: 14960188 [PubMed - as supplied by publisher]
>>
>>--------------------------------------------------------------------------
>>------
>>
>>Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
 
M

markd

Guest
Ah, our good friend Tom can be scatological even different languages, no wait, in these days of the
net dictionaries of languages are a dime a dozen; oh drat; we will find something he knows something
about .. WE .. NEED .. ONLY PATIENCE.