R
Roger
Guest
The NF-kappa B appears to be the godfather of genes involved in chemo-resistance of panc cancer
cells. Overexpression of Bcl-XL causes resistance of panc cancer cells to chemo but Bcl-XL is
activated by the NF-kappa B gene.
Here's an abstract that discusses NF-kappa B.
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Annu Rev Immunol. 1996;14:649-83.
The NF-kappa B and I kappa B proteins: new discoveries and insights.
Baldwin AS Jr. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill
27599, USA.
The transcription factor NF-kappa B has attracted widespread attention among researchers in many
fields based on the following: its unusual and rapid regulation, the wide range of genes that it
controls, its central role in immunological processes, the complexity of its subunits, and its
apparent involvement in several diseases. A primary level of control for NF-kappa B is through
interactions with an inhibitor protein called I kappa B. Recent evidence confirms the existence of
multiple forms of I kappa B that appear to regulate NF-kappa B by distinct mechanisms. NF-kappa B
can be activated by exposure of cells to LPS or inflammatory cytokines such as TNF or IL-1, viral
infection or expression of certain viral gene products, UV irradiation, B or T cell activation, and
by other physiological and nonphysiological stimuli. Activation of NF-kappa B to move into the
nucleus is controlled by the targeted phosphorylation and subsequent degradation of I kappa B.
Exciting new research has elaborated several important and unexpected findings that explain
mechanisms involved in the activation of NF-kappa B. In the nucleus, NF-kappa B dimers bind to
target DNA elements and activate transcription of genes encoding proteins involved with immune or
inflammation responses and with cell growth control. Recent data provide evidence that NF-kappa B is
constitutively active in several cell types, potentially playing unexpected roles in regulation of
gene expression. In addition to advances in describing the mechanisms of NF-kappa B activation,
excitement in NF-kappa B research has been generated by the first report of a crystal structure for
one form of NF-kappa B, the first gene knockout studies for different forms of NF-kB and of I kappa
B, and the implications for therapies of diseases thought to involve the inappropriate activation of
NF-kappa B.
cells. Overexpression of Bcl-XL causes resistance of panc cancer cells to chemo but Bcl-XL is
activated by the NF-kappa B gene.
Here's an abstract that discusses NF-kappa B.
------
Annu Rev Immunol. 1996;14:649-83.
The NF-kappa B and I kappa B proteins: new discoveries and insights.
Baldwin AS Jr. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill
27599, USA.
The transcription factor NF-kappa B has attracted widespread attention among researchers in many
fields based on the following: its unusual and rapid regulation, the wide range of genes that it
controls, its central role in immunological processes, the complexity of its subunits, and its
apparent involvement in several diseases. A primary level of control for NF-kappa B is through
interactions with an inhibitor protein called I kappa B. Recent evidence confirms the existence of
multiple forms of I kappa B that appear to regulate NF-kappa B by distinct mechanisms. NF-kappa B
can be activated by exposure of cells to LPS or inflammatory cytokines such as TNF or IL-1, viral
infection or expression of certain viral gene products, UV irradiation, B or T cell activation, and
by other physiological and nonphysiological stimuli. Activation of NF-kappa B to move into the
nucleus is controlled by the targeted phosphorylation and subsequent degradation of I kappa B.
Exciting new research has elaborated several important and unexpected findings that explain
mechanisms involved in the activation of NF-kappa B. In the nucleus, NF-kappa B dimers bind to
target DNA elements and activate transcription of genes encoding proteins involved with immune or
inflammation responses and with cell growth control. Recent data provide evidence that NF-kappa B is
constitutively active in several cell types, potentially playing unexpected roles in regulation of
gene expression. In addition to advances in describing the mechanisms of NF-kappa B activation,
excitement in NF-kappa B research has been generated by the first report of a crystal structure for
one form of NF-kappa B, the first gene knockout studies for different forms of NF-kB and of I kappa
B, and the implications for therapies of diseases thought to involve the inappropriate activation of
NF-kappa B.