In article<
[email protected]>, John H.
>
>"Dave Bird" <
[email protected]> wrote in message
news[email protected]...
>> In >Looking at your words "the (conscious) choice not to exercise", I think you have the wrong
>> end of the stick: there isn't one. What causes the conscious choice not to exercise if you
>> are lying on your bed with a severe dose of influenza? You feel exhausted and weak, you
>> haven't the energy, and you JUST DON'T FEEL LIKE getting up and rushing around. That's the
>> "choice" you feel like making. Not surprising, really, as your brain is in a fairly altered
>> state. Most of these viruses are dopamine lowering. You feel like you could really murder a
>> dose of mild opiate to blank the dull ache in the centre of your back which has spread into
>> your limbs, and dry up all the saliva and mucus pouring out of you.
>
>Dopamine may well be a downstream effect but with respect to viruses and systemic inflammation a
>number of other factors need to be taken into account.
>
>1.
>
>Tnf a released during fever has the effect of downregulating G protein coupling thereby reducing
>overall cerebral metabolic activity. This effect on G proteins, I think, will impact on Da
>production but Da itself is only one player in the field.
I'm only a piker at this, but... dopamine is useful in resisting viral breakthrough of the cell
wall, and some viruses have adapted to depress dopamine levels to make their life easier, the drug
Amantidine is useful against flu viruses (if caught within 2 or 3 days of initial infection,
especially when there is a difficulty with other treatments)
I didn't enter the whole area of immune activation via interleukins causing physical and mental
slowdown, such as I know of it.
>
>2.
>
>il 1 released under a wide variety of stressors and can generate NO via iNOS. This impacts on a
>number of metabolic processes but more particularly excess NO can inhibit neuronal energy
>production via NO competing with O2 for occupation on the electron chain transport elements. As il
>1 and tnfa are often released concurrently, this constitutes a double whammy on cerebral
>metabolism.
>
>3.
>
>Immunological activation will lead to increased IDO production by various immune cells including
>microglia. IDO catabolizes tryptophan (useful in fighting microbes which often need that amino) and
>this may be why people on interferon therapy(hep c and MS) and cytokine therapy (cancer) experience
>depression. Robbed of extra cellular tryptophan, serotonin synthesis is inhibited.
>
>4.
>
>The generic pain often experienced in fevers is via cox 2 generation, many painkillers are cox 2
>inhibitors. Again, immunological activation generally raises cox 2 levels in a variety of cells.
Um, newer ones are COX2 inhibitors I think. I'm not sure, your knowledge is mostly ahead of mine.
Your advice is very sensible though. In sum, the changes caused by olanzapine will cause
difficulties not just metabolically (fat which used to be excreted is now deposited) but
behaviourally (a lot of things will be making you feel less like exercise), and it needs systematic
effort and self-training to overcome these barriers: you don't just decide and reach it without
considerable effort.
>
>---
>
>You can get all muddled up trying to understand the weight gain in relation to your drug regime. I
>suggest an alternative approach.
>
>Exercise in the morning, light to moderate, as exercise increases overall metabolic rate and if
>intense enough will maintain the increase for a number of hours.
>
>You could very well be under estimating the amount of sugars, especially via alcohol, think about
>this. Try and do an accurate analysis of your total caloric intake, it can be upsettingly
>surprising sometimes. Fact is: if you reduce your caloric intake and maintain exercise then weight
>must fall. I know this from my gym days, would starve myself and train like mad. Very difficult to
>do, may not be advisable for you, but it works. You need to be bloody determined though ... .
>
>Try to develop a fasting habit. As with caloric restriction, fasting can have significant health
>benefits and both have been demonstrated to have favourable impacts on cerebral health
>(neuroprotective) and metabolism. You see, those old mystics weren't that stupid ... . It takes
>time and in my case at least I now find it very difficult to eat a full meal. Don't eat full meals,
>rather half meals throughout the day. Healthy ones! I think my stomach must have shrunk over the
>years. It will take many months to do this but the effects may well last a very long time. Caloric
>restriction is the only proven method for improving longevity in lab studies. Reducing caloric
>intake doesn't necessarily reduce overall activity. I can easily go for 24 hours without eating,
>and put in a 12 hour day on the books.
>
>Vaguely, I recall reading an abstract indicating that administration of vitamin E can help reduce
>tardive dyskinesia. How is your anti-oxidant status generally? If you are drinking alcohol are you
>taking a vit B group s upplement (another study stated administration of B groups slightly improved
>anti-depressant drug response). L-carnitine supplement may help in weight problems. With regard to
>this paragraph see your doctor first! Eg. in a manic phase, though doubtful, L-carnitine may not be
>such a good idea as it increases ATP production and overall energy availability. Also consider
>omega 3 supplementation, though not demonstrated for bipolar these fats have shown efficacy in a
>number of conditions, including mental health ones.
>
>The choice not to exercise is part of the human condition, trust me you're not unique on this one.
>One way to overcome it is to coax yourself into exercise, beyond a certain level exercise becomes
>natural and fun. I saw this so often at the gym, people became addicted to exercise. But then if
>you like pot that ain't gonna happen. A lot of **** is said about pot but the one thing I have
>noticed in myself and others time and again is that pot makes life too good, who wants to struggle
>when just a cone away is another relaxing evening ... . Damn I've run out again. Maintain the
>meditation, recent research shows it can have significant benefits. One recent study claimed it
>elevated left cerebral activity over right, hence help in ameliorating depression. Also , some
>meditation types boost melatonin production, good endogenous anti oxidant. See, told you those
>mystics weren't that dumb. Tell me, can you meditate in the manic phases? Have your tried
>vispassana meditation during these times? Hmmm, what an interesting show that would be ... .
>
>The comments re moon, weather and sunspot activity are interesting. One of my side projects for a
>number of years now. Something subtle may be going on here but having searched the literature I
>have never been able to find anything convincing. However, on the weather side I'm sure there is
>some subtle effect. No idea why though.
>
>Learn to stay hungry, you'll get used to it.
>
>John H.
>
>PS: No more pot for you sunny Jim! Too dangerous.
>
>> >But with free will, you can overcome this.
>
>If free will is free then explain:
>
>multitude of separated twin studies showing v. similiar preferences re mates, jobs, lifestyles,
>haircuts, political leanings ... . The list goes on and on. Very little of our choices are actually
>"free", often we make choices because of constraints imposed upon us. That doesn't sound like
>freedom to me. "Free will" is a concept that has its origins in religious thinking, particularly
>christianity and 'choosing' salvation; though a brief reading of theology (cf predestination,
>calvinism, arminianism) quickly reveals how much grief the concept of free will has created. "Free
>will" explains nothing about human behaviour, it is essentially a 'black box' concept revealing
>more about our ignorance of our decision making processes than our personal and collective
>awareness of our decision making processes. Free will is one of the greatest straw men ideas of
>history. As the Buddha would say, "Throw it down!"
>
>
>
>
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8====3 (O 0) GROETEN --- PRINTZ XEMU EXTRAWL no real OT has |n| (COMMANDER, FIFTH INVADER FORCE)
ever existed ................................................................. A society without a
religion is like a maniac without a chainsaw.