osmolytes, diabetes, and humans

Discussion in 'Health and medical' started by Frank Roy, Feb 20, 2004.

  1. Frank Roy

    Frank Roy Guest

    In another newsgroup the topic of osmolytes came up when the discussion of supplements of this
    category, such as sorbitol, betaine, and taurine, were mentioned. Since the impact of various
    osmolytes had varied results upon differing cell types and tissues as well as certain types of
    diseases, I decided to narrow the topic down for diabetes using the following search.

    A search across multiple science and health journals resulted in 308 finds for
    osmolytes+diabetes+human. http://tinyurl.com/2fjxo

    Due to my lack of knowledge of physiology and biochemistry, I did not realize how significant this
    topic was to health in general and diabetes in particular. The following article is available in
    full and the text part of the article is 40 pages (the whole article including references used and
    references citing is 176 pages). There is a good index at the beginning of the article. There are a
    number of portions of this article that are especially pertainate to diabetes such as on pages 25
    and 30+. Use your browser find feature for "metabolism, insulin, glucose, glucagon" for instance.

    Functional Significance of Cell Volume Regulatory Mechanisms -
    http://physrev.physiology.org/cgi/content/abstract/78/1/247 "In hepatocytes (liver cells), the
    influence of cell volume on metabolism is one way that insulin and glucagon exert their metabolic
    effects. Insulin increases liver cell volume by activation of Na+/H+ exchange and Na+-K+-2Cl
    cotransport and thus triggers a variety of metabolic functions, including protein and glycogen
    synthesis and inhibition of protein and glycogen degradation." For ions, Na = sodium, K = potassium,
    Cl = cloride.

    Heart: Aldose Reductase Induced by Hyperosmotic Stress Mediates Cardiomyocyte Apoptosis -
    http://www.jbc.org/cgi/content/abstract/278/40/38484

    Kidneys: Osmoregulation of Taurine Transporter Function and Expression in Retinal Pigment
    Epithelial, Ganglion, and Müller Cells http://www.iovs.org/cgi/content/abstract/45/2/694

    The information is available for the taking.

    Cheers, Frank
     
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