Oxidative stress / Fibromyalgia

Discussion in 'Food and nutrition' started by [email protected], Dec 6, 2005.

  1. 1: Rheumatol Int. 2005 Nov 20;:1-13 [Epub ahead of print] Links


    Current concepts in the pathophysiology of fibromyalgia: the potential
    role of oxidative stress and nitric oxide.

    Ozgocmen S, Ozyurt H, Sogut S, Akyol O.

    Division of Rheumatology, Department of Physical Medicine and
    Rehabilitation, Faculty of Medicine, Firat University, 23119, Elazig,
    Turkey, [email protected].

    Fibromyalgia (FM) is a common chronic pain syndrome with an unknown
    etiology. Recent years added new information to our understanding of FM
    pathophysiology. Researches on genetics, biogenic amines,
    neurotransmitters, hypothalamic-pituitary-adrenal axis hormones,
    oxidative stress, and mechanisms of pain modulation, central
    sensitization, and autonomic functions in FM revealed various
    abnormalities indicating that multiple factors and mechanisms are
    involved in the pathogenesis of FM. Oxidative stress and nitric oxide
    may play an important role in FM pathophysiology, however it is still
    not clear whether oxidative stress abnormalities documented in FM are
    the cause or the effect. This should encourage further researches
    evaluating the potential role of oxidative stress and nitric oxide in
    the pathophysiology of FM and the efficacy of antioxidant treatments
    (omega-3 and -6 fatty acids, vitamins and others) in double blind and
    placebo controlled trials. These future researches will enhance our
    understanding of the complex pathophysiology of this disorder.

    PMID: 16328420 [PubMed - as supplied by publisher]

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