Oxidative stress / Fibromyalgia

1: Rheumatol Int. 2005 Nov 20;:1-13 [Epub ahead of print] Links

Current concepts in the pathophysiology of fibromyalgia: the potential
role of oxidative stress and nitric oxide.

Ozgocmen S, Ozyurt H, Sogut S, Akyol O.

Division of Rheumatology, Department of Physical Medicine and
Rehabilitation, Faculty of Medicine, Firat University, 23119, Elazig,
Turkey, [email protected].

Fibromyalgia (FM) is a common chronic pain syndrome with an unknown
etiology. Recent years added new information to our understanding of FM
pathophysiology. Researches on genetics, biogenic amines,
neurotransmitters, hypothalamic-pituitary-adrenal axis hormones,
oxidative stress, and mechanisms of pain modulation, central
sensitization, and autonomic functions in FM revealed various
abnormalities indicating that multiple factors and mechanisms are
involved in the pathogenesis of FM. Oxidative stress and nitric oxide
may play an important role in FM pathophysiology, however it is still
not clear whether oxidative stress abnormalities documented in FM are
the cause or the effect. This should encourage further researches
evaluating the potential role of oxidative stress and nitric oxide in
the pathophysiology of FM and the efficacy of antioxidant treatments
(omega-3 and -6 fatty acids, vitamins and others) in double blind and
placebo controlled trials. These future researches will enhance our
understanding of the complex pathophysiology of this disorder.

PMID: 16328420 [PubMed - as supplied by publisher]


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