Oxidative stress induced by increased dietary iron

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  1. Doe

    Doe Guest

    J Nutr. 2004 Feb;134(2):435-8. Related Articles, Links

    Ascorbic acid does not increase the oxidative stress induced
    by dietary iron in C3H mice.

    Premkumar K, Bowlus CL.

    Department of Internal Medicine, Division of
    Gastroenterology and Hepatology, University of California
    Davis, Davis, CA, USA.

    Iron is a potent prooxidant that can induce lipid
    peroxidation. Ascorbic acid, a potent antioxidant, has
    prooxidant effects in the presence of iron in vitro. We
    investigated whether ascorbic acid and iron co-
    supplementation in ascorbic acid-sufficient mice increases
    hepatic oxidative stress. C3H/He mice were fed diets
    supplemented with iron to 100 mg/kg diet or 300 mg/kg diet
    with or without ascorbic acid (15 g/kg diet) for 3 wk. Liver
    iron concentration, malondialdehyde (MDA), glutathione
    (GSH), glutathione S-transferase (GST), glutathione
    peroxidase (GPx), superoxide dismutase (SOD), and catalase
    (CAT) were measured. High dietary iron increased liver iron
    concentrations slightly (P < 0.05), whereas it dramatically
    increased hepatic MDA (P < 0.0001). Ascorbic acid increased
    MDA but only in mice fed the low-iron diet (P < 0.05). The
    high-iron diet reduced GPx (P < 0.0001), CAT (P < 0.0005),
    SOD (P < 0.05), and GST (P < 0.005) activities regardless of
    ascorbic acid supplementation. In contrast, ascorbic acid
    reduced GPx (P < 0.0001) and CAT (P < 0.05) activities only
    in mice fed the low-iron diet. In conclusion, ascorbic acid
    supplementation can have prooxidant effects in the liver.
    However, ascorbic acid does not further increase the
    oxidative stress induced by increased dietary iron.

    PMID: 14747685 [PubMed - indexed for MEDLINE]

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