Oxidative stress levels are raised in chronic fatigue syndrome

Discussion in 'Food and nutrition' started by [email protected], Aug 9, 2005.

  1. <snip>>
    This is the first time that raised levels of the gold standard measure
    of in vivo oxidative stress (isoprostanes) and their association with
    CFS symptoms have been reported.
    <snip>>


    Free Radic Biol Med. 2005 Sep 1;39(5):584-9. Related Articles, Links


    Oxidative stress levels are raised in chronic fatigue syndrome and are
    associated with clinical symptoms.

    Kennedy G, Spence VA, McLaren M, Hill A, Underwood C, Belch JJ.

    Vascular Diseases Research Unit, The Institute of Cardiovascular
    Research, Ninewells Hospital and Medical School, Dundee, Scotland DD1
    9SY, UK.

    The aetiology of chronic fatigue syndrome (CFS) is unknown; however,
    recent evidence suggests excessive free radical (FR) generation may be
    involved. This study investigated for the first time levels of
    8-iso-prostaglandin-F(2alpha)-isoprostanes alongside other plasma
    markers of oxidative stress in CFS patients and control subjects.
    Forty-seven patients (18 males, 29 females, mean age 48 [19-63] years)
    who fulfilled the Centres for Disease Control classification for CFS
    and 34 healthy volunteers (13 males, 21 females, 46 [19-63] years) were
    enrolled in the study. The CFS patients were divided into two groups;
    one group had previously defined cardiovascular (CV) risk factors of
    obesity and hypertension (group 1) and the second were normotensive and
    nonobese (group 2). Patients had significantly increased levels of
    isoprostanes (group 1, P = 0.007; group 2, P = 0.03, unpaired t test
    compared to controls) and oxidised low-density lipoproteins (group 2, P
    = 0.02) indicative of a FR attack on lipids. CFS patients also had
    significantly lower high-density lipoproteins (group 1, P = 0.011;
    group 2, P = 0.005). CFS symptoms correlated with isoprostane levels,
    but only in group 2 low CV risk CFS patients (isoprostanes correlated
    with; total symptom score P = 0.005; joint pain P = 0.002;
    postexertional malaise P = 0.027, Pearson). This is the first time that
    raised levels of the gold standard measure of in vivo oxidative stress
    (isoprostanes) and their association with CFS symptoms have been
    reported.

    PMID: 16085177 [PubMed - in process]

    --------------------------------------------------------------------------------
    Who loves ya.
    Tom

    Jesus Was A Vegetarian!
    http://jesuswasavegetarian.7h.com
    Man Is A Herbivore!
    http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING
    http://pages.ivillage.com/ironjustice/deadpeoplewalking

    --------------------------------------------------------------------------------
     
    Tags:


Loading...