I
<snip>>
This is the first time that raised levels of the gold standard measure
of in vivo oxidative stress (isoprostanes) and their association with
CFS symptoms have been reported.
<snip>>
Free Radic Biol Med. 2005 Sep 1;39(5):584-9. Related Articles, Links
Oxidative stress levels are raised in chronic fatigue syndrome and are
associated with clinical symptoms.
Kennedy G, Spence VA, McLaren M, Hill A, Underwood C, Belch JJ.
Vascular Diseases Research Unit, The Institute of Cardiovascular
Research, Ninewells Hospital and Medical School, Dundee, Scotland DD1
9SY, UK.
The aetiology of chronic fatigue syndrome (CFS) is unknown; however,
recent evidence suggests excessive free radical (FR) generation may be
involved. This study investigated for the first time levels of
8-iso-prostaglandin-F(2alpha)-isoprostanes alongside other plasma
markers of oxidative stress in CFS patients and control subjects.
Forty-seven patients (18 males, 29 females, mean age 48 [19-63] years)
who fulfilled the Centres for Disease Control classification for CFS
and 34 healthy volunteers (13 males, 21 females, 46 [19-63] years) were
enrolled in the study. The CFS patients were divided into two groups;
one group had previously defined cardiovascular (CV) risk factors of
obesity and hypertension (group 1) and the second were normotensive and
nonobese (group 2). Patients had significantly increased levels of
isoprostanes (group 1, P = 0.007; group 2, P = 0.03, unpaired t test
compared to controls) and oxidised low-density lipoproteins (group 2, P
= 0.02) indicative of a FR attack on lipids. CFS patients also had
significantly lower high-density lipoproteins (group 1, P = 0.011;
group 2, P = 0.005). CFS symptoms correlated with isoprostane levels,
but only in group 2 low CV risk CFS patients (isoprostanes correlated
with; total symptom score P = 0.005; joint pain P = 0.002;
postexertional malaise P = 0.027, Pearson). This is the first time that
raised levels of the gold standard measure of in vivo oxidative stress
(isoprostanes) and their association with CFS symptoms have been
reported.
PMID: 16085177 [PubMed - in process]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
--------------------------------------------------------------------------------
This is the first time that raised levels of the gold standard measure
of in vivo oxidative stress (isoprostanes) and their association with
CFS symptoms have been reported.
<snip>>
Free Radic Biol Med. 2005 Sep 1;39(5):584-9. Related Articles, Links
Oxidative stress levels are raised in chronic fatigue syndrome and are
associated with clinical symptoms.
Kennedy G, Spence VA, McLaren M, Hill A, Underwood C, Belch JJ.
Vascular Diseases Research Unit, The Institute of Cardiovascular
Research, Ninewells Hospital and Medical School, Dundee, Scotland DD1
9SY, UK.
The aetiology of chronic fatigue syndrome (CFS) is unknown; however,
recent evidence suggests excessive free radical (FR) generation may be
involved. This study investigated for the first time levels of
8-iso-prostaglandin-F(2alpha)-isoprostanes alongside other plasma
markers of oxidative stress in CFS patients and control subjects.
Forty-seven patients (18 males, 29 females, mean age 48 [19-63] years)
who fulfilled the Centres for Disease Control classification for CFS
and 34 healthy volunteers (13 males, 21 females, 46 [19-63] years) were
enrolled in the study. The CFS patients were divided into two groups;
one group had previously defined cardiovascular (CV) risk factors of
obesity and hypertension (group 1) and the second were normotensive and
nonobese (group 2). Patients had significantly increased levels of
isoprostanes (group 1, P = 0.007; group 2, P = 0.03, unpaired t test
compared to controls) and oxidised low-density lipoproteins (group 2, P
= 0.02) indicative of a FR attack on lipids. CFS patients also had
significantly lower high-density lipoproteins (group 1, P = 0.011;
group 2, P = 0.005). CFS symptoms correlated with isoprostane levels,
but only in group 2 low CV risk CFS patients (isoprostanes correlated
with; total symptom score P = 0.005; joint pain P = 0.002;
postexertional malaise P = 0.027, Pearson). This is the first time that
raised levels of the gold standard measure of in vivo oxidative stress
(isoprostanes) and their association with CFS symptoms have been
reported.
PMID: 16085177 [PubMed - in process]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
--------------------------------------------------------------------------------