Oxidative Stress ?

Discussion in 'Health and medical' started by Doe, Feb 21, 2004.

  1. Doe

    Doe Guest

    Arterioscler Thromb Vasc Biol. 2004 Feb 19 [Epub ahead of print] Related Articles, Links

    Is Oxidative Stress the Pathogenic Mechanism Underlying Insulin Resistance, Diabetes, and
    Cardiovascular Disease? The Common Soil Hypothesis Revisited.

    Ceriello A, Motz E.

    Department of Pathology and Medicine, Experimental and Clinical, University of Udine, Italy.

    Type 2 diabetes is a worldwide increasing disease resulting from the interaction between a subject's
    genetic makeup and lifestyle. In genetically predisposed subjects, the combination of excess caloric
    intake and reduced physical activity induces a state of insulin resistance. When beta cells are no
    longer able to compensate for insulin resistance by adequately increasing insulin production,
    impaired glucose tolerance appears, characterized by excessive postprandial hyperglycemia. Impaired
    glucose tolerance may evolve into overt diabetes. These 3 conditions, ie, insulin resistance,
    impaired glucose tolerance, and overt diabetes, are associated with an increased risk of
    cardiovascular disease. Because all these conditions are also accompanied by the presence of an
    oxidative stress, this article proposes oxidative stress as the pathogenic mechanism linking insulin
    resistance with dysfunction of both beta cells and endothelium, eventually leading to overt diabetes
    and cardiovascular disease. This hypothesis, moreover, may also contribute to explaining why
    treating cardiovascular risk with drugs, such as calcium channel blockers, ACE inhibitors, AT-1
    receptor antagonists, and statins, all compounds showing intracellular preventive antioxidant
    activity, results in the onset of new cases of diabetes possibly being reduced.

    PMID: 14976002 [PubMed - as supplied by publisher]

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  2. No Way

    No Way Guest

    doe <[email protected]> wrote in message
    news:[email protected]...
    > Arterioscler Thromb Vasc Biol. 2004 Feb 19 [Epub ahead of print] Related Articles, Links
    >
    >
    > Is Oxidative Stress the Pathogenic Mechanism Underlying Insulin
    Resistance,
    > Diabetes, and Cardiovascular Disease? The Common Soil Hypothesis
    Revisited.
    >
    > Ceriello A, Motz E.
    >
    > Department of Pathology and Medicine, Experimental and Clinical,
    University of
    > Udine, Italy.
    >
    > Type 2 diabetes is a worldwide increasing disease resulting from the interaction between a
    > subject's genetic makeup and lifestyle. In
    genetically
    > predisposed subjects, the combination of excess caloric intake and reduced physical activity
    > induces a state of insulin resistance. When beta cells
    are no
    > longer able to compensate for insulin resistance by adequately increasing insulin production,
    > impaired glucose tolerance appears, characterized by excessive postprandial hyperglycemia.
    > Impaired glucose tolerance may
    evolve
    > into overt diabetes. These 3 conditions, ie, insulin resistance, impaired glucose tolerance, and
    > overt diabetes, are associated with an increased
    risk of
    > cardiovascular disease. Because all these conditions are also accompanied
    by
    > the presence of an oxidative stress, this article proposes oxidative
    stress as
    > the pathogenic mechanism linking insulin resistance with dysfunction of
    both
    > beta cells and endothelium, eventually leading to overt diabetes and cardiovascular disease. This
    > hypothesis, moreover, may also contribute to explaining why treating cardiovascular risk with
    > drugs, such as calcium
    channel
    > blockers, ACE inhibitors, AT-1 receptor antagonists, and statins, all
    compounds
    > showing intracellular preventive antioxidant activity, results in the
    onset of
    > new cases of diabetes possibly being reduced.
    >
    > PMID: 14976002 [PubMed - as supplied by publisher]
    >
    > --------------------------------------------------------------------------
    > ------
    >
    Oxidative Stress

    http://www.immunesystemsupport.com/osicaand/chapt-42.html
     
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