Possible Cure for Leaky Gut?

Discussion in 'Food and nutrition' started by jaym1212, Mar 1, 2006.

  1. jaym1212

    jaym1212 Guest

    Recent article (http://www.ucl.ac.uk/media/library/crohn) states that
    Crohn's Disease (CD), chronic inflammation of gut lining, may be due to
    a reduced response by neutrophils (part of immune system) in keeping
    mucosal invaders (even commensal bacteria) in check.

    A cursory search for ways to increase the neutrophil's immune response
    leads me to suspect that maybe our modern diet is too clean and that
    some of us need to include more fungus in our diet! Or more
    specifically Beta-Glucans which are a component of fungus (yeast,
    mushrooms) cell walls. Any thoughts? See article below:

    Beta-Glucan Enhances Action of Immune Cells
    Medical Doctors and researchers at Brown Medical School and Rhode
    Island hospital have discovered that beta 1,3-D glucan, a natural
    compound derived from bakers yeast, binds to receptors on neutrophils,
    the most abundant type of immune cell in the body. The beta glucan
    caused the neutrophils to take a more direct path to the site of
    infection rather than the indirect route normally taken.

    Neutrophils are attracted to the site of an infection by blood proteins
    called chemoattractants and are among the first cells of the body to
    respond to a challenge due to infection or injury. Normally,
    neutrophils use such chemoattractants as interleukin-8 to travel to the
    site of infection. However, when neutrophils were treated with beta
    1,3-D glucan, the neutrophils bypassed the IL-8 and went directly to
    the source of infection. Beta 1,3-D appeared to accomplish this by
    increasing the neutrophils ability to sense complement fragments
    emanating from the site of an infection. As a result, beta glucan helps
    neutrophils locate the epicenter of the bacterial infection within
    tissue.

    This ability to make neutrophils bypass IL-8 and go directly to the
    site of infection could result in a more rapid response to infection
    and a faster microbial clearance and healing, the researchers
    theorized. But, they said, further studies are needed to confirm
    whether expediting neutrophils journey to the infection site enhances
    immunity.

    http://intelegen.com/ImmuneSystem/betaglucan_enhances_action_of_i.htm
     
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  2. montygram

    montygram Guest

    I had this problem and it almost killed me. I tried almost everything
    on the market. What I needed was more stomach acid, and those
    supplements are cheap and generic. You can also use vinegar, but then
    you don't get the pepsin enzymes that most supplements have.

    What happens is that due to the "leaky gut," food gets into the
    bloodstream and is targeted as an antigen. Over time, too much
    antigenic exposure will weaken the "immune system," shifting it from
    Th1 to Th2, as occurs in various acquired immune deficiency syndromes.
    In what might be called "classic AIDS," there is often a deadly PCP
    infection of the lungs, which is due to the shift, followed by the
    fungal overgrowth. In "leaky gut," this occurs in the GI tract. One
    should eat a little yogurt with live cultures with every meal too (make
    sure it is plain, whole milk, and preferably organic). No need for
    expensive supplements.
     
  3. jaym1212

    jaym1212 Guest

    > One should eat a little yogurt with live cultures ...

    While this is good practice for most, in my case, allergy to milk
    product is so severe that just placing it in my mouth causes my ears to
    become red in 15 minutes. I do take serveral pre and probiotics through
    out the day. But this hasn't healed the leaky gut to any discrenable
    degree.

    > What happens is that due to the "leaky gut," food gets into the
    > bloodstream and is targeted as an antigen.


    Yes, this is what seems to be happening. Currently I cannot eat protein
    sources such as dairy, eggs, meat, fish, poultry, grains, legumes, nuts
    and seeds without deterioration of various tissues through out the
    body, even if the food is soaked, sprouted, slow cooked, pressure
    cooked and then blended with multi-enzymes into a slurry. In my case,
    the least allergenic foods are vegetables and fruits. Currenlty I used
    free-form amino acids to augment protein intake.

    > I had this problem and it almost killed me.
    > I tried almost everything on the market. What I needed was more stomach acid,
    > and those supplements are cheap and generic. You can also use vinegar, but then
    > you don't get the pepsin enzymes that most supplements have.


    Per your suggestion about half a year ago, I started using
    plant-enzymes, bromelain, papain, HCl with pepsin and enteric coated
    pancreatic enzymes. I also use a quart of vinegar (with salads) during
    the course of a week.

    But none of the supplements and alternative treatments (meditation,
    yoga, exercise) seem to correct the core problem. According to the
    sited article, the root problem maybe the sluggish response of one's
    neutrophils to bacteria invading gut lining. Other than beta glucans,
    can someone recommend ways to increase neutrophil activity along gut
    lining?
     
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