Psoriasis latest

I suggest also posting to alt.support.skin-
diseases.psoriasis Or simply search the group using Google's
search engine.

In a previous article, "tonyp" <[email hidden]>
wrote: -> ->Dear sci.med[.immunology]sters, -> ->At the risk
of appearing lazy and attracting spam, does anyone have any
->recent info regarding the treatment of psoriasis?. Stuff
with coal tar and ->corticosteroids in it seems to be all I
can find. -> ->TIA -> ->-- ->Cheers, ->Tony. -> -

Quoted message said:

Instructions from a packet of chinese "Self-mucosity Mat"s

-> ->Application ->1) Attached to woody floor marble surface
or the bottom of furniture, she ->can lessen friction and
noise and defend scratch. ->2)Attached to the base of TV,
soundbox DVD, phone, computer, flatbottomed ->bottle and
cabinet and so on,she can mitigate tremble,defend
slide,decrease ->noise and prolong their uselife. ->3)She is
more suitably applied to the root of heavy that is
frequently moved -> ->Caution ->1)Be careful to peel mount
off. Don't take mat and glue apart. ->2)Avoid touching glue
cover, or glue will lose his mucosity. ->3)If there is some
displacement,she can go on using after replacement. -> -

Quoted message said:

Subject: Psoriasis latest
From: "tonyp" [email hidden]
Date: 3/20/2004 3:17 AM Mountain Standard Time
Message-id: <[email hidden]>

Dear sci.med[.immunology]sters,

At the risk of appearing lazy and attracting spam, does
anyone have any recent info regarding the treatment of
psoriasis?. Stuff with coal tar and corticosteroids in it
seems to be all I can find.

TIA

--
Cheers, Tony.

Instructions from a packet of chinese "Self-mucosity Mat"s

Application
1) Attached to woody floor marble surface or the bottom of
furniture, she can lessen friction and noise and defend
scratch.
2)Attached to the base of TV, soundbox DVD, phone,
computer, flatbottomed bottle and cabinet and so on,she
can mitigate tremble,defend slide,decrease noise and
prolong their uselife.
3)She is more suitably applied to the root of heavy that is
frequently moved

Caution
1)Be careful to peel mount off. Don't take mat and
glue apart.
2)Avoid touching glue cover, or glue will lose his
mucosity.
3)If there is some displacement,she can go on using after
replacement.

Follow up with a search of oxidative stress / antioxidants /
psoriasis should bring some results.

<<snip>> The results confirm the involvement of antioxidant
enzymes in the pathogenesis of psoriasis <<snip>>

Med Sci Monit 2002 Aug;8(8):BR338-43 Related Articles, Books

Activity of superoxide dismutase and catalase and the level
of lipid peroxidation products reactive with TBA in patients
with psoriasis.

Drewa G, Krzyzynska-Malinowska E, Wozniak A, Protas-Drozd F,
Mila-Kierzenkowska C, Rozwodowska M, Kowaliszyn B,
Czajkowski R.

Chair and Department of Biology, Ludwik Rydygier Medical
University, Bydgoszcz, Poland.

BACKGROUND: The etiology of psoriasis, one of the most
common chronic dermatoses, has not been elucidated yet.
Involvement of antioxidant enzymes is suspected. The study
aimed to determine the concentrations of lipid peroxidation
products reactive with thiobarbituric acid and antioxidant
enzymes activity. MATERIAL/METHODS: 67 patients of the Chair
and Clinic of Dermatology (22 females and 45 males) with
psoriasis vulgaris of 3 to 34 years' duration were examined.
All were treated topically with preparations for external
use. Smooth skin was treated with salicyl ointment,
cignoline and tar, while salicyl oil and betamethasone
dipropionide with salicylic acid was used on the scalp.
Lipid peroxidation products reactive with TBA, expressed as
malondialdehyde
(MDA) concentration, were determined in erythrocytes
using Buege and Aust method. Activities of
antioxidant enzymes, superoxide dismutase (SOD)
and catalase (CAT), were determined in
erythrocytes according to Misra and Fridovich, and
Beers and Sizer, respectively. RESULTS: In healthy
subjects, SOD and CAT activity was 1049.2I261.9
U/gHb and 41.4I13.7 i 104 IU/gHb, respectively,
and MDA concentration 35.8I10.5 nM/gHb. MDA
concentrations in erythrocytes of psoriatic
patients before treatment were 44% higher and SOD
and CAT activities 20% and 27% lower,
respectively, than those observed in the controls.
Topical treatment improved the patients' clinical
condition, resulting in slow increase of enzyme
activity to values comparable with controls.
CONCLUSIONS: The results confirm the involvement
of antioxidant enzymes in the pathogenesis of
psoriasis. It is, however, questionable whether
the observed abnormalities are responsible for the
onset of psoriasis, or resultant from ongoing
pathologic process.

PMID: 12165738 [PubMed - in process]

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Biological therapy for psoriasis: an overview of infliximab,
etanercept, efalizumab and alefacept.

Tutrone WD, Saini R, Weinberg JM.

St Luke's-Roosevelt Hospital Center, Department of
Dermatology, 1090 Amsterdam Avenue, Suite 11D, New York, NY
10025, USA. [email hidden]

Psoriasis is a chronic skin disorder that affects
approximately 2% of the US and European population. Over the
last several years one of the major foci in psoriasis
research has been the development of biological therapies
for this disease. The aim of these therapies is to provide
selective, immunologically directed intervention with fewer
side effects than traditional therapies. This article will
review the progress of four biological agents that are
available or under investigation for clinical use:
infliximab (Centocor Inc), etanercept (Amgen Inc/Wyeth),
efalizumab (Genentech Inc/XOMA Ltd/Serono SA) and alefacept.

Hope this helps.

Daniele Focosi