Re: cystic fibrosis

Quoted message said:

Subject: Re: cystic fibrosis
From: [email hidden]
Date: 9/1/2004 11:58 AM Mountain Daylight Time
Message-id: <[email hidden]>

A classic response, the abstract does not say what you thought it said,

"Iron and iron-regulatory cytokines may play a role in cystic fibrosis lung
disease and the increased iron content may even facilitate Pseudomonas
aeruginosa infection."

I believe it says .. elevated .. iron ..

You don't think it says elevated .. iron .. ?

That means you are stupid ..

Quoted message said:

or
more likely what you were primed to find in it.

"Iron and iron-regulatory cytokines may play a role in cystic fibrosis lung
disease and the increased iron content may even facilitate Pseudomonas
aeruginosa infection."

I believe it says .. elevated .. iron ..

You don't think it says elevated .. iron .. ?

That means you are stupid ..

Use that abstract and

Quoted message said:

explain how iron causes the disorder in question. Just don't smip a
sentence, explain it from your understanding what they are suggesting,
that last word being the central point, there is no confirmation but a
suggestion to understand. I will say no more, not wanting to spoil your
crack at explaining the content of the abstract in your own words.

"Iron and iron-regulatory cytokines may play a role in cystic fibrosis lung
disease and the increased iron content may even facilitate Pseudomonas
aeruginosa infection."

I believe it says .. elevated .. iron ..

You don't think it says elevated .. iron .. ?

That means you are stupid ..

Quoted message said:

Quoted message said:

Quoted message said:

This is a genetic disorder, even veggie alone folk get it if the genes are
there. Iron doesn't cause it.

It HAS been hypothesized to BE .. related .. TO .. genetic iron overload ..
thusly .. it 'may' .. BE .. related to iron .. as to IRON .. causing .. it

..

Quoted message said:

http://tinyurl.com/6cj2t

So unless you have a citation .. which says SPECIFICALLY it is NOT .. iron
related .. then .. S..T .. F .. U ..

Dig ..?
Understand ..?
Comprendez ..?

Quoted message said:

>Eur Respir J. 2004 Aug;24(2):286-91. Related Articles, Links
>
>
>Airway iron and iron-regulatory cytokines in cystic fibrosis.
>
>Reid DW, Lam QT, Schneider H, Walters EH.
>
>Adult Cystic Fibrosis Centre, Alfred Hospital and Monash University

Medical

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>School, Melbourne, Australia. [email hidden]
>
>Iron availability is critical to Pseudomonas aeruginosa. The current

authors

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>determined sputum iron, ferritin, microalbumin levels and total cell

counts

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>(TCC) in 19 adult patients with cystic fibrosis (CF) during an acute
>exacerbation and repeated analyses following a median of 12 days

antibiotic

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>treatment. The current authors also determined sputum interleukin

(IL)-1beta

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>and tumour necrosis factor (TNF)-alpha levels because of their putative

role

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in
>intracellular iron homeostasis. Additional data were obtained from 17

stable

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CF
>patients, eight patients with stable chronic obstructive pulmonary disease
>(COPD) and six normal subjects. Overall, sputum iron, ferritin,
microalbumin,
>IL-1beta and TNF-alpha concentrations and TCCs were significantly elevated
in
>the CF patients compared to those with COPD and normal controls. Sputum
>ferritin levels were significantly elevated in acute versus stable CF
patients
>and there was a trend for sputum TCC to be higher, but all other
inflammatory
>indices were similar. In the CF patients, sputum iron was positively and
>strongly related to IL-1beta, TNF-alpha, ferritin and microalbumin levels,
but
>negatively related to forced expiratory volume in one second % predicted.

In

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>those acute patients who clinically improved with antibiotics (n=14),

there

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>were significant decreases in sputum TCC, iron, ferritin and IL-1beta
content,
>but not TNF-alpha or albumin levels. However, changes in sputum TNF-alpha

in

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>acute patients were still closely related to changes in iron, ferritin and
>albumin content, and changes in IL-1beta were related to changes in sputum
>ferritin content. Iron and iron-regulatory cytokines may play a role in
cystic
>fibrosis lung disease and the increased iron content may even facilitate
>Pseudomonas aeruginosa infection.
>
>PMID: 15332399 [PubMed - in process]
>
>--------------------------------------------------------------------------
>------
>
>Who loves ya.
>Tom

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