Re: Protein / Fats/ Carbs relative to bodyweight



E

elzinator

Guest
DZ wrote:
> JMW <[email protected]> wrote:
> > Ign0ramus18142 wrote:
> >>>> Actually endurance athletes can get away with a little less

protein
> >>>> although in the scheme of things it is not all that much less

really.
> >>>
> >>> actually, endurance athletes can thrive on significantly less

protein

"Thrive"? That does not imply that 'significantly less" protein is
optimal for performance. Although conclusions in research papers are
discordant, and may always be, the data suggests otherwise. Even the
Kenyan runners take in more protein than many realize. The question is
less how much, but may be more what proteins are being synthesized and
degraded and at what rate. Not all dietary protein is destined for
myofibrillar proteins. Another important point that is only now given
consideration is timing of protein intake; it may be more important
than overal total intake.

> >>Time to look up actual studies guys...

> >
> > The "real issue" is several issues. First, it's not an issue of
> > "athletes don't need more protein than ..." but rather, an issue of
> > "the average diet contains significantly less protein than ..."
> > Another significant issue is *when* the amino acids are available;
> > studies suggest that a high level of circulating essential amino

acids
> > immediately after resistance training, and over the next few hours,
> > are very beneficial for muscles protein synthesis. Inherent in

that
> > issue is how fast ingested protein is broken down and absorbed into
> > circulating EAAs. Also, highly glycemic carbohydrates prompt

insulin
> > release, which is helpful in preventing muscle protein breakdown

and
> > for increasing the expression of amino acid transporters in muscle
> > cells.


One reason 'fast' available proteins is so popular is not only because
of the rate that AAs are added to the total amino acid pool, but that
several of the EAAs induce an insulin response, with or without dietary
carbs. Ideally, or optimally, the goal is to 'top off' the AA pool
prior to exercise (endurance and resistance), then assuring a steady
state AA pool for the next 36-48 hours post-exercise (depending on
intensity and volume of both E and RT). Merits exist for dietary carbs
during and post-exercise, too(mediates hormonal response, total protein
catabolism, etc).

> Just to add to the "several issues" issue. Studies look at "optimal"
> in the sense of optimizing relatively short (many years) term

progress
> (e.g. strength, endurance, speed) in sports. But a substantial
> proportion of people have different goals, and many who don't have
> competition related goals have already reached fitness levels far
> above the average.
>
> Consider claims like these (PMID: 12699727) "restriction of foods

with
> a high glycemic index ... would avoid or delay many diseases of aging
> and might result in life extension".


The key words in the above excerpt are 'would' and 'might'. Diet
intervention to increase life span and avoid age-related diseases is
relative to overall lifestyle.

> Then the above "highly glycemic carbohydrates prompt insulin release,
> which is helpful in preventing muscle protein breakdown" is no longer
> optimal when sport and health related goals are considered
> simultaneously.


Again, relative to dose and duration. Your comment does not encompass
overall diet and/or lifestyle, thus your assumption is simplistic.
Intake of high glycemic carbs post-exercise has little relevance to
lifespan and disease prevention unless overall diet and lifestyle are
considered. Many athletes consume HGI carbs only post-exercise, when
the muscle tissue is most receptive for total body glucose clearance.
Otherwise, they eat low-GI carbs. This will most likely not affect
total health-related goals while benefiting sports performance. In
fact, if this reduces muscle loss, then the net benefit is positive,
not negative.

> Looked another way, one can define fitness oriented success by LBM,
> strength, and endurance measured many decades from starting the
> training program. Then (relatively) quick fixes like satiating body
> with nutrients become less and less appealing. For example, in (PMID:
> 14734642) they determined that old calorie restricted mice had higher
> LBM, even though they had less muscle while young.


As a biologist and statistician you should know better. As was
mentioned at last week's conference and elsewhere in the literature,
the calorie restriction animal models have very limited relevance to
humans. It has not been demonstrated that the same applies to human
beings. Even the KLOTHO gene is species specific.

> What we need is a new journal, a hybrid between "Medicine and Science
> in Sports and Exercise" and "Experimental Gerontology".


If you look close enough, there are articles/studies associated with
exercise and sports medicine published in several of the genrontology
journals. Here's one place to start: J Gerontol Biol Sci Med Sci.

> > The studies are abundant. A recent review by Kevin Tipton and

Robert
> > Wolfe covers much of this in detail:
> >
> > Tipton KD, Wolfe RR. Protein and amino acids for athletes. J Sports
> > Sci. 2004 Jan;22(1):65-79.


Yeah, did you read it yet? :)
BTW, be sure to read other authors before you form conclusions. You
will find that the issue of protein and carb intake around exercise and
training is hotly debated. A few authors don't agree with Tipton, on
both sides of the 'fence', and for valid reasons. Other authors to
read: Ivy, Lemmon, Tanapolsky, Burns and one in Oz-land that I can't
recall the name of right now.
 
elzinator <[email protected]> wrote:
> DZ wrote:
>> Just to add to the "several issues" issue. Studies look at "optimal"
>> in the sense of optimizing relatively short (many years) term progress
>> (e.g. strength, endurance, speed) in sports. But a substantial
>> proportion of people have different goals, and many who don't have
>> competition related goals have already reached fitness levels far
>> above the average.
>>
>> Consider claims like these (PMID: 12699727) "restriction of foods with
>> a high glycemic index ... would avoid or delay many diseases of aging
>> and might result in life extension".

>
> The key words in the above excerpt are 'would' and 'might'. Diet
> intervention to increase life span and avoid age-related diseases is
> relative to overall lifestyle.
>
>> Then the above "highly glycemic carbohydrates prompt insulin release,
>> which is helpful in preventing muscle protein breakdown" is no longer
>> optimal when sport and health related goals are considered
>> simultaneously.

>
> Again, relative to dose and duration. Your comment does not encompass
> overall diet and/or lifestyle, thus your assumption is simplistic.
> Intake of high glycemic carbs post-exercise has little relevance to
> lifespan and disease prevention unless overall diet and lifestyle are
> considered. Many athletes consume HGI carbs only post-exercise, when
> the muscle tissue is most receptive for total body glucose clearance.
> Otherwise, they eat low-GI carbs. This will most likely not affect
> total health-related goals while benefiting sports performance. In
> fact, if this reduces muscle loss, then the net benefit is positive,
> not negative.


"Only post-exercise" HGI carbs is a good point. However, I wouldn't
dispute the positive net benefit (wrt muscle loss) of the
post-exercise HGI carbs addition in the first place. Addition of
powerful anabolic substances would have the same short term net
benefit, but I wouldn't take them even if they were legal.

>> Looked another way, one can define fitness oriented success by LBM,
>> strength, and endurance measured many decades from starting the
>> training program. Then (relatively) quick fixes like satiating body
>> with nutrients become less and less appealing. For example, in (PMID:
>> 14734642) they determined that old calorie restricted mice had higher
>> LBM, even though they had less muscle while young.

>
> As a biologist and statistician you should know better.


An advantage of being both is that I don't *have* to know better. I
just put on the other hat. Seriously, I don't claim (or need to have)
more insight than other participants of this discussion.

> As was mentioned at last week's conference and elsewhere in the
> literature, the calorie restriction animal models have very limited
> relevance to humans. It has not been demonstrated that the same
> applies to human beings. Even the KLOTHO gene is species specific.


I don't agree with the "limited relevance" part. My very general
understanding is that

* Species-specific differences in life span are genetically
controlled.

* There is no programmed life span, but there is a point where the
protection mechanisms (warranty) stop and "let us go". The "let us go
part" is to an extent concerted. Struck by this thought, Henry Ford
was spotted pillaging through garbage on junk yards to find
functioning parts surviving past vehicle lifes, with the goal to
identify those and reduce their quality.

* These mechanisms are result of selection by population mechanisms
similar to those controlling recombination rates.

* They are as old and conserved as Kreb's cycle although
species-specific some degree.

* The picture is fuzzy but, sirtuins, forkheads, systemic igf
regulation is involved and CR happens to positively affect these in
studied animals; monkeys results underway. There is abundance of
forkheads and muscleheads in uk.rec.bodybuilding.

* By the time the mechanism is well understood the CR (shot-gun
approach) will become a non-issue because they'll know which genes to
target and how, by drug intervention. Only wealthy will be able to
afford it though which will emerge as a foil to deteriorating effects
of reverse Darwinism (prop the humor antenna).

DZ
 
DZ wrote:
> elzinator <[email protected]> wrote:


> > As was mentioned at last week's conference and elsewhere in the
> > literature, the calorie restriction animal models have very limited
> > relevance to humans. It has not been demonstrated that the same
> > applies to human beings. Even the KLOTHO gene is species specific.

>
> I don't agree with the "limited relevance" part. My very general
> understanding is that


I do agree with myself.

> * Species-specific differences in life span are genetically
> controlled.


Regardless, genetics is only an recipe for opportunity. Gene expression
is a product of interacting environment and genes.

> * There is no programmed life span, but there is a point where the
> protection mechanisms (warranty) stop and "let us go". The "let us go
> part" is to an extent concerted. Struck by this thought, Henry Ford
> was spotted pillaging through garbage on junk yards to find
> functioning parts surviving past vehicle lifes, with the goal to
> identify those and reduce their quality.


Is the effect of caloric restriction on life span a universal
phenomenon with a comparable response for different species, or does
the effect depend on the life history of the organism?

"We exploit an evolutionary argument to show that the response of life
span to CR is determined by demographic entropy, a measure of the
variability in the age at which individuals in a population reproduce
and die. We predict that in high entropy species, which consist of
organisms described by late sexual maturity, broad reproductive span
and small litter size, the increase in life span under caloric
restriction will be negligible; whereas, in low entropy species,
consisting of organisms defined by early sexual maturity, narrow
reproductive span and large litter size, the increase in life span
under caloric restriction will be significant."
(Demetrius L. Caloric restriction, metabolic rate, and entropy. J
Gerontol A Biol Sci Med Sci. 2004; 59(9):B902-15.)

> * These mechanisms are result of selection by population mechanisms
> similar to those controlling recombination rates.
>
> * They are as old and conserved as Kreb's cycle although
> species-specific some degree.


See above.

> * The picture is fuzzy but, sirtuins, forkheads, systemic igf
> regulation is involved and CR happens to positively affect these in
> studied animals; monkeys results underway. There is abundance of
> forkheads and muscleheads in uk.rec.bodybuilding.


Then there is the UnSIRtainty principle (Davenport, RJ. Calorie
restriction Un-SIR-tainty. Sci Aging Knowledge Environ. 2004 May
12;2004(19):nf48)

> * By the time the mechanism is well understood the CR (shot-gun
> approach) will become a non-issue because they'll know which genes to
> target and how, by drug intervention. Only wealthy will be able to
> afford it though which will emerge as a foil to deteriorating effects
> of reverse Darwinism (prop the humor antenna).


Yes, I see your humor antenna is operating well lately :)

For your pleasure, you may find the following article interesting:
Weinert BT, Timiras PS. Invited review: Theories of aging. J Appl
Physiol. 2003;95(4):1706-16.

And for a discussion of longevity models:
Longo VD, Finch CE. Evolutionary medicine: from dwarf model systems to
healthy centenarians? Science. 2003; 28;299(5611):1342-6. (a special
issue on aging)
and
Heilbronn LK, Ravussin E. Calorie restriction and aging: review of the
literature and implications for studies in humans. Am J Clin Nutr.
2003;78(3):361-9.

BTW, the FIRKO mouse model (in which the insulin receptor is spatially
knocked out in adipose tissue) ate more (~120%), had lower fat mass and
total body weight and lived longer than the wild type. Certainly not an
example of caloric restriction and extended life span.
 
"elzinator" <[email protected]> wrote in message
news:[email protected]...
> DZ wrote:
>> JMW <[email protected]> wrote:
>> > Ign0ramus18142 wrote:
>> >>>> Actually endurance athletes can get away with a little less

> protein
>> >>>> although in the scheme of things it is not all that much less

> really.
>> >>>
>> >>> actually, endurance athletes can thrive on significantly less

> protein
>
> "Thrive"? That does not imply that 'significantly less" protein is
> optimal for performance. Although conclusions in research papers are
> discordant, and may always be, the data suggests otherwise. Even the
> Kenyan runners take in more protein than many realize. The question is
> less how much, but may be more what proteins are being synthesized and
> degraded and at what rate. Not all dietary protein is destined for
> myofibrillar proteins. Another important point that is only now given
> consideration is timing of protein intake; it may be more important
> than overal total intake.
>
>> >>Time to look up actual studies guys...
>> >
>> > The "real issue" is several issues. First, it's not an issue of
>> > "athletes don't need more protein than ..." but rather, an issue of
>> > "the average diet contains significantly less protein than ..."
>> > Another significant issue is *when* the amino acids are available;
>> > studies suggest that a high level of circulating essential amino

> acids
>> > immediately after resistance training, and over the next few hours,
>> > are very beneficial for muscles protein synthesis. Inherent in

> that
>> > issue is how fast ingested protein is broken down and absorbed into
>> > circulating EAAs. Also, highly glycemic carbohydrates prompt

> insulin
>> > release, which is helpful in preventing muscle protein breakdown

> and
>> > for increasing the expression of amino acid transporters in muscle
>> > cells.

>
> One reason 'fast' available proteins is so popular is not only because
> of the rate that AAs are added to the total amino acid pool, but that
> several of the EAAs induce an insulin response, with or without dietary
> carbs. Ideally, or optimally, the goal is to 'top off' the AA pool
> prior to exercise (endurance and resistance), then assuring a steady
> state AA pool for the next 36-48 hours post-exercise (depending on
> intensity and volume of both E and RT). Merits exist for dietary carbs
> during and post-exercise, too(mediates hormonal response, total protein
> catabolism, etc).
>
>> Just to add to the "several issues" issue. Studies look at "optimal"
>> in the sense of optimizing relatively short (many years) term

> progress
>> (e.g. strength, endurance, speed) in sports. But a substantial
>> proportion of people have different goals, and many who don't have
>> competition related goals have already reached fitness levels far
>> above the average.
>>
>> Consider claims like these (PMID: 12699727) "restriction of foods

> with
>> a high glycemic index ... would avoid or delay many diseases of aging
>> and might result in life extension".

>
> The key words in the above excerpt are 'would' and 'might'. Diet
> intervention to increase life span and avoid age-related diseases is
> relative to overall lifestyle.
>
>> Then the above "highly glycemic carbohydrates prompt insulin release,
>> which is helpful in preventing muscle protein breakdown" is no longer
>> optimal when sport and health related goals are considered
>> simultaneously.

>
> Again, relative to dose and duration. Your comment does not encompass
> overall diet and/or lifestyle, thus your assumption is simplistic.
> Intake of high glycemic carbs post-exercise has little relevance to
> lifespan and disease prevention unless overall diet and lifestyle are
> considered. Many athletes consume HGI carbs only post-exercise, when
> the muscle tissue is most receptive for total body glucose clearance.
> Otherwise, they eat low-GI carbs. This will most likely not affect
> total health-related goals while benefiting sports performance. In
> fact, if this reduces muscle loss, then the net benefit is positive,
> not negative.
>
>> Looked another way, one can define fitness oriented success by LBM,
>> strength, and endurance measured many decades from starting the
>> training program. Then (relatively) quick fixes like satiating body
>> with nutrients become less and less appealing. For example, in (PMID:
>> 14734642) they determined that old calorie restricted mice had higher
>> LBM, even though they had less muscle while young.

>
> As a biologist and statistician you should know better. As was
> mentioned at last week's conference and elsewhere in the literature,
> the calorie restriction animal models have very limited relevance to
> humans. It has not been demonstrated that the same applies to human
> beings. Even the KLOTHO gene is species specific.
>
>> What we need is a new journal, a hybrid between "Medicine and Science
>> in Sports and Exercise" and "Experimental Gerontology".

>
> If you look close enough, there are articles/studies associated with
> exercise and sports medicine published in several of the genrontology
> journals. Here's one place to start: J Gerontol Biol Sci Med Sci.
>
>> > The studies are abundant. A recent review by Kevin Tipton and

> Robert
>> > Wolfe covers much of this in detail:
>> >
>> > Tipton KD, Wolfe RR. Protein and amino acids for athletes. J Sports
>> > Sci. 2004 Jan;22(1):65-79.

>
> Yeah, did you read it yet? :)
> BTW, be sure to read other authors before you form conclusions. You
> will find that the issue of protein and carb intake around exercise and
> training is hotly debated. A few authors don't agree with Tipton, on
> both sides of the 'fence', and for valid reasons. Other authors to
> read: Ivy, Lemmon, Tanapolsky, Burns and one in Oz-land that I can't
> recall the name of right now.
>


Louise Burke???
 
Sam wrote:
> "elzinator" <[email protected]> wrote in message
> > BTW, be sure to read other authors before you form conclusions. You
> > will find that the issue of protein and carb intake around exercise

and
> > training is hotly debated. A few authors don't agree with Tipton,

on
> > both sides of the 'fence', and for valid reasons. Other authors to
> > read: Ivy, Lemmon, Tanapolsky, Burns and one in Oz-land that I

can't
> > recall the name of right now.
> >

>
> Louise Burke???


Yes, Thanks (brain fart :)
 

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