A
Alf Christophersen
Guest
On 27 Feb 2005 11:59:48 -0800, "[email protected]"
<[email protected]> wrote:
>formation and protected LLC-PK(1) cells. These studies suggest that
>taurine may exhibit cytoprotective effects against the oxidation
>products of catecholamines by acting as a scavenger for free radicals
>and cytotoxic quinones.
A possible mechanism is that taurine in itself has little
antioxidative activity, but that it form mixed chelates with iron or
copper together with phosphate groups, thus blocking the metal ion in
participating into redox cycling processes.
And since taurine long time has been known to react directly with MDA
and all other aldehydes, the observed decrease in free MDA production
may just be a side effect of that reaction, that the researcher did
not measure amount of taurine-MDA complex formed. Maybe MDA production
brutto is not changed at all. No one knows since no one ever measured
this in biological systems, only in lab where MDA and taurine are left
at 37 deg C to react.(and do then form adducts)
<[email protected]> wrote:
>formation and protected LLC-PK(1) cells. These studies suggest that
>taurine may exhibit cytoprotective effects against the oxidation
>products of catecholamines by acting as a scavenger for free radicals
>and cytotoxic quinones.
A possible mechanism is that taurine in itself has little
antioxidative activity, but that it form mixed chelates with iron or
copper together with phosphate groups, thus blocking the metal ion in
participating into redox cycling processes.
And since taurine long time has been known to react directly with MDA
and all other aldehydes, the observed decrease in free MDA production
may just be a side effect of that reaction, that the researcher did
not measure amount of taurine-MDA complex formed. Maybe MDA production
brutto is not changed at all. No one knows since no one ever measured
this in biological systems, only in lab where MDA and taurine are left
at 37 deg C to react.(and do then form adducts)