On my training wheels i have a 12-25 rear cassette, and it works well with my 39 & 52 chain rings. I have just bought some race wheels and got a 12-23 cassette with them and i find it a real pain, due to the the fact that "i am always changing between the two front chanrings to get the best gear". I just wish i could get up to that 19 tooth gear but the Shimano manuels say not to use the large chainring with either of the TWO largest rear gears and the small chainring with the TWO small rear gears as this puts too much twist on the chain. I don't know how true this is. It is a ULTEGRA cassette, is it possible to pull it apart and change some of the larger gears?