Resveratrol / oxidation



http://www.ag.uiuc.edu/~ffh/resvera.html

Cell Mol Biol Lett. 2004;9(4A):577-87. Related Articles, Links


Resveratrol protects against peroxynitrite-induced thiol oxidation in
blood platelets.

Olas B, Nowak P, Wachowicz B.

Department of General Biochemistry, University of Lodz Banacha 12/16,
90-237 Lodz, Poland.

The peroxynitrite anion (ONOO(-)) is a reactive species produced in the
reaction between the superoxide anion (O(2)((-)) and nitric oxide
((()NO). ONOO(-)is involved in several pathological conditions such as
inflammation, arteriosclerosis, and neurodegenerative and
cardiovascular disorders. Our earlier results showed that
ONOO(-)inhibits different steps of blood platelet activation and causes
the depletion of platelet thiols. In this study, we investigated the
effects of resveratrol (3, 4('), 5-trihydroxystilbene) and other
antioxidants (uric acid and deferoxamine (DFO)) on the level of low
molecular thiols such as glutathione, cysteine and cysteinylglycine (in
reduced and oxidized form) in blood platelets treated with ONOO(-). Our
results showed that ONOO(-)(100 muM, 2 min) induces changes in these
thiols (measured by HPLC method); these changes are diminished in the
presence of resveratrol. Preincubation of human platelets with
resveratrol at a concentration of 100 muM (30 min) has a protective
effect against the oxidation of platelet thiols induced by ONOO(-)or
its intermediate. The other tested antioxidants also have a protectory
action. In conclusion, we suggest that the resveratrol present in the
human diet may partially protect -SH groups from oxidation and may be
responsible for redox regulation and control in platelets.

PMID: 15647782 [PubMed - in process]

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