My advice to any one who is concerned about there PSA is to pay the "big buck" and get a saddle that has a midline split. PSA is just an average number not to many urologist use PSA as a definitive answer to prostate problems, its the getting up at night, frequent urination, etc... I would recommend a baseline exam before the cycling season then after the season get another exam. There is not much information on saddles and prostate cancer, I genetically inherited my prostate problem (BHP). Actually I more worried about my type II diabetes then prostate CA.