Thanks This is what I was looking for
))
BL 1204 <
[email protected]> wrote in message
news:20040208135243.19973.00001432@mb-
m17.aol.com...
> type in "second hand smoke" at
>
>
http://www.ncbi.nlm.nih.gov/PubMed/
>
> There are more like these"
>
> Nicotine Tob Res. 2003 Dec;5(6):943-6.
>
> Secondhand smoke and earaches in adolescents: the Florida Youth Cohort
Study.
>
> Lee DJ, Gaynor JJ, Trapido E.
>
> University of Miami, Tobacco Research and Evaluation Coordinating Center, Sylvester Comprehensive
> Cancer Center, Miami, FL 33101, USA.
[email protected]
>
> The association between second-hand smoke exposure and adolescent middle
ear
> problems has not been examined. A random sample stratified by region was
drawn
> from a list that included approximately 40% of all Florida households with children in grades 4-7.
> A total of 785 Florida adolescents initially
enrolled
> in the 4th-7th grade participated in three telephone interviews conducted
over
> a 24-month period. At the round 3 interview, 10.3% of participants
reported one
> or more earaches within the previous 30 days. Several second-hand smoke exposure questions asked
> at each of the three interviews were associated
with
> the number of reported earaches. Stepwise polytomous logistic regression indicated that parental
> smoking inside the home reported at the round 3 interview was associated with the number of
> reported earaches (OR=3.11,
95%
> CI=1.70-5.66). Once this variable was selected, none of the other
second-hand
> smoke exposure variables offered additional predictive value (p>.1). None
of
> the non-second-hand smoke exposure variables, including the participant's
own
> history of tobacco use, had any association with the reporting of earaches
> (p>.05). Second-hand smoke exposure is associated with self-reported
earaches
> in adolescents. These findings should be replicated in a study in which clinical measures of
> middle ear function are performed.
>
> PMID: 14668078
>
> Clin Dev Immunol. 2003 Mar;10(1):35-42.
>
> Second-hand smoke increases bronchial hyperreactivity and eosinophilia in
a
> murine model of allergic aspergillosis.
>
> Seymour BW, Schelegle ES, Pinkerton KE, Friebertshauser KE, Peake JL,
Kurupd
> VP, Coffman RL, Gershwin LJ.
>
> Department of Pathology, Microbiology and Immunology, 1126 Haring Hall,
School
> of Veterinary Medicine, University of California, One Shields Avenue,
Davis, CA
> 95616, USA.
>
> Involuntary inhalation of tobacco smoke has been shown to aggravate the allergic response.
> Antibodies to fungal antigens such as Aspergillus
fumigatus
> (Af) cause an allergic lung disease in humans. This study was carried out
to
> determine the effect of environmental tobacco smoke (ETS) on a murine
model of
> allergic bronchopulmonary aspergillosis (ABPA). BALB/c mice were exposed
to
> aged and diluted sidestream cigarette smoke to simulate 'second-hand
smoke'.
> The concentration was consistent with that achieved in enclosed public
areas or
> households where multiple people smoke. During exposure, mice were
sensitized
> to Af antigen intranasally. Mice that were sensitized to Af antigen and
exposed
> to ETS developed significantly greater airway hyperreactivity than did
mice
> similarly sensitized to Af but housed in ambient air. The effective concentration of aerosolized
> acetylcholine needed to double pulmonary flow resistance was significantly lower in Af + ETS mice
> compared to the Af +
AIR
> mice. Immunological data that supports this exacerbation of airway hyperresponsiveness being
> mediated by an enhanced type 1 hypersensitivity response include: eosinophilia in peripheral blood
> and lung sections. All
Af
> sensitized mice produced elevated levels of IL4, IL5 and IL10 but no
IFN-gamma
> indicating a polarized Th2 response. Thus, ETS can cause exacerbation of
asthma
> in ABPA as demonstrated by functional airway hyperresponsiveness and
elevated
> levels of blood eosinophilia.
>
> PMID: 14575156 BL
>
> "As the waves pass the rock, their shape is changed. There is a hologram
of
> the rock within the wave that comes forward and crashes on the beach, then there's a reflected
> wave back." Ralph Abraham
>
> "I'd like to learn to windsurf." BL
