Significant reductions in CHD risk form plant foods

Discussion in 'Food and nutrition' started by George Cherry, Aug 16, 2005.

  1. 1: Curr Atheroscler Rep. 2004 Nov;6(6):492-8. Related Articles, Links

    A dietary portfolio: maximal reduction of low-density lipoprotein
    cholesterol with diet.

    Kendall CW, Jenkins DJ.

    Department of Nutritional Sciences, Faculty of Medicine, University of
    Toronto, 150 College Street, Toronto, ON M5S 3E2, Canada.
    [email protected]

    Over the past two decades, cholesterol-lowering drugs have proven to be
    effective and have been found to significantly reduce the risk of coronary
    heart disease (CHD). However, diet and lifestyle factors are still
    recognized as the first line of intervention for CHD risk reduction by the
    National Cholesterol Education Program and the American Heart Association,
    which now advocate use of viscous fibers and plant sterols, and soy protein
    and nuts, respectively. In a series of metabolically controlled studies, we
    have combined these four cholesterol-lowering dietary components in the same
    diet (ie, a dietary portfolio of cholesterol-lowering foods) in an attempt
    to maximize low-density lipoprotein cholesterol reduction. We have found
    that the portfolio diet reduced low-density lipoprotein cholesterol by
    approximately 30% and produced clinically significant reductions in CHD
    risk. These reductions were the same as found with a starting dose of a
    first-generation statin drug.

    Publication Types:
    a.. Review
    b.. Review, Tutorial

    PMID: 15485596 [PubMed - indexed for MEDLINE]