Significant reductions in CHD risk form plant foods



G

George Cherry

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1: Curr Atheroscler Rep. 2004 Nov;6(6):492-8. Related Articles, Links


A dietary portfolio: maximal reduction of low-density lipoprotein
cholesterol with diet.

Kendall CW, Jenkins DJ.

Department of Nutritional Sciences, Faculty of Medicine, University of
Toronto, 150 College Street, Toronto, ON M5S 3E2, Canada.
[email protected]

Over the past two decades, cholesterol-lowering drugs have proven to be
effective and have been found to significantly reduce the risk of coronary
heart disease (CHD). However, diet and lifestyle factors are still
recognized as the first line of intervention for CHD risk reduction by the
National Cholesterol Education Program and the American Heart Association,
which now advocate use of viscous fibers and plant sterols, and soy protein
and nuts, respectively. In a series of metabolically controlled studies, we
have combined these four cholesterol-lowering dietary components in the same
diet (ie, a dietary portfolio of cholesterol-lowering foods) in an attempt
to maximize low-density lipoprotein cholesterol reduction. We have found
that the portfolio diet reduced low-density lipoprotein cholesterol by
approximately 30% and produced clinically significant reductions in CHD
risk. These reductions were the same as found with a starting dose of a
first-generation statin drug.

Publication Types:
a.. Review
b.. Review, Tutorial

PMID: 15485596 [PubMed - indexed for MEDLINE]