A
Archimedes Plut
Guest
Cover letter to the 3 diseases of Alzheimers, Parkinsons and Prion for
future
editing and revising to keep these two files in somewhat order:
I am massively revising my website of
www.iw.net/~a_plutonium because it is written in a
textbook fashion that it requires massive editing and
deleting and adding onto about every 5 years. I have
neglected this website for about 10 years and so I have
a big job ahead of
me.My other website of www.archimedesplutonium.com needs no
periodic editing because it is structured as a archive
that I merely collect the posts I post and enter or dump
it into the website. Archiving does not require editing
because it wants to save everything whether correct or
riddled with mistakes.
Files 150 and 151 deal with Alzheimers Parkinsons and
Prion disease. I was fortunate to have a running
dialogue and conversation with at least 3 scientists et
al from Berkeley and Cambridge Univ about these
diseases starting with the year 1997 and specifically
these dates:
Oct-Nov 1997 Dec 1998 Feb-Mar 1999 Jan 2004 so anyone
interested in that long history can view it at
www.archimedesplutonium.com website under those dates.
I must have had over 2,000 posts to the internet in
conversations with 3 or more scientists about these 3
diseases. And my old practice of filling File150 and
File151 with many of those past posts is just not
practical when I have to revise and edit so often. That
practice must cease because my archived website handles
all of those posts and no need to repeat those posts in
this textbook website where I want to achieve
understanding and clarity, not archivity.
So that means I have to toss out old posts from this
website and to attempt to keep it current and clear
and short.
Let me just remark on the history of Alzheimers,
Parkinsons, and Prion. I dived into these 3 diseases
back in October of 1997 noting the analogy similarity
of a ant disease in the tropics where a fungus infects
an ant's brain and kills the ant. I could not escape
the notice of a analogy between fungus ant disease and
Prion disease. My search for what causes prion disease
then migrated theory-wise to thinking that Prion
disease is the analogy to sickle cell anemia disease
only with a deformed brain protein instead of deformed
red blood cells. Theory migrated into many other
theories and hypothesis but then recently is news not
of Prion disease with metal-ions from phosmet and magnetic-
manganese but news from Alzheimers from a PBS TV show
in that the plaque buildup (much like prion buildup)
is caused by a rogue scissors that wrongly snips the
APP protein into 2 segments wherein the one segment
ends up being toxic and the start of the buildup of
Alzheimers plaques.
So, is there a similar scissors mechanism or scissors-
like mechanism that causes Prion disease?
So I left the discussion of Alzheimers, Parkinsons,
Prion in January of 2004 with the open issue of a
Scissors mechanism for Alzheimers and whether
Parkinsons and Prion also have a scissors mechanism and
whether magnetic-manganese is the metal-ion culprit
that causes Prion disease and whether Parkinsons and
Alzheimers also have a metal-ion facilitator culprit
such as perhaps aluminum or other metal-ions.
One of the issues I stressed and harped and harped on
from 1997 to present day is that the Nobel prize to
Prusiner for his Prion theory was a prize that was way
way too premature and huge mistake. To have given the
Nobel to Prusiner was so premature, that the Nobel
should have given a prize to any lead researcher of
Alzheimers circa 1995 to 1997 and to have given a prize
to any lead researcher for Parkinsons disease circa 1995-
1997 because in the 1990s it was widely recognized that
both Alzheimers and Parkinsons are unsolved, likewise
it is easy to see that Prion was also unsolved and that
the Prusiner award was so big of a mistake and that the
science behind it was utterly lacking and it was pushed
and pushed due to the Mad-Cow outbreak in England.
Science recognition should never be held hostage to
epidemic events in the world for that is making science
a passing fad or fashion whereas the awarding should be
for thorough understanding. The reason the Nobel
Committee never awarded Alzheimers or Parkinsons from
1990-2003 was because the mechanism for Alzheimers and
Parkinsons are still not understood even as of March
2004 but it is fair to say that the understanding of
Alzheimers is even more advanced than the understanding
of Prion disease. Prion is not understand even to this
very day, yet the Nobel Committee blustered and rammed
ahead giving a prize out for Prion disease when it
never should have. The Nobel to Prusiner is one of the
worst Nobel awards ever given because it causes the
scientists in that field to ever have to go back and
say "well the Prusiner model is wrong and just ignore
it". The Nobel Committee in giving Prusiner the award
were more rambunctious and impetuous than Mr. Bush
wanting to invade Iraq in 2003. In fact, it can be
argued that
mf.Bush had more grounds to invade Iraq than the Nobel
Committee had grounds to award Mr. Prusiner on the
science of Prion disease. And it is ironic that Mr. Blix
is from Sweden where the Nobel Committee is and that Mr.
Blix is laying it straight as far as the groundless and
baseless claims of Weapons of Mass Destruction. So, if
Mr. Blix had chaired the Nobel Committee in the 1990s, he
may well have averted another large mistake by ignoring
the sirens call to award Prusiner for his model.
One other item I want to mention for Files 150 and 151
is that in that history of 1997 on Prion disease, is
that I attacked the Prusiner Model on two grounds and
it is these two grounds which convinced me back in 1997
that the Prusiner Model is a complete fake.
(1) Thermodynamically it is impossible for a bad-prion-
molecule to convert a good-prion-molecule into an
identical copy. The energy equation just does not
give enough energy for a similar protein to alter a
different protein into a identical copy. Just not
enough energy for the interaction. On the other
hand, a DNA molecule or RNA molecule possess enough
energy dynamics to cause other molecules to convert
in an interaction.
(2) If prion proteins really did what the Prusiner
Model says then the lowest form of life is not the
cell or DNA or RNA but proteins like prion-proteins
because replication or reproduction is the main
distinguishing characteristic of life. And the
Prusiner Model is that a protein thence becomes the
lowest form of life and makes the cell and DNA as
excess baggage. And if that were true, then we
should see in the world around us not just a few
protein molecules that have a Prusiner-behaviour
but many molecules that have a Prusiner method of
replicating.
On those two ground above convinced me that the
Prusiner Model was a fake and that it is only a matter
of time before the true mechanism of how Prion disease
and how Parkinsons and Alzheimers work.
Also I need to note that I suspect that Prion,
Parkinsons and Alzheimers are different but that they
are very much alike in several similarities. So that a
mechanism of how each works may have a family
resemblance. Such that if metal-ions plays a key role
in Prion disease it is likely that metal-ions plays a
role in Parkinsons and Alzheimers and likewise for the
scissors mechanism in Alzheimers probably has a
scissors mechanism to be found in Parkinsons (perhaps
even Huntington) and Prion.
I believe these 3 diseases are related and have family
resemblances more than they are dissimilar.
Archimedes Plutonium whole entire Universe is just
one big atom where dots of the electron-dot-cloud
are galaxies
(www.iw.net/~a_plutonium) website of the science of AP
under revision what used to be my old science website
www.newphys.se/elektromagnum/physics/LudwigPlutonium
from years 1993 to 2004
future
editing and revising to keep these two files in somewhat order:
I am massively revising my website of
www.iw.net/~a_plutonium because it is written in a
textbook fashion that it requires massive editing and
deleting and adding onto about every 5 years. I have
neglected this website for about 10 years and so I have
a big job ahead of
me.My other website of www.archimedesplutonium.com needs no
periodic editing because it is structured as a archive
that I merely collect the posts I post and enter or dump
it into the website. Archiving does not require editing
because it wants to save everything whether correct or
riddled with mistakes.
Files 150 and 151 deal with Alzheimers Parkinsons and
Prion disease. I was fortunate to have a running
dialogue and conversation with at least 3 scientists et
al from Berkeley and Cambridge Univ about these
diseases starting with the year 1997 and specifically
these dates:
Oct-Nov 1997 Dec 1998 Feb-Mar 1999 Jan 2004 so anyone
interested in that long history can view it at
www.archimedesplutonium.com website under those dates.
I must have had over 2,000 posts to the internet in
conversations with 3 or more scientists about these 3
diseases. And my old practice of filling File150 and
File151 with many of those past posts is just not
practical when I have to revise and edit so often. That
practice must cease because my archived website handles
all of those posts and no need to repeat those posts in
this textbook website where I want to achieve
understanding and clarity, not archivity.
So that means I have to toss out old posts from this
website and to attempt to keep it current and clear
and short.
Let me just remark on the history of Alzheimers,
Parkinsons, and Prion. I dived into these 3 diseases
back in October of 1997 noting the analogy similarity
of a ant disease in the tropics where a fungus infects
an ant's brain and kills the ant. I could not escape
the notice of a analogy between fungus ant disease and
Prion disease. My search for what causes prion disease
then migrated theory-wise to thinking that Prion
disease is the analogy to sickle cell anemia disease
only with a deformed brain protein instead of deformed
red blood cells. Theory migrated into many other
theories and hypothesis but then recently is news not
of Prion disease with metal-ions from phosmet and magnetic-
manganese but news from Alzheimers from a PBS TV show
in that the plaque buildup (much like prion buildup)
is caused by a rogue scissors that wrongly snips the
APP protein into 2 segments wherein the one segment
ends up being toxic and the start of the buildup of
Alzheimers plaques.
So, is there a similar scissors mechanism or scissors-
like mechanism that causes Prion disease?
So I left the discussion of Alzheimers, Parkinsons,
Prion in January of 2004 with the open issue of a
Scissors mechanism for Alzheimers and whether
Parkinsons and Prion also have a scissors mechanism and
whether magnetic-manganese is the metal-ion culprit
that causes Prion disease and whether Parkinsons and
Alzheimers also have a metal-ion facilitator culprit
such as perhaps aluminum or other metal-ions.
One of the issues I stressed and harped and harped on
from 1997 to present day is that the Nobel prize to
Prusiner for his Prion theory was a prize that was way
way too premature and huge mistake. To have given the
Nobel to Prusiner was so premature, that the Nobel
should have given a prize to any lead researcher of
Alzheimers circa 1995 to 1997 and to have given a prize
to any lead researcher for Parkinsons disease circa 1995-
1997 because in the 1990s it was widely recognized that
both Alzheimers and Parkinsons are unsolved, likewise
it is easy to see that Prion was also unsolved and that
the Prusiner award was so big of a mistake and that the
science behind it was utterly lacking and it was pushed
and pushed due to the Mad-Cow outbreak in England.
Science recognition should never be held hostage to
epidemic events in the world for that is making science
a passing fad or fashion whereas the awarding should be
for thorough understanding. The reason the Nobel
Committee never awarded Alzheimers or Parkinsons from
1990-2003 was because the mechanism for Alzheimers and
Parkinsons are still not understood even as of March
2004 but it is fair to say that the understanding of
Alzheimers is even more advanced than the understanding
of Prion disease. Prion is not understand even to this
very day, yet the Nobel Committee blustered and rammed
ahead giving a prize out for Prion disease when it
never should have. The Nobel to Prusiner is one of the
worst Nobel awards ever given because it causes the
scientists in that field to ever have to go back and
say "well the Prusiner model is wrong and just ignore
it". The Nobel Committee in giving Prusiner the award
were more rambunctious and impetuous than Mr. Bush
wanting to invade Iraq in 2003. In fact, it can be
argued that
mf.Bush had more grounds to invade Iraq than the Nobel
Committee had grounds to award Mr. Prusiner on the
science of Prion disease. And it is ironic that Mr. Blix
is from Sweden where the Nobel Committee is and that Mr.
Blix is laying it straight as far as the groundless and
baseless claims of Weapons of Mass Destruction. So, if
Mr. Blix had chaired the Nobel Committee in the 1990s, he
may well have averted another large mistake by ignoring
the sirens call to award Prusiner for his model.
One other item I want to mention for Files 150 and 151
is that in that history of 1997 on Prion disease, is
that I attacked the Prusiner Model on two grounds and
it is these two grounds which convinced me back in 1997
that the Prusiner Model is a complete fake.
(1) Thermodynamically it is impossible for a bad-prion-
molecule to convert a good-prion-molecule into an
identical copy. The energy equation just does not
give enough energy for a similar protein to alter a
different protein into a identical copy. Just not
enough energy for the interaction. On the other
hand, a DNA molecule or RNA molecule possess enough
energy dynamics to cause other molecules to convert
in an interaction.
(2) If prion proteins really did what the Prusiner
Model says then the lowest form of life is not the
cell or DNA or RNA but proteins like prion-proteins
because replication or reproduction is the main
distinguishing characteristic of life. And the
Prusiner Model is that a protein thence becomes the
lowest form of life and makes the cell and DNA as
excess baggage. And if that were true, then we
should see in the world around us not just a few
protein molecules that have a Prusiner-behaviour
but many molecules that have a Prusiner method of
replicating.
On those two ground above convinced me that the
Prusiner Model was a fake and that it is only a matter
of time before the true mechanism of how Prion disease
and how Parkinsons and Alzheimers work.
Also I need to note that I suspect that Prion,
Parkinsons and Alzheimers are different but that they
are very much alike in several similarities. So that a
mechanism of how each works may have a family
resemblance. Such that if metal-ions plays a key role
in Prion disease it is likely that metal-ions plays a
role in Parkinsons and Alzheimers and likewise for the
scissors mechanism in Alzheimers probably has a
scissors mechanism to be found in Parkinsons (perhaps
even Huntington) and Prion.
I believe these 3 diseases are related and have family
resemblances more than they are dissimilar.
Archimedes Plutonium whole entire Universe is just
one big atom where dots of the electron-dot-cloud
are galaxies
(www.iw.net/~a_plutonium) website of the science of AP
under revision what used to be my old science website
www.newphys.se/elektromagnum/physics/LudwigPlutonium
from years 1993 to 2004