Statin / antioxidant

Discussion in 'Health and medical' started by Doe, Jun 7, 2004.

  1. Doe

    Doe Guest

    <<snip>> Recent data suggest that these compounds, in
    addition to their lipid-lowering ability, can also reduce
    the production of reactive oxygen species and increase
    the resistance of LDL to oxidation. It may be that the
    ability of statins to limit the oxidation of LDL
    contributes to their effectiveness at preventing
    atherosclerotic disease <<snip>>

    Atherosclerosis. 2004 Mar;173(1):1-12. Related
    Articles, Links

    Statins in atherosclerosis: lipid-lowering agents with
    antioxidant capabilities.

    Rosenson RS.

    Preventive Cardiology Center, Northwestern University, The
    Feinberg School of Medicine, 201 E. Huron Street, Galter
    Pavilion, Suite 11-120, Chicago, IL 60611, USA.

    Low-density lipoprotein (LDL) cholesterol is an established
    risk factor for coronary heart disease (CHD). In the
    presence of oxidative stress LDL particles can become
    oxidized to form a lipoprotein species that is particularly
    atherogenic. Indeed, oxidized LDL (oxLDL) is pro-
    inflammatory, it can cause endothelial dysfunction and it
    readily accumulates within the arterial wall. Several
    factors may influence the susceptibility of LDL to
    oxidation, including its size and composition, and the
    presence of endogenous antioxidant compounds, such as alpha-
    tocopherol. Individuals with type 2 diabetes or the
    metabolic syndrome have high levels of oxidative stress and
    consequently are at an increased risk for cardiovascular
    events. Reducing oxidative stress has been proposed as a
    potential approach to prevent CHD and antioxidant vitamins
    have been employed with encouraging results in experimental
    models of atherosclerosis. However, clinical trials have not
    demonstrated consistent beneficial effects of antioxidants
    on cardiovascular outcomes. Statins (3-hydroxy-3-
    methylglutaryl coenzyme A reductase inhibitors) are the first-
    line choice for lowering total and LDL cholesterol levels
    and they have been proven to reduce the risk of CHD. Recent
    data suggest that these compounds, in addition to their lipid-
    lowering ability, can also reduce the production of reactive
    oxygen species and increase the resistance of LDL to
    oxidation. It may be that the ability of statins to limit
    the oxidation of LDL contributes to their effectiveness at
    preventing atherosclerotic disease.

    PMID: 15177118 [PubMed - as supplied by publisher]

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