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Pol J Pharmacol. 2004 Jan-Feb;56(1):85-96. Related Articles, Links
Attenuation of oxidative stress-induced changes in
thalassemic erythrocytes by vitamin E.
Das N, Chowdhury TD, Chattopadhyay A, Datta AG.
Department of Life Science and Biotechnology, Jadavpur
University, Kolkata - 700 032, India. [email protected];
[email protected]
The oxidative stress status of the transfusion-dependant Ebeta-
and beta-thalassemia patients were studied before and after
treatment with vitamin E for a period of four weeks. The
level of cellular vitamin antioxidants viz. ascorbic acid
and vitamin E in the thalassemia patients were found to be
considerably lower compared to normal subjects. The
activities of enzymatic antioxidants viz. catalase,
glutathione peroxidase and glutathione reductase were found
to be drastically reduced in untreated Ebeta- and beta-
thalassemic patients when compared to normal subjects.
However, the activity of superoxide dis-mutase was found to
be increased in both types of untreated thalassemic patients
when compared to normal individuals. An increase in
superoxide dismutase and a decrease in catalase activity
reflects the presence of a severe oxidative stress situation
in the erythrocytes of the untreated transfusion dependant
Ebeta- and beta-thalassemia patients. Changes in erythrocyte
membrane protein pattern in untreated Ebeta- and beta-
thalassemia patients when compared to normal erythrocyte
further confirm the presence of continued oxidative stress
in the ailing thalassemic erythrocytes. All these changes in
the antioxidant status as well as the changes in the
erythrocyte membrane proteins are ameliorated to
considerable extent when the transfusion-dependent Ebeta-
and beta-thalassemia patients were treated with vitamin E at
a dose of 10
mg/kg/day for a period of four weeks. The patients during
the treatment period did not exhibit any side effects and
gained in body weight indicating a healthy status. The
present study reveals that the lipophilic antioxidant
vitamin E could be useful in the management of transfusion-
dependant Ebeta- and beta-thalassemia patients.
PMID: 15047982 [PubMed - in process]
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Attenuation of oxidative stress-induced changes in
thalassemic erythrocytes by vitamin E.
Das N, Chowdhury TD, Chattopadhyay A, Datta AG.
Department of Life Science and Biotechnology, Jadavpur
University, Kolkata - 700 032, India. [email protected];
[email protected]
The oxidative stress status of the transfusion-dependant Ebeta-
and beta-thalassemia patients were studied before and after
treatment with vitamin E for a period of four weeks. The
level of cellular vitamin antioxidants viz. ascorbic acid
and vitamin E in the thalassemia patients were found to be
considerably lower compared to normal subjects. The
activities of enzymatic antioxidants viz. catalase,
glutathione peroxidase and glutathione reductase were found
to be drastically reduced in untreated Ebeta- and beta-
thalassemic patients when compared to normal subjects.
However, the activity of superoxide dis-mutase was found to
be increased in both types of untreated thalassemic patients
when compared to normal individuals. An increase in
superoxide dismutase and a decrease in catalase activity
reflects the presence of a severe oxidative stress situation
in the erythrocytes of the untreated transfusion dependant
Ebeta- and beta-thalassemia patients. Changes in erythrocyte
membrane protein pattern in untreated Ebeta- and beta-
thalassemia patients when compared to normal erythrocyte
further confirm the presence of continued oxidative stress
in the ailing thalassemic erythrocytes. All these changes in
the antioxidant status as well as the changes in the
erythrocyte membrane proteins are ameliorated to
considerable extent when the transfusion-dependent Ebeta-
and beta-thalassemia patients were treated with vitamin E at
a dose of 10
mg/kg/day for a period of four weeks. The patients during
the treatment period did not exhibit any side effects and
gained in body weight indicating a healthy status. The
present study reveals that the lipophilic antioxidant
vitamin E could be useful in the management of transfusion-
dependant Ebeta- and beta-thalassemia patients.
PMID: 15047982 [PubMed - in process]
------------------------------------------------------------
--------------
------
Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking