Thalassemia / tocopherol / vitamin E

Discussion in 'Health and medical' started by Doe, Mar 30, 2004.

  1. Doe

    Doe Guest

    Pol J Pharmacol. 2004 Jan-Feb;56(1):85-96. Related Articles, Links

    Attenuation of oxidative stress-induced changes in
    thalassemic erythrocytes by vitamin E.

    Das N, Chowdhury TD, Chattopadhyay A, Datta AG.

    Department of Life Science and Biotechnology, Jadavpur
    University, Kolkata - 700 032, India. [email protected];
    [email protected]

    The oxidative stress status of the transfusion-dependant Ebeta-
    and beta-thalassemia patients were studied before and after
    treatment with vitamin E for a period of four weeks. The
    level of cellular vitamin antioxidants viz. ascorbic acid
    and vitamin E in the thalassemia patients were found to be
    considerably lower compared to normal subjects. The
    activities of enzymatic antioxidants viz. catalase,
    glutathione peroxidase and glutathione reductase were found
    to be drastically reduced in untreated Ebeta- and beta-
    thalassemic patients when compared to normal subjects.
    However, the activity of superoxide dis-mutase was found to
    be increased in both types of untreated thalassemic patients
    when compared to normal individuals. An increase in
    superoxide dismutase and a decrease in catalase activity
    reflects the presence of a severe oxidative stress situation
    in the erythrocytes of the untreated transfusion dependant
    Ebeta- and beta-thalassemia patients. Changes in erythrocyte
    membrane protein pattern in untreated Ebeta- and beta-
    thalassemia patients when compared to normal erythrocyte
    further confirm the presence of continued oxidative stress
    in the ailing thalassemic erythrocytes. All these changes in
    the antioxidant status as well as the changes in the
    erythrocyte membrane proteins are ameliorated to
    considerable extent when the transfusion-dependent Ebeta-
    and beta-thalassemia patients were treated with vitamin E at
    a dose of 10
    mg/kg/day for a period of four weeks. The patients during
    the treatment period did not exhibit any side effects and
    gained in body weight indicating a healthy status. The
    present study reveals that the lipophilic antioxidant
    vitamin E could be useful in the management of transfusion-
    dependant Ebeta- and beta-thalassemia patients.

    PMID: 15047982 [PubMed - in process]

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