Orv Hetil. 2003 Jun 8;144(23):1121-8. [The pathogenesis of atherosclerosis]
[Article in Hungarian]
Jakab L.
Semmelweis Egyetem, Altalanos Orvostudomanyi Kar, III. sz. Belgyogyaszati Klinika, Budapest.
The article dealing with the pathogenesis of atherosclerosis, summarizes the knowledge, which relies
on the latest investigative results, and which is in connection with the starting of atherosclerosis
and with the chronic type inflammation ongoing in the arterial vessel wall, having individual
characteristics. Then the general features of the inflammatory response of the organism, the
emerging infections, just as that of the autoimmune phenomena are touched upon. The importance of
the contribution to the pathogenetic chain of the lipoproteins, the connective tissue matrix
proteoglycans and glycosaminoglycans is summed up in distinct chapters. The distinguished
significance of the attachment between the proteoglycans and lipoproteins, oxydized lipopoteins is
particularly underlined. It is established that the chronic nature inflammatory process, possessing
individual characteristics, has essential role in the starting, development and in the entire course
of the pathological process. The impacts of infections, and that of the possible immunodeficiencies
are uncertain. In the author's opinion the definition of atherosclerosis syndrome might be as
follows. The point is a non specific chronic inflammatory response of the organism in the form of a
specific vasculitis, which constitutes ground to the development of the atherosclerotic process.
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