Thinking outside the box

Quoted message said:

Subject: Thinking outside the box
From: "Evon" [email hidden]
Date: 11/19/2003 12:06 PM Mountain Standard Time
Message-id: <[email hidden]>

Aug. 25, 2003 Reuters News published a article about the (IDF) International Diabetes Federation
conference in Paris. The outcome of this conference was that diabetes is about to become a world
wide epidemic greater than AIDS! By 2025 world wide spending on diabetes will be between 213 -396
BILLION US dollars. So far no real know cause or cure for it.

I was wondering, could there be a, as of yet unknown or unidentified bug that maybe causing
diabetes?

Anything is possible ..

Quoted message said:

I know this sounds off the wall - but current thinking isn't helping us.

Actually current thinking seems to be gaining ground ..

IE: link made between MINOR elevations of iron in the body and diabetes.

Since 80% of those with diabetes are type 2 .. then the finding of reduction by 50% in all the study
participants would mean .. millions .. of .. people .. ?

annals.org869 bOpen ↗

Iron has only recently begun to take off so to speak in the research department.

They seem to think it is coming from a high iron diet.
medscape.com439591Open ↗

Diabetes 2002 Aug;51(8):2348-54

Cross-talk between iron metabolism and diabetes.

Fernandez-Real JM, Lopez-Bermejo A, Ricart W.

Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta,
Girona, Spain. [email hidden]

Emerging scientific evidence has disclosed unsuspected influences between iron metabolism and type 2
diabetes. The relationship is bi-directional--iron affects glucose metabolism, and glucose
metabolism impinges on several iron metabolic pathways. Oxidative stress and inflammatory cytokines
influence these relationships, amplifying and potentiating the initiated events. The clinical impact
of these interactions depends on both the genetic predisposition and the time frame in which this
network of closely related signals acts. In recent years, increased iron stores have been found to
predict the development of type 2 diabetes while iron depletion was protective. Iron-induced damage
might also modulate the development of chronic diabetes complications. Iron depletion has been
demonstrated to be beneficial in coronary artery responses, endothelial dysfunction, insulin
secretion, insulin action, and metabolic control in type 2 diabetes. Here, we show that iron
modulates insulin action in healthy individuals and in patients with type 2 diabetes. The extent of
this influence should be tested in large-scale clinical trials, searching for the usefulness and cost-
effectiveness of therapeutic measures that decrease iron toxicity. The study of individual
susceptibility and of the mechanisms that influence tissue iron deposition and damage are proposed
to be valuable in anticipating and treating diabetes complications.

Publication Types: Review Review, Tutorial

PMID: 12145144

----------------------------------------------------

Quoted message said:

What are your thoughts. Remember, I'm >only the messenger.

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have you forgotten about that fact that obesity has been on the rise??

dave

Evon said:

Aug. 25, 2003 Reuters News published a article about the (IDF) International Diabetes Federation
conference in Paris. The outcome of this conference was that diabetes is about to become a world
wide epidemic greater than AIDS! By 2025 world wide spending on diabetes will be between 213 -396
BILLION US dollars. So far no real know cause or cure for it.

I was wondering, could there be a, as of yet unknown or unidentified bug that maybe causing
diabetes? I know this sounds off the wall - but current thinking isn't helping us. What are your
thoughts. Remember, I'm only the messenger.

Well, a lot of popular misinformation
1) obesity, as you know it, is NOT on the rise - average weights are up a few pounds, but the
definition of "obesity" has been dropped

2) Diabetes is probably NOT on the rise. We now TEST for diabetes - we didn't use to. If you have
ONE fbg of 126, you are considered diabetois.

When I was diagnosed, about 18 years ago, the drill was,
3) I had symptoms - in my case, I was dehydrating.
4) I had a FBG test, if it was under 200, I would not have been considered diabetic.
5) I had another FBG once a year, untill I had three readings over 200 - THREE YEARS OVER 200 - in
my case, the readings were 450, because they didn'et even start testing till I was in trouble.
If, at any time, I had a reading UNDER 200, they would have waithed another three years.
6) THEN, they would schedule a GTT, in a few months, after the GTT was done, and the results cane
back, I would be told, I was "possibly" diabetic, and should avoid sugar!

so, I was over 400 for FOUR YEARS before I was diagnosed. By todays standards, I probably would have
been diagnosed 20 years earlier.

Problems with diabetic complecations are DROPPING, despite the increase in diagnosed diabetics -
THAT is because today we are DIAGNOSED - before, we wern't.

Bay Area Dave said:

have you forgotten about that fact that obesity has been on the rise??

dave

Evon said:

Aug. 25, 2003 Reuters News published a article about the (IDF) International Diabetes Federation
conference in Paris. The outcome of this conference was that diabetes is about to become a world
wide epidemic greater than AIDS! By 2025 world wide spending on diabetes will be between 213 -396
BILLION US dollars. So far no real know cause or cure for it.

I was wondering, could there be a, as of yet unknown or unidentified bug that maybe causing
diabetes? I know this sounds off the wall - but current thinking isn't helping us. What are your
thoughts. Remember, I'm only the messenger.