Unless you want it just purely for the heck of it, I think it has been well proven by the likes of Giant, Trek and mannnny other manufacturers that a standard frame size can easily be adapted using the many modern components that are available. There are now stems, cranks, bars, etc. to suit all comers, and unless you have a _truly_ unusual physique, you should be able to set up a stock frame to perfection.
Now, some East End wideboy is gonna chime in, well, yeah sure you betcha but this is all wrong because your weight distribution won't be spot on unless you get a custom. And I'll bat that one out of the air by noting that we all ride our bikes in so many different positions that the weight moves all over the place anyway. No one can seriously argue that moving the front wheel up or back one cm relative to the rider is going to make any serious difference in handling in all of these positions.
I say, starting at the BB spindle, get your saddle where it should be and get your bars where they should be, try for a 12-13cm stem, depending on bar reach etc., put on good components, and unless you're a top 1 or 2 you can quickly forget about the bike as the critical link in the chain.