If your tube is actually leaking it's not likely to improve while out on the road. Are you sure you're not just seeing the pressure drop over time typical of a latex tube? If you really have a leaky valve stem then I'd change out the tire before your race or at the very least slime the tube to minimize further losses. But riding on a known leak sounds like setting yourself up for trouble out on the course.
And what the heck are you doing running 150 psi for a 5 hour road race? On anything but the smoothest surfaces (like really fast wood tracks) Crr typically increases with very high pressures. It depends on your weight and the road surface, but typical charts for rider plus bike and kit at 80 kg show lowest Crr around 110 to 120 psi on real world roads. Sure a very hard tire bouncing around on all the road irregularities feels really fast, but that don't make it so....
-Dave