Unbound / free iron and diabetic infection

Discussion in 'Food and nutrition' started by Doe, Mar 7, 2004.

  1. Doe

    Doe Guest

    http://www.anaesthetist.com/icu/infect/fungi/mucor.htm

    Acta Pathol Jpn. 1986 Oct;36(10):1507-12. Related
    Articles, Links

    Mucormycosis in diabetic ketoacidosis. Role of unbound iron
    binding capacity of transferrin.

    Abe F, Shibuya H, Tateyama M, Ommura Y, Azumi N, Kimura K.

    Increased susceptibility to Rhizopus oryzae in diabetes was
    investigated using mice in which diabetic ketoacidosis was
    experimentally induced. All of the diabetic mice which had
    developed ketoacidosis died within four days after
    inoculation of R. oryzae and their serum UIBCs (Unbound iron
    binding capacity) were significantly lower than those of the
    normal control mice. This study suggested that the decreased
    serum UIBC produced by diabetic ketoacidosis enhances the
    growth of R. oryzae in vivo.

    PMID: 3099540 [PubMed - indexed for MEDLINE]

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