Unbound / free iron and diabetic infection

[Doe]

http://www.anaesthetist.com/icu/infect/fungi/mucor.htm

Acta Pathol Jpn. 1986 Oct;36(10):1507-12. Related
Articles, Links

Mucormycosis in diabetic ketoacidosis. Role of unbound iron
binding capacity of transferrin.

Abe F, Shibuya H, Tateyama M, Ommura Y, Azumi N, Kimura K.

Increased susceptibility to Rhizopus oryzae in diabetes was
investigated using mice in which diabetic ketoacidosis was
experimentally induced. All of the diabetic mice which had
developed ketoacidosis died within four days after
inoculation of R. oryzae and their serum UIBCs (Unbound iron
binding capacity) were significantly lower than those of the
normal control mice. This study suggested that the decreased
serum UIBC produced by diabetic ketoacidosis enhances the
growth of R. oryzae in vivo.

PMID: 3099540 [PubMed - indexed for MEDLINE]

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