General fitness, health and nutrition · Public discussion

Vitamin E / fracture repair

Started by doe · · Last activity · 3 posts · 297 views

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General fitness, health and nutrition
Published
9 October 2004
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11 October 2004
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  1. J Int Med Res. 2004 Sep-Oct;32(5):507-12. Related Articles, Links

    Promotion of fracture healing by vitamin E in rats.

    Turk C, Halici M, Guney A, Akgun H, Sahin V, Muhtaroglu S.

    Department of Orthopaedics and Traumatology, Medical Faculty, Erciyes
    University, Kayseri, Turkey.

    We investigated the effects of the antioxidant alphae-tocopherol on early- and
    late-phase fracture healing in a rat model. Sixty male Sprague-Dawley rats were
    randomized into two groups. The right tibia of each rat was fractured manually
    under anaesthesia, and fracture sites fixed with intramedullary Kirschner
    wires. The alpha-tocopherol group received 20 mg/kg alpha-tocopherol
    intraperitoneally; the control group received intraperitoneal saline
    injections. Ten rats from each group were sacrificed on day 15, day 45 and day
    60. In the alpha-tocopherol group, malondialdehyde concentrations, a measure of
    lipid peroxidation associated with oxygen free radicals, were significantly
    decreased on day 15 and day 45 compared with the control group, but had
    regained the 15-day value on day 60. On histopathological and radiological
    assessment, fracture healing on day 60 was significantly more advanced in the
    alpha-tocopherol group. We conclude that alpha-tocopherol has a positive effect
    on both early and late-phase fracture healing, and may be beneficial in
    clinical fracture

    PMID: 15458283 [PubMed - in process]

    --------------------------------------------------------------------------
    ------

    Who loves ya.
    Tom
    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

  2. I will remember this if I ever have to treat a rat with a broken leg.

    Jeff

    "doe" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:

    J Int Med Res. 2004 Sep-Oct;32(5):507-12. Related Articles, Links

    Promotion of fracture healing by vitamin E in rats.

    Turk C, Halici M, Guney A, Akgun H, Sahin V, Muhtaroglu S.

    Department of Orthopaedics and Traumatology, Medical Faculty, Erciyes
    University, Kayseri, Turkey.

    We investigated the effects of the antioxidant alphae-tocopherol on early-


    and

    Quoted message said:

    late-phase fracture healing in a rat model. Sixty male Sprague-Dawley rats


    were

    Quoted message said:

    randomized into two groups. The right tibia of each rat was fractured


    manually

    Quoted message said:

    under anaesthesia, and fracture sites fixed with intramedullary Kirschner
    wires. The alpha-tocopherol group received 20 mg/kg alpha-tocopherol
    intraperitoneally; the control group received intraperitoneal saline
    injections. Ten rats from each group were sacrificed on day 15, day 45 and


    day

    Quoted message said:

    60. In the alpha-tocopherol group, malondialdehyde concentrations, a


    measure of

    Quoted message said:

    lipid peroxidation associated with oxygen free radicals, were


    significantly

    Quoted message said:

    decreased on day 15 and day 45 compared with the control group, but had
    regained the 15-day value on day 60. On histopathological and radiological
    assessment, fracture healing on day 60 was significantly more advanced in


    the

    Quoted message said:

    alpha-tocopherol group. We conclude that alpha-tocopherol has a positive


    effect

    Quoted message said:

    on both early and late-phase fracture healing, and may be beneficial in
    clinical fracture

    PMID: 15458283 [PubMed - in process]

    --------------------------------------------------------------------------
    ------

    Who loves ya.
    Tom
    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING


    http://pages.ivillage.com/ironjustice/deadpeoplewalking

    Quoted message said:
  3. "Jeff" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:

    I will remember this if I ever have to treat a rat with a


    broken leg.

    Quoted message said:


    Jeff

    one of our friends age 63 on another NG... was riding his
    motorcycle in arizona doing about 60 mph when a deer jumped
    onto his chest and took him off the bike, he hit a rock wall
    and broke 127 bones in his body.... his face was mush, broken
    bones pushed back behind his ears. both feet shattered, jaw is
    now a piece of titanium... both legs, both hips, colar bone,
    ribs one arm... his ass was broken... one leg had to be
    amputated below the knee, he had massive systemic
    infections... and his heart stopped a few times and he had to
    have stints and two pace makers... the bruising to his heart
    was so bad that one doctor said it was amost totally dead
    tissue and he would need a heart transplant...

    he was wearing the best in protective gear too..full face
    helmut, racing boots, full padded leathers, and gloves etc.

    4 of his close friends on bikes and one sherrif were right
    behind him when it happened...he got the best of the best
    evacuation and medical care.

    a few hundred people on the NG.. sport bikers mostly...prayed
    for him.. some sent him kind thoughts of warm [censored]..whatever
    they could come up with,..bob, thats our friend who was mushed
    into hamburger finally came to... and said he could feel the
    prayers... Bob is a salty old [censored] so that was
    surprising....so we know that helped (pets in hosptials help
    a lot too but we couldnt get one into the ICU)

    and he was nuts for awhile planning to escape from the
    hospital while still in traction... his head was swollen up
    like a beach ball on steroids... he looked real bad for a long
    time

    but he made it. the accident was 4 months ago, he got out of
    the hospital last month.. he is at home doing rehab...he has
    two bikes, one an 186 mph Suzuki crotch rocket (now a nessy
    looking ball of aluminum and plastic, covered with deer hair
    and guts)...the other a haul ass Truimph triple that he is
    polishing up for his triumpant return.

    I will tell him to take vitamins...

    we have congratulated him on quiting smoking... we all lied
    to him in unison about that...we told him he quite years
    ago... the man can't remember a damn thing about any of
    that...so now he is a non smoker..

    Phil Scott

    Quoted message said:


    "doe" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:

    J Int Med Res. 2004 Sep-Oct;32(5):507-12. Related


    Articles, Links

    Quoted message said:
    Quoted message said:

    Promotion of fracture healing by vitamin E in rats.

    Turk C, Halici M, Guney A, Akgun H, Sahin V, Muhtaroglu S.

    Department of Orthopaedics and Traumatology, Medical


    Faculty, Erciyes

    Quoted message said:
    Quoted message said:

    University, Kayseri, Turkey.

    We investigated the effects of the antioxidant


    alphae-tocopherol on early-

    Quoted message said:

    and

    Quoted message said:

    late-phase fracture healing in a rat model. Sixty male


    Sprague-Dawley rats

    Quoted message said:

    were

    Quoted message said:

    randomized into two groups. The right tibia of each rat


    was fractured

    Quoted message said:

    manually

    Quoted message said:

    under anaesthesia, and fracture sites fixed with


    intramedullary Kirschner

    Quoted message said:
    Quoted message said:

    wires. The alpha-tocopherol group received 20 mg/kg


    alpha-tocopherol

    Quoted message said:
    Quoted message said:

    intraperitoneally; the control group received


    intraperitoneal saline

    Quoted message said:
    Quoted message said:

    injections. Ten rats from each group were sacrificed on


    day 15, day 45 and

    Quoted message said:

    day

    Quoted message said:

    60. In the alpha-tocopherol group, malondialdehyde


    concentrations, a

    Quoted message said:

    measure of

    Quoted message said:

    lipid peroxidation associated with oxygen free radicals,


    were

    Quoted message said:

    significantly

    Quoted message said:

    decreased on day 15 and day 45 compared with the control


    group, but had

    Quoted message said:
    Quoted message said:

    regained the 15-day value on day 60. On histopathological


    and radiological

    Quoted message said:
    Quoted message said:

    assessment, fracture healing on day 60 was significantly


    more advanced in

    Quoted message said:

    the

    Quoted message said:

    alpha-tocopherol group. We conclude that alpha-tocopherol


    has a positive

    Quoted message said:

    effect

    Quoted message said:

    on both early and late-phase fracture healing, and may be


    beneficial in

    Quoted message said:
    Quoted message said:

    clinical fracture

    PMID: 15458283 [PubMed - in process]

    ------------------------------------------------------------


    --------------

    Quoted message said:
    Quoted message said:

    ------

    Who loves ya.
    Tom
    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore!


    http://pages.ivillage.com/ironjustice/manisaherbivore

    Quoted message said:
    Quoted message said:

    DEAD PEOPLE WALKING


    http://pages.ivillage.com/ironjustice/deadpeoplewalking

    Quoted message said:

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