snood said:
All the HGH talk is stupid. HGH helps you stay lean not much more.
Now I don't think you are a doctor that specializes in doping, and I'm not, but this statement just doesn't stand up to reason.
1. The drug has been around for decades, and its use is widespread amongst athletes. Chinese Swimmer Yuan Yuan was busted in 1998 at Sydney Airport customs trying to smuggle 13 vials of the stuff (enough to supply the whole team at the world championships about to start in Perth). If what you say is true, then the whole athletic world and related doctors are numbskulls that would benefit greatly from your knowledge.
2. WADA have absolutely no upside in creating a red-herring out of HGH. This revelation is only embarrassing to them, and only increases the public perception that their role is relatively impotent in respect to prevention of doping.
Here is some research on the topic (I only have pasted copies of the abstracts):
The Growth Hormone/Insulin-Like Growth Factor-I Axis in Exercise and Sport
James Gibney, Marie-Louise Healy and Peter H. Sönksen
[size=-1]Department of Endocrinology and Diabetes (J.G.), Adelaide and Meath Hospital, Tallaght, Dublin 24, Ireland; Department of Endocrinology and Diabetes (M.-L.H.), St. James’s Hospital, Dublin 8, Ireland; and Endocrinology and Metabolism Subdivision (P.H.S.), Developmental Origins of Adult Health and Disease Division, School of Medicine, University of Southampton, Southampton, United Kingdom [/size]
[size=-1]Correspondence: Address all correspondence and requests for reprints to: Peter Sönksen, East Wing Preshaw House, Preshaw, Upham, Hants SO32 1HP, United Kingdom. E-mail:
[email protected] [/size]
The syndrome of adult GH deficiency and the effects of GH replacement therapy provide a useful model with which to study the effects of the GH/IGF-I axis on exercise physiology. Measures of exercise performance including maximal oxygen uptake and ventilatory threshold are impaired in adult GH deficiency and improved by GH replacement, probably through some combination of increased oxygen delivery to exercising muscle, increased fatty acid availability with glycogen sparing, increased muscle strength, improved body composition, and improved thermoregulation. In normal subjects, in addition to the long-term effects of GH/IGF-I status, there is evidence that the acute GH response to exercise is important in regulating substrate metabolism after exercise. Administration of supraphysiological doses of GH to athletes increases fatty acid availability and reduces oxidative protein loss, particularly during exercise, and increases lean body mass. Despite a lack of evidence that these metabolic effects translate to improved performance, GH abuse by athletes is widespread. Tests to detect GH abuse have been developed based on measurement in serum of 1) indirect markers of GH action, and 2) the relative proportions of the two major naturally occurring isoforms (20 and 22kDa) of GH. There is evidence that exercise performance and strength are improved by administration of GH and testosterone in combination to elderly subjects. The potential benefits of GH in these situations must be weighed against potential adverse effects.
And also:
Effects of High-Dose Growth Hormone on Glucose and Glycerol Metabolism at Rest and during Exercise in Endurance-Trained Athletes
M. L. Healy, J. Gibney, C. Pentecost, P. Croos, D. L. Russell-Jones, P. H. Sönksen and A. M. Umpleby
Department of Diabetes and Endocrinology, Guy’s, King’s and St. Thomas’ School of Medicine, St. Thomas Hospital, London SE1 7EH, United Kingdom
[size=-1]Address all correspondence and requests for reprints to: Dr. James Gibney, Department of Endocrinology, Adelaide & Meath Hospitals, incorporating the National Children’s Hospital, Tallaght, Dublin 24, Ireland. E-mail:
[email protected] .[/size]
Context: Recombinant human-GH (r-hGH), in supraphysiological doses, is self-administered by athletes in the belief that it is performance enhancing.
Objective: The objective of this study was to determine whether r-hGH alters whole-body glucose and glycerol metabolism in endurance-trained athletes at rest and during and after exercise.
Design: This was a 4-wk double-blind placebo-controlled trial.
Setting: This study was conducted at St. Thomas Hospital (London, UK).
Participants: Twelve endurance-trained male athletes were recruited and randomized to r-hGH (0.2 U/kg·d) (n = 6) or identical placebo (n = 6) for 4 wk. One (placebo group) withdrew after randomization.
Intervention: Intervention was conducted by randomization to r-hGH (0.2 U/kg·d) or identical placebo for 4 wk.
Main Outcome Measures: Whole-body rates of appearance (Ra) of glucose and glycerol (an index of lipolysis) and rate of disappearance of glucose were measured using infusions of [size=-2]D[/size]-[6–6-2H2]glucose and 2H5-glycerol.
Results: Plasma levels of glycerol and free fatty acids and glycerol Ra at rest and during and after exercise increased during r-hGH treatment (
P < 0.05
vs. placebo). Glucose Ra and glucose rate of disappearance were greater after exercise during r-hGH treatment (
P < 0.05
vs. placebo). Resting energy expenditure and fat oxidation were greater under resting conditions during r-hGH treatment (
P < 0.05
vs. placebo).
Conclusions: r-hGH in endurance-trained athletes increased lipolysis and fatty acid availability at rest and during and after exercise. r-hGH increased glucose production and uptake rates after exercise. The relevance of these effects for athletic performance is not known.