Occup Environ Med. 2004 Jan;61(1):82-5. Links
Total body iron overload in welder's siderosis.
Doherty MJ, Healy M, Richardson SG, Fisher NC.
Department of Respiratory Medicine, Dudley Group of Hospitals, West Midlands, UK. Department of
Haematology, Dudley Group of Hospitals, West Midlands, UK. Department of Gastroenterology, Dudley
Group of Hospitals, West Midlands, UK.
Welder's siderosis occurs as a consequence of the inhalation of iron dust. The iron overload of
welder's siderosis is usually considered to be confined to the lungs. Here we present three proven
cases of welder's siderosis associated with evidence of increased total systemic iron stores, as
evidenced by increased serum ferritin levels. Multiple investigations including molecular genotyping
for the common mutations found in genetic haemochromatosis failed to prove this was due to
haemochromatosis, nor was there any evidence of any other recognised cause of systemic iron
overload. Thus the systemic iron overload described seems likely to be due to either occupational
exposure, an uncharacterised genetic haemochromatosis, or a combination of both.
PMID: 14691279 [PubMed - in process]
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