O
Orac
Guest
In article <[email protected]>,
"Marko Proberto" <[email protected]> wrote:
> "George Conklin" <[email protected]> wrote in message
> news:[email protected]...
> >
> > "Orac" <[email protected]> wrote in message
> > news[email protected]...
> > > In article <[email protected]>,
> > > "George Conklin" <[email protected]> wrote:
> > >
> > > > "Orac" <[email protected]> wrote in message
> > > > news[email protected]...
> > > > > In article <[email protected]>,
> > > > > "George Conklin" <[email protected]> wrote:
> > >
> > > > > > You could have picked a lot better examples than chelation.
> > > > >
> > > > > It's a perfectly fine example. Chelation therapy has never been
> shown
> > to
> > > > > be effective for atherosclerotic disease. There has yet to be a good
> > > > > randomized study that shows its efficacy in this. The one randomized
> > > > > trial that reported a positive result was done was very small (only
> > ten
> > > > > patients), and the investigators never followed up on it, to the
> best
> > of
> > > > > my knowledge. Since then, there have been at least four randomized
> > > > > studies, none of which showed a treatment effect and (more
> > importantly)
> > > > > none of which showed objective evidence that chelation therapy
> reduces
> > > > > the size of atherosclerotic plaques (a key claim by chelation
> therapy
> > > > > advocates that even they have had to back away from in the last
> couple
> > > > > of years--in favor of various handwaving "explanations" about how
> > > > > chelation therapy "works"). The very best thing that can be said
> about
> > > > > chelation therapy is that it is unproven. As such, responsible
> > medicine
> > > > > dictates that it should not be used as a treatment for
> atherosclerotic
> > > > > heart disease or peripheral vascular disease outside of a clinical
> > > > > trial. (Note that it is known to be effective for acute heavy metal
> > > > > poisoning; using chelation for this particular indication is not
> > > > > quackery.)
> > > > >
> > > > > FYI, the National Center for Complementary and Alternative Medicine
> > > > > recently started accruing patients for a double-blinded,
> > > > > placebo-controlled, randomized clinical trial that should
> (hopefully)
> > > > > answer the question once and for all. I have no problem with this
> > study,
> > > > > but, knowing how alties almost never give up on a therapy no matter
> > how
> > > > > much evidence shows it to be ineffective, I predict that, even if
> the
> > > > > trial conclusively shows no benefit, alties will still be pushing
> > > > > chelation therapy years after I've passed on. (Indeed, even if there
> > > > > were dozens of well-designed studies showing that chelation therapy
> > > > > didn't work, I'd predict that alties would keep pushing it.) In
> > > > > contrast, I predict that, if the study shows that it has some
> > efficacy,
> > > > > conventional cardiologists will start to adopt it. Therein lies one
> > > > > difference between quacks and conventional doctors.
> > > > >
> > > >
> > > > Your last point is the issue: no one is looking to see if it
> > effective
> > > > or not.
> > >
> > > Wrong, George. I just made it a point to tell you that there is
> > > presently a large randomized, double-blinded, placebo-controlled
> > > clinical trial supported by the NIH looking at chelation therapy for
> > > atherosclerotic heart disease. I rather suspect that it will show no
> > > benefit, but if it does show a definite benefit I again predict that
> > > cardiologists will start to adopt it. I also suspect that, if it does
> > > show a benefit, it will probably be small. (If it produced a large
> > > benefit, chances are the benefit would have been observed in the smaller
> > > randomized studies that have already been done.)
> > >
> >
> > And how long has this study been delayed? 45-50 years, right?
>
> There were previous studies which showed no benefit. This study, using mor
> emodern testing will, hopefully, answer the question.
>
> Yes, I am not holding my breath.
Indeed. Chelation therapy was studied on and off for a long time.
Remember, I said it was only in the last 15 years or so that randomized
blinded studies were done with placebo controls. All of them save one
have shown no benefit, and the one that purported to show a benefit was
a tiny study (10 patients) that its investigators never followed up on.
One thing's for sure: If chelation was truly as beneficial as its
proponents claimed, chances are that the studies that have already been
done would have shown it. My guess is that, if there is any benefit
found at all (which is rather unlikely) it will be quite small.
--
Orac |"A statement of fact cannot be insolent."
|
|"If you cannot listen to the answers, why do you
| inconvenience me with questions?"
"Marko Proberto" <[email protected]> wrote:
> "George Conklin" <[email protected]> wrote in message
> news:[email protected]...
> >
> > "Orac" <[email protected]> wrote in message
> > news[email protected]...
> > > In article <[email protected]>,
> > > "George Conklin" <[email protected]> wrote:
> > >
> > > > "Orac" <[email protected]> wrote in message
> > > > news[email protected]...
> > > > > In article <[email protected]>,
> > > > > "George Conklin" <[email protected]> wrote:
> > >
> > > > > > You could have picked a lot better examples than chelation.
> > > > >
> > > > > It's a perfectly fine example. Chelation therapy has never been
> shown
> > to
> > > > > be effective for atherosclerotic disease. There has yet to be a good
> > > > > randomized study that shows its efficacy in this. The one randomized
> > > > > trial that reported a positive result was done was very small (only
> > ten
> > > > > patients), and the investigators never followed up on it, to the
> best
> > of
> > > > > my knowledge. Since then, there have been at least four randomized
> > > > > studies, none of which showed a treatment effect and (more
> > importantly)
> > > > > none of which showed objective evidence that chelation therapy
> reduces
> > > > > the size of atherosclerotic plaques (a key claim by chelation
> therapy
> > > > > advocates that even they have had to back away from in the last
> couple
> > > > > of years--in favor of various handwaving "explanations" about how
> > > > > chelation therapy "works"). The very best thing that can be said
> about
> > > > > chelation therapy is that it is unproven. As such, responsible
> > medicine
> > > > > dictates that it should not be used as a treatment for
> atherosclerotic
> > > > > heart disease or peripheral vascular disease outside of a clinical
> > > > > trial. (Note that it is known to be effective for acute heavy metal
> > > > > poisoning; using chelation for this particular indication is not
> > > > > quackery.)
> > > > >
> > > > > FYI, the National Center for Complementary and Alternative Medicine
> > > > > recently started accruing patients for a double-blinded,
> > > > > placebo-controlled, randomized clinical trial that should
> (hopefully)
> > > > > answer the question once and for all. I have no problem with this
> > study,
> > > > > but, knowing how alties almost never give up on a therapy no matter
> > how
> > > > > much evidence shows it to be ineffective, I predict that, even if
> the
> > > > > trial conclusively shows no benefit, alties will still be pushing
> > > > > chelation therapy years after I've passed on. (Indeed, even if there
> > > > > were dozens of well-designed studies showing that chelation therapy
> > > > > didn't work, I'd predict that alties would keep pushing it.) In
> > > > > contrast, I predict that, if the study shows that it has some
> > efficacy,
> > > > > conventional cardiologists will start to adopt it. Therein lies one
> > > > > difference between quacks and conventional doctors.
> > > > >
> > > >
> > > > Your last point is the issue: no one is looking to see if it
> > effective
> > > > or not.
> > >
> > > Wrong, George. I just made it a point to tell you that there is
> > > presently a large randomized, double-blinded, placebo-controlled
> > > clinical trial supported by the NIH looking at chelation therapy for
> > > atherosclerotic heart disease. I rather suspect that it will show no
> > > benefit, but if it does show a definite benefit I again predict that
> > > cardiologists will start to adopt it. I also suspect that, if it does
> > > show a benefit, it will probably be small. (If it produced a large
> > > benefit, chances are the benefit would have been observed in the smaller
> > > randomized studies that have already been done.)
> > >
> >
> > And how long has this study been delayed? 45-50 years, right?
>
> There were previous studies which showed no benefit. This study, using mor
> emodern testing will, hopefully, answer the question.
>
> Yes, I am not holding my breath.
Indeed. Chelation therapy was studied on and off for a long time.
Remember, I said it was only in the last 15 years or so that randomized
blinded studies were done with placebo controls. All of them save one
have shown no benefit, and the one that purported to show a benefit was
a tiny study (10 patients) that its investigators never followed up on.
One thing's for sure: If chelation was truly as beneficial as its
proponents claimed, chances are that the studies that have already been
done would have shown it. My guess is that, if there is any benefit
found at all (which is rather unlikely) it will be quite small.
--
Orac |"A statement of fact cannot be insolent."
|
|"If you cannot listen to the answers, why do you
| inconvenience me with questions?"