I never thought of wearing anything between me and the shorts. They are designed to be work agaisnt the skin.
I just biked the Blue Rodge Parkway a couple weeks ago...six days of riding and about 7-8 hours a day in the saddle. I did develop some saddle rash, even with chamois cream, becasue some seams of my chamois on one pair of shorts dry rotted and was a bit crackly.
I was considering wearing my shorts inside-out since the lycra surface seemed more inviting thqan the seams of my chamois. I never braved that becasue I didn't wnat to make things worse. It lead me to wonder why chamois aren't lined with somehting slick like lycra on both sides. Chaffing come from friction and moistire and I would think the friction would be reduced by the lycra. Just wondering why nobody has tried to revolutionize bike short designs. Everything else in cycling has been revolutionized recently.
I do have a pair of UnderArmor compression shorts at home that I got as a freebie, and may give them a try on a long ride. They come down the leg about as far as a pair or cycling shorts. I'll let you know how it works, but I won't take pics...