and +75% risk for colorectal adenoma...
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16393237&query_hl=1&itool=pubmed_docsum
: Am J Gastroenterol. 2005 Dec;100(12):2789-95.
Fat, fiber, meat and the risk of colorectal adenomas.
Robertson DJ, Sandler RS, Haile R, Tosteson TD, Greenberg ER, Grau
M, Baron JA.
Veterans Hospital, White River Junction, Vermont, and Department
of Medicine, Dartmouth Medical School, Hanover, New Hampshire, USA.
OBJECTIVE: The aim of this study was to determine the relationship
between fat, fiber, and meat intake, and risk of colorectal adenoma
recurrence. METHODS: We determined adenoma recurrence and dietary
intake for 1,520 participants in two randomized trials: The
Antioxidant Polyp Prevention Study and Calcium Polyp Prevention Study.
Subjects underwent baseline colonoscopy with removal of all adenomas,
and dietary intake was estimated with a validated semiquantitative
food frequency questionnaire. Follow-up colonoscopy was performed 1
and 4 yr later. Pooled risk ratios for adenoma recurrence were
obtained by generalized linear regression, with adjustment for age,
sex, clinical center, treatment category, study, and duration of
observation. RESULTS: In the total colorectum, fiber intake was weakly
and nonsignificantly associated with a risk for all adenomas (RR
quartile 4 vs quartile 1=0.85, 95% CI 0.69-1.05) and advanced adenomas
(RR=0.88, 95% CI 0.54-1.44). Associations were stronger for adenomas
in the proximal colon (RR=0.73, 95% CI 0.56-0.97) and some fiber
subtypes (fruit and vegetable, grain). There was no association
between fat or total red meat intake and risk of adenoma or advanced
adenoma recurrence. However, when considering other meats, risk
(quartile 4 vs quartile 1) for advanced adenoma was increased for
processed meat (RR=1.75, 95% CI 1.02-2.99) and decreased for chicken
(RR=0.61, 95% CI 0.38-0.98). CONCLUSION: The inverse associations
between fiber intake and risk of adenoma recurrence we observed are
weak, and not statistically significant. Our data indicate that intake
of specific meats may have different effects on risk.
PMID: 16393237 [PubMed - in process]
X'Posted to: sci.med.nutrition,sci.bio.food-science