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Thermodynamics and Metabolic Advantage of Weight Loss Diets

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General fitness, health and nutrition
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29 December 2004
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jbuch
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  1. Links to the actual published full articles involved are given below.

    Caution, actually uses equations and large tables of data.

    Thermodynamics and Metabolic Advantage of Weight Loss Diets

    Richard D. Feinman, PhD, Eugene J. Fine, MD
    Metabolic Syndrome and Related Disorders
    September 2003, Vol. 1, No. 3, Pages 209-219
    Posted online on July 8, 2004.
    (doi:10.1089/154041903322716688)

    http://www.liebertonline.com/doi/abs/10.1089%2F154041903322716688?cookieSet=1

    "A calorie is a calorie" violates the second law of thermodynamics

    Richard D Feinman1 and Eugene J Fine1,
    Department of Biochemistry, State University of New York Downstate
    Medical Center, Brooklyn, NY 11203 USA
    2Department of Nuclear Medicine, Jacobi Medical Center, Bronx, NY 10461 USA

    Nutrition Journal 2004, 3:9 doi:10.1186/1475-2891-3-9

    AbstractThe principle of "a calorie is a calorie," that weight change in
    hypocaloric diets is independent of macronutrient composition, is widely
    held in the popular and technical literature, and is frequently
    justified by appeal to the laws of thermodynamics. We review here some
    aspects of thermodynamics that bear on weight loss and the effect of
    macronutrient composition. The focus is the so-called metabolic
    advantage in low-carbohydrate diets – greater weight loss compared to
    isocaloric diets of different composition. Two laws of thermodynamics
    are relevant to the systems considered in nutrition and, whereas the
    first law is a conservation (of energy) law, the second is a dissipation
    law: something (negative entropy) is lost and therefore balance is not
    to be expected in diet interventions. Here, we propose that a
    misunderstanding of the second law accounts for the controversy about
    the role of macronutrient effect on weight loss and we review some
    aspects of elementary thermodynamics. We use data in the literature to
    show that thermogenesis is sufficient to predict metabolic advantage.
    Whereas homeostasis ensures balance under many conditions, as a general
    principle, "a calorie is a calorie" violates the second law of
    thermodynamics.

    http://www.nutritionj.com/content/3/1/9

  2. jbuch said:

    Links to the actual published full articles involved are given below.

    Caution, actually uses equations and large tables of data.

    Thermodynamics and Metabolic Advantage of Weight Loss Diets

    Richard D. Feinman, PhD, Eugene J. Fine, MD
    Metabolic Syndrome and Related Disorders
    September 2003, Vol. 1, No. 3, Pages 209-219
    Posted online on July 8, 2004.
    (doi:10.1089/154041903322716688)


    http://www.liebertonline.com/doi/abs/10.1089%2F154041903322716688?cookieSet=1

    Very interesting. Everyone seems to know about "calories consumed", but how
    about "calorires excreted".

    You could define, say:
    calories burned = calories consumed - calories excreted
    eating "octane ratio" = calories burned/calories consumed * 100

    I looks like, given diets with identical total calories, the body readily
    absorbs carbs more than protein.

    gtoomey

  3. Wozza said:

    Very interesting. Everyone seems to know about "calories consumed", but how
    about "calorires excreted".

    You could define, say:
    calories burned = calories consumed - calories excreted
    eating "octane ratio" = calories burned/calories consumed * 100

    Rarely mentioned in this whole "counting cals" lunacy is that what goes in
    your mouth is not necessarily even close to what is "pulled" into (use) in
    your system.

    Think corn kernels and your [censored].

    So, you start with a cal counting "handbook", you mix in the fact that the
    handbook is a guesstimate, then you don't weigh your food to know whether
    that steak is 4 or 5.1 ounces, much less the veggies and deserts, add food
    that passes through the gut relatively untouched (and never subtracted from
    the cals intake) and you have about as useless a system as one can imagine.

    Of course, you get the "privilege" of wasting your time writing down this
    mess of inaccuracies to boot.

  4. MU said:
    Wozza said:

    Very interesting. Everyone seems to know about "calories consumed", but how
    about "calorires excreted".

    You could define, say:
    calories burned = calories consumed - calories excreted
    eating "octane ratio" = calories burned/calories consumed * 100

    Rarely mentioned in this whole "counting cals" lunacy is that what goes in
    your mouth is not necessarily even close to what is "pulled" into (use) in
    your system.

    Think corn kernels and your [censored].

    So, you start with a cal counting "handbook", you mix in the fact that the
    handbook is a guesstimate, then you don't weigh your food to know whether
    that steak is 4 or 5.1 ounces, much less the veggies and deserts, add food
    that passes through the gut relatively untouched (and never subtracted from
    the cals intake) and you have about as useless a system as one can imagine.

    Of course, you get the "privilege" of wasting your time writing down this
    mess of inaccuracies to boot.

    Who the hell knows, I mean really? What seems to hold true for one
    person doesn't work at all for another.

    I have read on this ng (alt.support.diet), reports of people who
    essentially eat the same diet and yet lose weight by increasing their
    exercise level. For me, I can kill myself exercising and eating the
    same diet and *nothing* happens, I'm sure that there are people who
    experience the same thing with calorie restriction.

    Judging from this group, of the umteem jillion obese people in the
    world, there are a relative few who have figured out what works.

    Em

    -----
    When in trouble or in doubt,
    Run in circles, scream and shout.

  5. Auntie Em said:


    I have read on this ng (alt.support.diet), reports of people who
    essentially eat the same diet and yet lose weight by increasing their
    exercise level. For me, I can kill myself exercising and eating the
    same diet and *nothing* happens, I'm sure that there are people who
    experience the same thing with calorie restriction.

    There was a very good medical study published in the past couple months
    that proved that while many people do, in fact, lose weight with
    exercise, there are quite a few others, who have some kind of genetic
    difference in how their muscle metabolisms work, do not.

    I know I'm one of those in the latter category and always have been.
    Exercise will make my muscles look nicer but does not make me lose weight.
    --Jenny Type 2 diabetes since 1998. Hba1c 5.7%
    Low Carbing for 5 years. 140 lbs (goal)

    Cut the "carbs" to respond to my email address.
    -----------------------------------------------------
    What they Don't Tell You About Diabetes Web Site
    http://www.geocities.com/lottadata4u/

    Jenny's Low Carb Diet Facts & Figures site
    http://www.geocities.com/jenny_the_bean/

    Looking for help controlling your blood sugar?
    Visit http://www.alt-support-diabetes.org/Newly%20Diagnosed.htm
    ----------------------------------------------------------------

  6. Mu:
    "Rarely mentioned in this whole "counting cals" lunacy is that what
    goes in
    your mouth is not necessarily even close to what is "pulled" into (use)
    in
    your system.

    Think corn kernels and your [censored]."

    It's not mentioned in counting cals, but it is indeed focused on in
    Atkins, where fiber gets subtracted
    from the carb count. Seems Atkins was right!

  7. "There was a very good medical study published in the past couple
    months
    that proved that while many people do, in fact, lose weight with
    exercise, there are quite a few others, who have some kind of genetic
    difference in how their muscle metabolisms work, do not."

    I can see how this could be true for modest amounts of excercise. But
    if you increase excercise a
    lot and maintain the same diet, it's hard to see how this is possible.
    The extra energy burned
    has to come from somewhere. Some of the weight will be converted to
    muscle, but it's hard to
    figure out how they could not lose some weight in the process.
    Do you have a link to the study?

  8. "Roger Zoul" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:


    "Ignoramus31471" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:

    On 31 Dec 2004 16:35:54 GMT, [email hidden]


    Quoted message said:
    Quoted message said:

    "I have read on this ng (alt.support.diet), reports of people who
    essentially eat the same diet and yet lose weight by increasing their
    exercise level. For me, I can kill myself exercising and eating the
    same diet and *nothing* happens, I'm sure that there are people who
    experience the same thing with calorie restriction.

    Judging from this group, of the umteem jillion obese people in the
    world, there are a relative few who have figured out what works."

    Calories work. Exercise uses fairly few calories per sey if one


    consults

    Quoted message said:
    Quoted message said:

    the charts showing activity and calories per hour. Exercise primes


    the

    Quoted message said:
    Quoted message said:
    Quoted message said:

    body for more weight loss because the effect which is using calories
    during exercise continues up to 48 hours after the exercise stops,ie.


    the

    Quoted message said:
    Quoted message said:

    body is in a greater calorie using mode

    "up to 48 hours" is not true for many forms of exercise, namely those that
    don't drive HR up.

    . Calories work, there were no

    Quoted message said:
    Quoted message said:

    obese people to survive the camps in europe. The way each of our


    bodies

    Quoted message said:
    Quoted message said:
    Quoted message said:

    is set up to react to fewer calories differes and most people lose


    weight

    Quoted message said:
    Quoted message said:

    when a few hundred calories less per day are eaten over time.

    You are forgetting that a person who exercises may conceivably be
    hungrier and eat more.

    Again. Exercise helps some people to lose weight and it does not help
    other people. Also, some people's fitness is not improved by exercise,
    as strange as it sounds.

    the number of people who don't benefit from exericse are far and few
    between. And below you only list one article...there is great risk in
    assuming it is the last word on whether exercise is not beneficial for


    even

    Quoted message said:

    a small number of people. There could be many issue at play that produced
    those results.

    I have noticed that some people's perception of effort seems to be
    warped, which would cause them to believe that exercise does not help them.
    I saw a woman in the gym once that was arm curling with small pink 2lb
    weights and leg pressing with 20lbs on the machine. She appeared to be
    getting a serious workout by looking at her facial expressions. In reality,
    an average grocery shopping trip would be more strenuous. 10 bags weighing
    5lbs each, carried up a flight of stairs would be more of an effort than the
    weights she was using. In order to build muscle, a person has to stress them
    by lifting more than they normally do. Genetic factors would of course limit
    the amount of muscle that could be obtained.

    Quoted message said:


    Quoted message said:


    Exercise is not a cure all and it is not always helpful for
    everyone.

    Perhaps.

    Quoted message said:

    If you are one of the lucky people who do benefit from
    exercise, count your blessings.

    The vast majority fall into this group, even according to that article.

    Quoted message said:

    I am also one of those lucky people. I
    am slim and fit, and exercise, so please do not construe my message as
    though i am making some sort of an excuse for not exercising or
    staying fat.

    ======================================================================

    Some people are 'immune' to exercise

    10:45 02 December 04

    http://www.newscientist.com/news/news.jsp?id=ns99996735

    Exclusive from New Scientist Print Edition.

    Public-health campaigns regularly plug exercise as a sure-fire way to
    avoid an early grave. But that message may be too simplistic. For an
    unhappy few, even quite strenuous exercise may have no effect on their
    fitness or their risk of developing diseases like diabetes.

    "There is astounding variation in the response to exercise. The vast
    majority will benefit in some way, but there will be a minority who will
    not benefit at all," says Claude Bouchard of Louisiana State University
    in Baton Rouge, US.

    At the Australian Health and Medical Research Congress in Sydney,
    Australia, last week Bouchard reported the results of a study assessing
    the role of genes in fitness and health changes in response to exercise.

    In the study, 742 people from 213 families were put through a strict
    20-week endurance training programme. The volunteers had not taken
    regular physical activity for the previous six months. Exercise on
    stationary bikes was gradually increased so that by the last six weeks
    the volunteers were exercising for 50 minutes three times a week at 75%
    of the maximum output they were capable of before the study.

    Previous reports indicated that there are huge variations in
    "trainability" between subjects. For example, the team found that
    training improved maximum oxygen consumption, a measure of a person's
    ability to perform work, by 17% on average.

    But the most trainable volunteers gained over 40%, and the least
    trainable showed no improvement at all. Similar patterns were seen with
    cardiac output, blood pressure, heart rate and other markers of fitness.

    Weblinks

    Pennington Biomedical Research Center, Louisiana State University

    Australian Health and Medical Research Congress

    Institute of Neuromuscular Research, Children's Hospital, Westmead

    School of Exercise and Nutrition Sciences, Deakin University

    Bouchard reported that the impact of training on insulin sensitivity - a
    marker of risk for diabetes and heart disease - also varied. It improved
    in 58% of the volunteers following exercise, but in 42% it showed no
    improvement or, in a few cases, may have got worse.

    "It's negative, but it's true. Some people slog away and don't get any
    improvement," says Kathryn North of the Institute of Neuromuscular
    Research at the Children's Hospital at Westmead in Sydney, Australia.

    In the eight volunteers who showed the largest improvement in insulin
    sensitivity, 51 genes were expressed in muscles at double the levels of
    the eight people who showed the least improvement, and 74 genes were
    expressed at half the level. Many of these genes were a surprise to the
    researchers because they have not previously been linked to exercise.

    "We need to recognise that although on average exercise may have clear
    benefits, it may not work for everyone," says Mark Hargreaves of Deakin
    University in Melbourne, Australia. "Some people may do better to change
    their diet."

    Rachel Nowak, Sydney
    --
    ...............................

    Keepsake gift for young girls.
    Unique and personal one-of-a-kind.
    Builds strong minds 12 ways.
    Guaranteed satisfaction
    - courteous money back
    - keep bonus gifts

    http://www.alicebook.com

    --
    223/172.3/180

  9. Quoted message said:

    I can see how this could be true for modest amounts of excercise. But
    if you increase excercise a
    lot and maintain the same diet, it's hard to see how this is possible.
    The extra energy burned
    has to come from somewhere. Some of the weight will be converted to
    muscle, but it's hard to
    figure out how they could not lose some weight in the process.
    Do you have a link to the study?

    Here's the link to the article, from the Dec. 2004 New Scientist,
    entitled "Some People are Immune to Exercise".

    http://www.newscientist.com/article.ns?id=dn6735

    Here is a portion of that article:
    In the study, 742 people from 213 families were put through a strict
    20-week endurance training programme. The volunteers had not taken
    regular physical activity for the previous six months. Exercise on
    stationary bikes was gradually increased so that by the last six weeks
    the volunteers were exercising for 50 minutes three times a week at 75%
    of the maximum output they were capable of before the study.

    <snip>
    But the most trainable volunteers gained over 40%, and the least
    trainable showed no improvement at all. Similar patterns were seen with
    cardiac output, blood pressure, heart rate and other markers of fitness.
    Slogging away

    Bouchard reported that the impact of training on insulin sensitivity – a
    marker of risk for diabetes and heart disease – also varied. It improved
    in 58% of the volunteers following exercise, but in 42% it showed no
    improvement or, in a few cases, may have got worse.

    “It’s negative, but it’s true. Some people slog away and don’t get any
    improvement,” says Kathryn North of the Institute of Neuromuscular
    Research at the Children’s Hospital at Westmead in Sydney, Australia.

    In the eight volunteers who showed the largest improvement in insulin
    sensitivity, 51 genes were expressed in muscles at double the levels of
    the eight people who showed the least improvement, and 74 genes were
    expressed at half the level. Many of these genes were a surprise to the
    researchers because they have not previously been linked to exercise.

    “We need to recognise that although on average exercise may have clear
    benefits, it may not work for everyone,” says Mark Hargreaves of Deakin
    University in Melbourne, Australia. “Some people may do better to change
    their diet.”

    --Jenny Type 2 diabetes since 1998. Hba1c 5.7%
    Low Carbing for 5 years. 140 lbs (goal)

    Cut the "carbs" to respond to my email address.
    -----------------------------------------------------
    What they Don't Tell You About Diabetes Web Site
    http://www.geocities.com/lottadata4u/

    Jenny's Low Carb Diet Facts & Figures site
    http://www.geocities.com/jenny_the_bean/

    Looking for help controlling your blood sugar?
    Visit http://www.alt-support-diabetes.org/Newly%20Diagnosed.htm
    ----------------------------------------------------------------

  10. "Jenny" <[email hidden]> wrote in message
    news:[email hidden]...

    Quoted message said:
    Quoted message said:

    I can see how this could be true for modest amounts of excercise. But
    if you increase excercise a
    lot and maintain the same diet, it's hard to see how this is possible.
    The extra energy burned
    has to come from somewhere. Some of the weight will be converted to
    muscle, but it's hard to
    figure out how they could not lose some weight in the process.
    Do you have a link to the study?

    Here's the link to the article, from the Dec. 2004 New Scientist,
    entitled "Some People are Immune to Exercise".

    http://www.newscientist.com/article.ns?id=dn6735

    Here is a portion of that article:
    In the study, 742 people from 213 families were put through a strict
    20-week endurance training programme. The volunteers had not taken
    regular physical activity for the previous six months. Exercise on
    stationary bikes was gradually increased so that by the last six weeks
    the volunteers were exercising for 50 minutes three times a week at 75%
    of the maximum output they were capable of before the study.

    So...these volunteers had not taken regular phsical activity for the
    previous six months. We don't know if they did anything prior to that
    either.

    So, by the last six week they were exercsing for 50 minutes 3x per week at
    75% of the maximum output there were capable of before the study.

    Maybe I'm jaded, but I see lots of possibilities there for some [censored]
    results. How was the maximum output determined? If some of these people
    had been sedentary for long before, they may have very low output as they
    are not used to exercise. And if their true maximum output was not
    correctly determined, say by them not pushing hard enough or them not being
    pushed hard enough due to concerns for their safety, then what? They (or
    some) might have been exercisng at 75% of what could have been an
    artificially low level in the first place.

    Frankly, I think this work needs to be corroborated by other studies before
    given any weight. Only one type of exercise was used.

    The comment below about diet needs some attention too. What were these
    folks eating during this time? Did their weight stay the same or did it
    change (up or down)? It seems to be that diet makes a huge difference in
    nearly everything a human being does. Does this study really isolate the
    effect of exercise on the particiants? Could diet and other lifestyle
    issues mask benefits of exercise for some of these folks?

    Quoted message said:


    <snip>
    But the most trainable volunteers gained over 40%, and the least
    trainable showed no improvement at all. Similar patterns were seen with
    cardiac output, blood pressure, heart rate and other markers of fitness.
    Slogging away

    Bouchard reported that the impact of training on insulin sensitivity – a
    marker of risk for diabetes and heart disease – also varied. It improved
    in 58% of the volunteers following exercise, but in 42% it showed no
    improvement or, in a few cases, may have got worse.

    “It’s negative, but it’s true. Some people slog away and don’t get any
    improvement,” says Kathryn North of the Institute of Neuromuscular
    Research at the Children’s Hospital at Westmead in Sydney, Australia.

    In the eight volunteers who showed the largest improvement in insulin
    sensitivity, 51 genes were expressed in muscles at double the levels of
    the eight people who showed the least improvement, and 74 genes were
    expressed at half the level. Many of these genes were a surprise to the
    researchers because they have not previously been linked to exercise.

    “We need to recognise that although on average exercise may have clear
    benefits, it may not work for everyone,” says Mark Hargreaves of Deakin
    University in Melbourne, Australia. “Some people may do better to change
    their diet.”

    --Jenny Type 2 diabetes since 1998. Hba1c 5.7%
    Low Carbing for 5 years. 140 lbs (goal)

    Cut the "carbs" to respond to my email address.
    -----------------------------------------------------
    What they Don't Tell You About Diabetes Web Site
    http://www.geocities.com/lottadata4u/

    Jenny's Low Carb Diet Facts & Figures site
    http://www.geocities.com/jenny_the_bean/

    Looking for help controlling your blood sugar?
    Visit http://www.alt-support-diabetes.org/Newly%20Diagnosed.htm
    ----------------------------------------------------------------

  11. Jenny said:


    Quoted message said:

    I can see how this could be true for modest amounts of excercise. But
    if you increase excercise a
    lot and maintain the same diet, it's hard to see how this is possible.
    The extra energy burned
    has to come from somewhere. Some of the weight will be converted to
    muscle, but it's hard to
    figure out how they could not lose some weight in the process.
    Do you have a link to the study?

    Here's the link to the article, from the Dec. 2004 New Scientist,
    entitled "Some People are Immune to Exercise".

    http://www.newscientist.com/article.ns?id=dn6735

    Here is a portion of that article:
    In the study, 742 people from 213 families were put through a strict
    20-week endurance training programme. The volunteers had not taken
    regular physical activity for the previous six months. Exercise on
    stationary bikes was gradually increased so that by the last six weeks
    the volunteers were exercising for 50 minutes three times a week at 75%
    of the maximum output they were capable of before the study.

    <snip>
    But the most trainable volunteers gained over 40%, and the least
    trainable showed no improvement at all. Similar patterns were seen with
    cardiac output, blood pressure, heart rate and other markers of fitness.
    Slogging away

    Bouchard reported that the impact of training on insulin sensitivity – a
    marker of risk for diabetes and heart disease – also varied. It improved
    in 58% of the volunteers following exercise, but in 42% it showed no
    improvement or, in a few cases, may have got worse.

    “It’s negative, but it’s true. Some people slog away and don’t get any
    improvement,” says Kathryn North of the Institute of Neuromuscular
    Research at the Children’s Hospital at Westmead in Sydney, Australia.

    In the eight volunteers who showed the largest improvement in insulin
    sensitivity, 51 genes were expressed in muscles at double the levels of
    the eight people who showed the least improvement, and 74 genes were
    expressed at half the level. Many of these genes were a surprise to the
    researchers because they have not previously been linked to exercise.

    “We need to recognise that although on average exercise may have clear
    benefits, it may not work for everyone,” says Mark Hargreaves of Deakin
    University in Melbourne, Australia. “Some people may do better to change
    their diet.”

    The specific change would be eating less.

    "Eating less is necessary and sufficient for losing weight."

    You read it here first...

    ....now enter the 2PD Approach:

    http://www.heartmdphd.com/wtloss.asp

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    Andrew

    --
    Andrew B. Chung, MD/PhD
    Board-Certified Cardiologist

    **
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  12. Jenny wrote and quoted the below article:

    Quoted message said:

    Here's the link to the article, from the Dec. 2004 New Scientist,
    entitled "Some People are Immune to Exercise".
    http://www.newscientist.com/article.ns?id=dn6735

    Thank you Jenny for the excellent link. However I believe the
    journalist is trying to put her own sensational spin by the headline:

    "Some people are 'immune' to exercise".

    I couldn't find this anywhere implied in the full text below. Perhaps
    someone could look at the full text that has a statistically inclined
    medical background and see this implied?

    Here is the full text:
    http://jap.physiology.org/cgi/content/full/90/5/1770?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=claude+bouchard&searchid=1105167263812_7070&stored_search=&FIRSTINDEX=0&volume=90&issue=5

    And two quotes from the paper:

    "Individual responses varied widely, but Vo2max increased
    significantly for all groups"

    "In summary, we have shown in a large heterogeneous, biracial,
    sedentary population that age, sex, race, and initial fitness level
    have little or no effect on the response of Vo2max to a standardized
    20-wk endurance exercise training program. There appear to be high,
    medium, and low responders to training at all ages, in both sexes, in
    both races, and at all levels of initial fitness studied. Genetics may
    help explain the large variation in training response in these
    subjects."

    The above studies low exercise regiment (75% maxVo2), probably only
    burned around 1250 calories per week (2.5hour * 500cals). This other
    study took the subjects to 83% peak heart rate with fantastic results.
    http://jap.physiology.org/cgi/content/abstract/98/1/40

    At 85%-110% MHR 2-6 hrs at a time (biking up to 100miles), can lower
    this X-hypertensive 56yo's BP => 10mmHg the next day after
    rehydrating. Plus since changing from jogging (due to arthritic joints)
    to prolonged low impact exercising (1-8 hrs day) my HDL has steadily
    increased from a 47 low to 101 over several years. I admire your
    ability to tolerate low-carbing, as for myself it had my LDL >160s for
    2 years (now 70's). I just do CRONE and frequently to my surprise eat
    a non-sugar high fiber diet of < 2 lbs per day (10 day avg multiple
    times), just to maintain my weight. I may be pre MetS or have such a
    predisposition?

    CU. Mike.

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