http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Ab
stract&list_uids=15382070&itool=iconabstr&query_hl=4
Department of Nutritional Sciences, Faculty of Medicine, University of
Toronto, Toronto, Canada.
Dietary carbohydrates have different glycemic and insulinemic potentials
depending on type (glycemic index, GI) and amount (glycemic load, GL) of
carbohydrate consumed or both. Insulin in turn has been implicated as a risk
factor for several cancers, including that of the prostate. We assessed the
relationship of GI and GL with prostate cancer risk in a multicenter
case-control study. Cases and controls were recruited between 1991 and 2002
in the network of major teaching and general hospitals in 4 Italian areas.
Cases were 1,204 men (age range 46-74 years) admitted for incident,
histologically confirmed prostate cancer. Controls were 1,352 men (age range
46-74 years) admitted for acute, nonmalignant conditions unrelated to
long-term modifications of diet. ORs of prostate cancer and the
corresponding 95% CIs were derived using unconditional multiple logistic
regression, including terms for age, study center, education, family history
of prostate cancer, smoking, body mass index, physical activity, alcohol
consumption, intake of energy, fiber and lycopenes. Compared to the lowest
quintile of GI, the ORs were 1.23, 1.24, 1.47 and 1.57 for subsequent levels
of GI. The corresponding values for GL were 0.91, 1.00, 1.20 and 1.41. No
heterogeneity was found among strata of selected covariates. We found direct
relations between dietary GI and GL and prostate cancer risk. Correcting for
potential confounding factors did not substantially modify these
associations.