Effect of a novel water-soluble vitamin E derivative as a cure for
TNBS-induced colitis in rats.
Isozaki Y, Yoshida N, Kuroda M, Takagi T, Handa O, Kokura S, Ichikawa
H, Naito Y, Okanoue T, Yoshikawa T
Int J Mol Med. 2006 Mar ; 17(3): 497-502
Lipid peroxidation mediated by oxygen free radicals plays an important
role in the pathogenesis of inflammatory bowel disease (IBD). Vitamin E
is a lipid-soluble antioxidant and is generally considered to protect
against lipid peroxidation of the cell membrane and to scavenge singlet
oxygen and superoxide anion radical. Therefore, vitamin E or its
derivatives are expected to have particular application for patients
suffering from IBD. The aim of this study was to investigate the
antioxidative effects of the water-soluble vitamin E derivative,
2-(alpha-D-glucopyranosyl)methyl-2,5,7,8-tetra-methylchroman-6-ol(TMG),
on the therapy of experimental colitis in rats. Colitis was induced in
male Wistar rats weighing 200 g using an enema of trinitrobenzene
sulfonic acid (TNBS) dissolved in 50% ethanol; TMG dissolved in
physiological saline was injected intra-peritoneally every day from 24
h after the enema of TNBS. The damage score, wet weight of the colon,
and increase in body weight were estimated 1 week after the enema of
TNBS. Thiobarbituric acid-reactive substances (TBA-RS), an index of
lipid peroxidation, and tissue-associated myeloperoxidase (MPO)
activity in the colonic mucosa were measured 1 week after the induction
of colitis. As a result, increase in body weight was inhibited by the
induction of colitis, although the inhibition was reduced in the group
treated with TMG. The damage score, wet weight, TBA-RS and MPO activity
were increased significantly in the colitis group; however, they were
inhibited by the administration of TMG. These results suggest that TMG
is effective for the treatment of colitis in rats induced by TNBS. In
the future, TMG could be a new therapeutic agent for IBD.
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