Effects of a hypocaloric, low-carbohydrate diet on overweight women

Matti Narkia said:

In their 8-week trial

Meckling KA, Gauthier M, Grubb R, Sanford J.
Effects of a hypocaloric, low-carbohydrate diet on weight loss, blood lipids,
blood pressure, glucose tolerance, and body composition in free-living
overweight women.
Can J Physiol Pharmacol. 2002 Nov;80(11):1095-105.
PMID: 12489929 [PubMed - indexed for MEDLINE]
<http://article.pubs.nrc-cnrc.gc.ca/ppv/RPViewDoc?issn=0008-4212&volume=80&issue=11&startPage=1095>
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12489929&dopt=Abstract>

Meckling et al found out that carbohydrate restriction (from 232 g) to about
70 g or less with concomitant energy restriction, without changes in protein or
fat consumption, promotes weight loss, and improvements in body composition,
blood pressure, and blood lipids without compromising glucose tolerance in
moderately overweight women.

Abstract:

"The purpose of the current study was to examine the effects of a
very low-carbohydrate diet on weight loss and biochemical parameters
in overweight women. Twenty women completed an 8-week trial that
reduced their daily carbohydrate intake from 232 to 71 g (p < 0.05)
and reduced energy by 2,644 kJ/day (8,384 to 5,740 kJ, p < 0.001).
The average weight loss was 5.0 kg (p < 0.0001), with a net decrease
in body mass index of 1.82 kg/m2, a loss of 3.4% body fat (4 kg, p <
0.0001), and a loss of 1.0 kg lean mass (p < 0.05). There were no
significant changes in fasting blood glucose, fasting serum insulin,
oral glucose tolerance, free or total insulin-like growth factor-1,
or total IGFBP-3. Systolicblood pressure decreased by an average of
9.0 mmHg (1 mmHg = 133.322 Pa) (p < 0.01) and diastolic blood
pressure decreased by 7 mmHg (p < 0.05). Total cholesterol decreased
1.2 mM (p < 0.001), all of which was accounted for by a decrease in
low-density lipoprotein cholesterol (p < 0.001) with no change in
high-density lipoprotein cholesterol (baseline, 1.17 mM; week 8,
1.22 mM). Total triacylglycerol decreased 0.6 mM (p < 0.01), and the
ratio of triacylglycerol/HDL also significantly decreased (baseline,
1.40; week 8, 0.87; p < 0.001). Serum beta-hydroxybutyrate
concentrations rose significantly by week 2 and declined thereafter
but remained significantly higher than baseline values for the
duration of the intervention.

Uh-oh... *hyperketonemia*

Thank you for providing a reference showing that hyperketonemia does indeed persist.

--
Dr. Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
http://www.heartmdphd.com/

Tue, 21 Oct 2003 21:19:32 -0400 in article <[email hidden]>

Dr. Andrew B. Chung said:

Matti Narkia said:

In their 8-week trial

Meckling KA, Gauthier M, Grubb R, Sanford J.
Effects of a hypocaloric, low-carbohydrate diet on weight loss, blood lipids,
blood pressure, glucose tolerance, and body composition in free-living
overweight women.
Can J Physiol Pharmacol. 2002 Nov;80(11):1095-105.
PMID: 12489929 [PubMed - indexed for MEDLINE]
<http://article.pubs.nrc-cnrc.gc.ca/ppv/RPViewDoc?issn=0008-4212&volume=80&issue=11&startPage=1095>
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12489929&dopt=Abstract>

Meckling et al found out that carbohydrate restriction (from 232 g) to about
70 g or less with concomitant energy restriction, without changes in protein or
fat consumption, promotes weight loss, and improvements in body composition,
blood pressure, and blood lipids without compromising glucose tolerance in
moderately overweight women.

Abstract:

"The purpose of the current study was to examine the effects of a
very low-carbohydrate diet on weight loss and biochemical parameters
in overweight women. Twenty women completed an 8-week trial that
reduced their daily carbohydrate intake from 232 to 71 g (p < 0.05)
and reduced energy by 2,644 kJ/day (8,384 to 5,740 kJ, p < 0.001).
The average weight loss was 5.0 kg (p < 0.0001), with a net decrease
in body mass index of 1.82 kg/m2, a loss of 3.4% body fat (4 kg, p <
0.0001), and a loss of 1.0 kg lean mass (p < 0.05). There were no
significant changes in fasting blood glucose, fasting serum insulin,
oral glucose tolerance, free or total insulin-like growth factor-1,
or total IGFBP-3. Systolicblood pressure decreased by an average of
9.0 mmHg (1 mmHg = 133.322 Pa) (p < 0.01) and diastolic blood
pressure decreased by 7 mmHg (p < 0.05). Total cholesterol decreased
1.2 mM (p < 0.001), all of which was accounted for by a decrease in
low-density lipoprotein cholesterol (p < 0.001) with no change in
high-density lipoprotein cholesterol (baseline, 1.17 mM; week 8,
1.22 mM). Total triacylglycerol decreased 0.6 mM (p < 0.01), and the
ratio of triacylglycerol/HDL also significantly decreased (baseline,
1.40; week 8, 0.87; p < 0.001). Serum beta-hydroxybutyrate
concentrations rose significantly by week 2 and declined thereafter
but remained significantly higher than baseline values for the
duration of the intervention.

Uh-oh... *hyperketonemia*

Thank you for providing a reference showing that hyperketonemia does indeed persist.

You never learn do you? This was only a 2 month study of a special version LC
diet (only change was reduction of carbs). As Foster et al pointed out, even in
Atkins' version of LC diet the level of ketones in urine rose significantly
during first 3 months, after which there was no significant difference in
urinary ketones between LC and control groups. So once again: according to
Foster et al., if you follow the instructions, you don't get problem with
excessive ketosis.

--
Matti Narkia

Matti Narkia <[email hidden]> wrote in message news:<[email hidden]>...

Quoted message said:

Tue, 21 Oct 2003 21:19:32 -0400 in article <[email hidden]>

Dr. Andrew B. Chung said:

Matti Narkia said:

In their 8-week trial

Meckling KA, Gauthier M, Grubb R, Sanford J.
Effects of a hypocaloric, low-carbohydrate diet on weight loss, blood lipids,
blood pressure, glucose tolerance, and body composition in free-living
overweight women.
Can J Physiol Pharmacol. 2002 Nov;80(11):1095-105.
PMID: 12489929 [PubMed - indexed for MEDLINE]
<http://article.pubs.nrc-cnrc.gc.ca/ppv/RPViewDoc?issn=0008-4212&volume=80&issue=11&startPage=1095>
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12489929&dopt=Abstract>

Meckling et al found out that carbohydrate restriction (from 232 g) to about
70 g or less with concomitant energy restriction, without changes in protein or
fat consumption, promotes weight loss, and improvements in body composition,
blood pressure, and blood lipids without compromising glucose tolerance in
moderately overweight women.

Abstract:

"The purpose of the current study was to examine the effects of a
very low-carbohydrate diet on weight loss and biochemical parameters
in overweight women. Twenty women completed an 8-week trial that
reduced their daily carbohydrate intake from 232 to 71 g (p < 0.05)
and reduced energy by 2,644 kJ/day (8,384 to 5,740 kJ, p < 0.001).
The average weight loss was 5.0 kg (p < 0.0001), with a net decrease
in body mass index of 1.82 kg/m2, a loss of 3.4% body fat (4 kg, p <
0.0001), and a loss of 1.0 kg lean mass (p < 0.05). There were no
significant changes in fasting blood glucose, fasting serum insulin,
oral glucose tolerance, free or total insulin-like growth factor-1,
or total IGFBP-3. Systolicblood pressure decreased by an average of
9.0 mmHg (1 mmHg = 133.322 Pa) (p < 0.01) and diastolic blood
pressure decreased by 7 mmHg (p < 0.05). Total cholesterol decreased
1.2 mM (p < 0.001), all of which was accounted for by a decrease in
low-density lipoprotein cholesterol (p < 0.001) with no change in
high-density lipoprotein cholesterol (baseline, 1.17 mM; week 8,
1.22 mM). Total triacylglycerol decreased 0.6 mM (p < 0.01), and the
ratio of triacylglycerol/HDL also significantly decreased (baseline,
1.40; week 8, 0.87; p < 0.001). Serum beta-hydroxybutyrate
concentrations rose significantly by week 2 and declined thereafter
but remained significantly higher than baseline values for the
duration of the intervention.

Uh-oh... *hyperketonemia*

Thank you for providing a reference showing that hyperketonemia does indeed persist.

You never learn do you? This was only a 2 month study of a special version LC
diet (only change was reduction of carbs).

Sounds like even a milder version compared to Atkins...

and yet ketones "remained significantly higher than baseline values for the
duration of the intervention."

So why are you still skirting the concerns about hyperketonemia?

--
Dr. Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
http://www.heartmdphd.com

22 Oct 2003 13:31:34 -0700 in article
<[email hidden]> [email hidden]

(Dr. Andrew B. Chung said:

Matti Narkia <[email hidden]> wrote in message news:<[email hidden]>...

Quoted message said:

Tue, 21 Oct 2003 21:19:32 -0400 in article <[email hidden]>

Dr. Andrew B. Chung said:

Matti Narkia wrote:

> In their 8-week trial
>
> Meckling KA, Gauthier M, Grubb R, Sanford J.
> Effects of a hypocaloric, low-carbohydrate diet on weight loss, blood lipids,
> blood pressure, glucose tolerance, and body composition in free-living
> overweight women.
> Can J Physiol Pharmacol. 2002 Nov;80(11):1095-105.
> PMID: 12489929 [PubMed - indexed for MEDLINE]
> <http://article.pubs.nrc-cnrc.gc.ca/ppv/RPViewDoc?issn=0008-4212&volume=80&issue=11&startPage=1095>
> <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12489929&dopt=Abstract>
>
> Meckling et al found out that carbohydrate restriction (from 232 g) to about
> 70 g or less with concomitant energy restriction, without changes in protein or
> fat consumption, promotes weight loss, and improvements in body composition,
> blood pressure, and blood lipids without compromising glucose tolerance in
> moderately overweight women.
>
> Abstract:
>
> "The purpose of the current study was to examine the effects of a
> very low-carbohydrate diet on weight loss and biochemical parameters
> in overweight women. Twenty women completed an 8-week trial that
> reduced their daily carbohydrate intake from 232 to 71 g (p < 0.05)
> and reduced energy by 2,644 kJ/day (8,384 to 5,740 kJ, p < 0.001).
> The average weight loss was 5.0 kg (p < 0.0001), with a net decrease
> in body mass index of 1.82 kg/m2, a loss of 3.4% body fat (4 kg, p <
> 0.0001), and a loss of 1.0 kg lean mass (p < 0.05). There were no
> significant changes in fasting blood glucose, fasting serum insulin,
> oral glucose tolerance, free or total insulin-like growth factor-1,
> or total IGFBP-3. Systolicblood pressure decreased by an average of
> 9.0 mmHg (1 mmHg = 133.322 Pa) (p < 0.01) and diastolic blood
> pressure decreased by 7 mmHg (p < 0.05). Total cholesterol decreased
> 1.2 mM (p < 0.001), all of which was accounted for by a decrease in
> low-density lipoprotein cholesterol (p < 0.001) with no change in
> high-density lipoprotein cholesterol (baseline, 1.17 mM; week 8,
> 1.22 mM). Total triacylglycerol decreased 0.6 mM (p < 0.01), and the
> ratio of triacylglycerol/HDL also significantly decreased (baseline,
> 1.40; week 8, 0.87; p < 0.001). Serum beta-hydroxybutyrate
> concentrations rose significantly by week 2 and declined thereafter
> but remained significantly higher than baseline values for the
> duration of the intervention.

Uh-oh... *hyperketonemia*

Thank you for providing a reference showing that hyperketonemia does indeed persist.

You never learn do you? This was only a 2 month study of a special version LC
diet (only change was reduction of carbs).

Sounds like even a milder version compared to Atkins...

Milder or not, no adjustments were made in percentages of energy
obtained from the three macronutrient groups, as is done in Atkins' diet
and which in Atkins' diet results to the disappearance of the difference
in ketosis level between Atkin's diet and the conventional weight loss
diet after three months. Please read Foster et al once again.

Quoted message said:

and yet ketones "remained significantly higher than baseline values for the
duration of the intervention."

See above, no adjustments were made during this short, two months study.

Quoted message said:

So why are you still skirting the concerns about hyperketonemia?

Because it's not relevant long term, i.e. after three months in Atkins'
diet, read Foster et al. And no one has shown that even during first
three months the ketosis is so excessive that there would be a reason
for concern; can you show that? Studies have been _very_ quiet about
hyperketonemia, have you thought that the reason for that could be that
there is no need for concern?

--
Matti Narkia

On Wed, 22 Oct 2003 20:56:53 GMT, Matti Narkia <[email hidden]>

Quoted message said:

Studies have been _very_ quiet about
hyperketonemia, have you thought that the reason for that could be that
there is no need for concern?

Prior to 9/11, the US was very_quiet about Al Queda too. Have you
thought that the reason for that could be that there was no need for
concern?

http://antwrp.gsfc.nasa.gov/apod/ap031018.html
Lift well, Eat less, Walk fast, Live long.

Matti Narkia said:

22 Oct 2003 13:31:34 -0700 in article
<[email hidden]> [email hidden]

(Dr. Andrew B. Chung said:

Matti Narkia <[email hidden]> wrote in message news:<[email hidden]>...

Quoted message said:

Tue, 21 Oct 2003 21:19:32 -0400 in article <[email hidden]>
"Dr. Andrew B. Chung, MD/PhD" <[email hidden]> wrote:

>Matti Narkia wrote:
>
>> In their 8-week trial
>>
>> Meckling KA, Gauthier M, Grubb R, Sanford J.
>> Effects of a hypocaloric, low-carbohydrate diet on weight loss, blood lipids,
>> blood pressure, glucose tolerance, and body composition in free-living
>> overweight women.
>> Can J Physiol Pharmacol. 2002 Nov;80(11):1095-105.
>> PMID: 12489929 [PubMed - indexed for MEDLINE]
>> <http://article.pubs.nrc-cnrc.gc.ca/ppv/RPViewDoc?issn=0008-4212&volume=80&issue=11&startPage=1095>
>> <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12489929&dopt=Abstract>
>>
>> Meckling et al found out that carbohydrate restriction (from 232 g) to about
>> 70 g or less with concomitant energy restriction, without changes in protein or
>> fat consumption, promotes weight loss, and improvements in body composition,
>> blood pressure, and blood lipids without compromising glucose tolerance in
>> moderately overweight women.
>>
>> Abstract:
>>
>> "The purpose of the current study was to examine the effects of a
>> very low-carbohydrate diet on weight loss and biochemical parameters
>> in overweight women. Twenty women completed an 8-week trial that
>> reduced their daily carbohydrate intake from 232 to 71 g (p < 0.05)
>> and reduced energy by 2,644 kJ/day (8,384 to 5,740 kJ, p < 0.001).
>> The average weight loss was 5.0 kg (p < 0.0001), with a net decrease
>> in body mass index of 1.82 kg/m2, a loss of 3.4% body fat (4 kg, p <
>> 0.0001), and a loss of 1.0 kg lean mass (p < 0.05). There were no
>> significant changes in fasting blood glucose, fasting serum insulin,
>> oral glucose tolerance, free or total insulin-like growth factor-1,
>> or total IGFBP-3. Systolicblood pressure decreased by an average of
>> 9.0 mmHg (1 mmHg = 133.322 Pa) (p < 0.01) and diastolic blood
>> pressure decreased by 7 mmHg (p < 0.05). Total cholesterol decreased
>> 1.2 mM (p < 0.001), all of which was accounted for by a decrease in
>> low-density lipoprotein cholesterol (p < 0.001) with no change in
>> high-density lipoprotein cholesterol (baseline, 1.17 mM; week 8,
>> 1.22 mM). Total triacylglycerol decreased 0.6 mM (p < 0.01), and the
>> ratio of triacylglycerol/HDL also significantly decreased (baseline,
>> 1.40; week 8, 0.87; p < 0.001). Serum beta-hydroxybutyrate
>> concentrations rose significantly by week 2 and declined thereafter
>> but remained significantly higher than baseline values for the
>> duration of the intervention.
>
>Uh-oh... *hyperketonemia*
>
>Thank you for providing a reference showing that hyperketonemia does indeed persist.

You never learn do you? This was only a 2 month study of a special version LC
diet (only change was reduction of carbs).

Sounds like even a milder version compared to Atkins...

Milder or not, no adjustments were made in percentages of energy
obtained from the three macronutrient groups, as is done in Atkins' diet
and which in Atkins' diet results to the disappearance of the difference
in ketosis level between Atkin's diet and the conventional weight loss
diet after three months. Please read Foster et al once again.

Quoted message said:

and yet ketones "remained significantly higher than baseline values for the
duration of the intervention."

See above, no adjustments were made during this short, two months study.

Quoted message said:

So why are you still skirting the concerns about hyperketonemia?

Because it's not relevant long term

Still seems like it is.

--
Dr. Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
http://www.heartmdphd.com/