I usually use gearing that handles the terrain I ride on and is suitable for my condition.
I was using a 16-27 last year after an injury. I am up to a 14-25 now. I don't really care to ride over 30mph so the 14 is enough. I can handle a mile or so of 15% grade in the 25 (21 if I feel good).
I have 3 rear wheels and 2 bicycles I try to keep my gearing the same on all the wheels. But the 53/39 on one bike and the 50/34 makes the gearing different. If I go out to ride big hills I expect I will put the 27 back on all the wheels I have.
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I don't know what muscle memory has to do with gearing. A 27 just makes the hills look a bit less steep than a 25 does.
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Oklahoma has hills. Talimena drive has some nice 13% grades. After 50 miles of it a 27 looks pretty good. Northeastern Oklahoma has some nice hills. Not long but if you do them long enough a 27 feels good going home.
And don't forget a 27 is nice when you have 30-50 miles into a head wind at the end of a ride.
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In any case put suitable gears on the wheels you will usually use and if you need to change wheels it is easy enough to swap cassettes. I usually just finger tighten the lock ring - makes changing cogs easy.