We have the short-acting reversible MAO-A inhibitors 'moclebemide'. We also have the natural short-
acting reversible MAO-A inhibitors 'harmala alkaloids' that are present in plants like Syrian Rue
and Passion Flower. I have never though seen a pharmaceutical grade anti-depressant medication based
on the harmala alkaloids. It's easy to extract, it's got appealing features (no need for a very
strict diet), so how come the pharmaceutical companies aren't interested in conducting clinical
trials and manifacturing medications based on the harmala alkaloids? Any thoughts?
General fitness, health and nutrition · Public discussion
Harmala alkaloids as anti-depressants
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- General fitness, health and nutrition
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- 29 December 2003
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- 29 December 2003
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- Francis Begbie
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Interest in MAO inhibitors in depression isn't what it was. SSRIs have taken the front. I think the
problem with the alkaloids you speak of would be there unselectivity. I bet they hit up a range of
adrenergic and histaminergic receptors, and I wouldn't be surprised if they hit up some 5-HT
receptors as well.[email hidden] (Francis Begbie) wrote in
:"]news:[email hidden]:Quoted message said:
We have the short-acting reversible MAO-A inhibitors 'moclebemide'. We also have the natural short-
acting reversible MAO-A inhibitors 'harmala alkaloids' that are present in plants like Syrian Rue
and Passion Flower. I have never though seen a pharmaceutical grade anti-depressant medication
based on the harmala alkaloids. It's easy to extract, it's got appealing features (no need for a
very strict diet), so how come the pharmaceutical companies aren't interested in conducting
clinical trials and manifacturing medications based on the harmala alkaloids? Any thoughts?
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