Taurine may have cardioprotective effects including inhibition of
atherosclerosis as suggested by the following references:
1: Matsushima Y, Sekine T, Kondo Y, Sakurai T, Kameo K, Tachibana M, Murakami S. Effects of
taurine on serum cholesterol levels and development of atherosclerosis in spontaneously
hyperlipidaemic mice. Clin Exp Pharmacol Physiol. 2003 Apr;30(4):295-9. <URL:http://www.ncbi.n-
lm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12680850&dopt=Abstract
2: Sethupathy S, Elanchezhiyan C, Vasudevan K, Rajagopal G. Antiatherogenic effect of taurine in
high fat diet fed rats. Indian J Exp Biol. 2002 Oct;40(10):1169-72. <URL:http://www.ncbi.nlm.n-
ih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12693699&dopt=Abstract>
3: Balkan J, Kanbagli O, Hatipoglu A, Kucuk M, Cevikbas U, Aykac-Toker G, Uysal M. Improving
effect of dietary taurine supplementation on the oxidative stress and lipid levels in the
plasma, liver and aorta of rabbits fed on a high-cholesterol diet. Biosci Biotechnol Biochem.
2002 Aug;66(8):1755-8. <URLhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMe-
d&list_uids=12353642&dopt=Abstract>]
4: Murakami S, Kondo Y, Sakurai T, Kitajima H, Nagate T. Taurine suppresses development of
atherosclerosis in Watanabe heritable hyperlipidemic (WHHL) rabbits. Atherosclerosis. 2002 Jul;163(1):79-
87. <URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=120481-
24&dopt=Abstract>
5: Kondo Y, Toda Y, Kitajima H, Oda H, Nagate T, Kameo K, Murakami S. Taurine inhibits development
of atherosclerotic lesions in apolipoprotein E-deficient mice. Clin Exp Pharmacol Physiol. 2001
Oct;28(10):809-15. <URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&l-
ist_uids=11553020&dopt=Abstract>
6: Nonaka H, Tsujino T, Watari Y, Emoto N, Yokoyama M. Taurine prevents the decrease in expression
and secretion of extracellular superoxide dismutase induced by homocysteine: amelioration of
homocysteine-induced endoplasmic reticulum stress by taurine. Circulation. 2001 Sep 4;104(10):1165-
70. <URL:http://circ.ahajournals.org/cgi/content/full/104/10/1165>
7: Murakami S, Kondo Y, Nagate T. Effects of long-term treatment with taurine in mice fed a high-
fat diet: improvement in cholesterol metabolism and vascular lipid accumulation by taurine. Adv
Exp Med Biol. 2000;483:177-86. <URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve-
&db=PubMed&list_uids=11787596&dopt=Abstract>
8: Kondo Y, Murakami S, Oda H, Nagate T. Taurine reduces atherosclerotic lesion development in
apolipoprotein E-deficient mice. Adv Exp Med Biol. 2000;483:193-202. <URL:http://www.ncbi.nlm.-
nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11787598&dopt=Abstract>
9: Murakami S, Kondo Y, Tomisawa K, Nagate T. Prevention of atherosclerotic lesion development in
mice by taurine. Drugs Exp Clin Res. 1999;25(5):227-34. <URL:http://www.ncbi.nlm.nih.gov/entre-
z/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10568211&dopt=Abstract>
10: Murakami S, Kondo-Ohta Y, Tomisawa K. Improvement in cholesterol metabolism in mice given
chronic treatment of taurine and fed a high-fat diet. Life Sci. 1999;64(1):83-91. <URL:http://-
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10027745&dopt=Abstract>
11: Torkunov PA, Sapronov NS. [Cardioprotective effect of taurine] Eksp Klin Farmakol. 1997 Sep-Oct;60(5):72-
7. Review. Russian. <URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&-
list_uids=9483412&dopt=Abstract>
12: Li P, Kang Y, [censored] GX. Prophylactic effects of taurine and diltiazem, alone or combined, on
reperfusion arrhythmias in rats. Zhongguo Yao Li Xue Bao. 1996 Mar;17(2):122-4. <URL:http://ww-
w.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9772659&dopt=Abstract>
13: Raschke P, Massoudy P, Becker BF. Taurine protects the heart from neutrophil-induced
reperfusion injury. Free Radic Biol Med. 1995 Oct;19(4):461-71. <URL:http://www.ncbi.nlm.nih.g-
ov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7590395&dopt=Abstract>
14: Milei J, Ferreira R, Llesuy S, Forcada P, Covarrubias J, Boveris A. Reduction of reperfusion
injury with preoperative rapid intravenous infusion of taurine during myocardial
revascularization. Am Heart J. 1992 Feb;123(2):339-45. <URL:http://www.ncbi.nlm.nih.gov/entrez-
/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1736568&dopt=Abstract>
15: Azuma J, Sawamura A, Awata N. Usefulness of taurine in chronic congestive heart failure and its
prospective application. Jpn Circ J. 1992 Jan;56(1):95-9. <URL:http://www.ncbi.nlm.nih.gov/ent-
rez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1538580&dopt=Abstract>
16: Pukhova TM, Zhuchkova NI. [The effect of taurine on the density of adrenergic nerve endings and
the recovery of cardiac function after ischemia] Biull Eksp Biol Med. 1991 Mar;111(3):241-4.
Russian. <URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2-
054491&dopt=Abstract>
17: Petty MA, Kintz J, DiFrancesco GF. The effects of taurine on atherosclerosis development in cholesterol-
fed rabbits. Eur J Pharmacol. 1990 May 3;180(1):119-27. <URL:http://www.ncbi.nlm.nih.gov/entre-
z/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2364997&dopt=Abstract>
18: Goodman HO, Shihabi ZK. Supplemental taurine in diabetic rats: effects on plasma glucose and
triglycerides. Biochem Med Metab Biol. 1990 Feb;43(1):1-9. <URL:http://www.ncbi.nlm.nih.gov/en-
trez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2310608&dopt=Abstract>
19: Chanh PH, Chahine R, Pham HC, Dossou-Gbete V, Navarro-Delmasure C. Taurine and icosanoids in
the heart. Prostaglandins Leukot Med. 1987 Aug;28(3):243-54. <URL:http://www.ncbi.nlm.nih.gov/-
entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3310012&dopt=Abstract>
20: Yamauchi-Takihara K, Azuma J, Kishimoto S. Taurine protection against experimental arterial
calcinosis in mice. Biochem Biophys Res Commun. 1986 Oct 30;140(2):679-83. <URL:http://www.ncb-
i.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3022727&dopt=Abstract>
21: Azuma J, Sawamura A, Awata N, Ohta H, Hamaguchi T, Harada H, Takihara K, Hasegawa H, Yamagami
T, Ishiyama T, et al. Therapeutic effect of taurine in congestive heart failure: a double-blind
crossover trial. Clin Cardiol. 1985 May;8(5):276-82. <URL:http://www.ncbi.nlm.nih.gov/entrez/q-
uery.fcgi?cmd=Retrieve&db=PubMed&list_uids=3888464&dopt=Abstract>
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Matti Narkia